Anti-bacterium antivirus guanidine salt star-shaped polymer, preparation method and applications thereof

A star polymer, anti-virus technology, applied in the field of guanidinium salt star polymer and its preparation, antibacterial, antiviral guanidinium salt star polymer and its preparation, can solve the problem of antibacterial effect is not durable, to eliminate Potential hazards, safe and harmless to human health, high-efficiency broad-spectrum sterilization effect

Active Publication Date: 2014-01-08
NORTH CHINA ELECTRIC POWER UNIV (BAODING)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is to overcome the defects of the prior art and provide an antibacterial and antiviral guanidinium salt star polymer. The structure and molecular weight of the polymer are regulated, which effectively avoids the pollution of other products caused by the loss of the antibacterial agent and the problems that the antibacterial effect is not durable; at the same time, the present invention also has a significant antibacterial effect that other guanidinium salt polymer antibacterial materials do not have. The ability of viruses such as adenotype and influenza

Method used

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  • Anti-bacterium antivirus guanidine salt star-shaped polymer, preparation method and applications thereof
  • Anti-bacterium antivirus guanidine salt star-shaped polymer, preparation method and applications thereof
  • Anti-bacterium antivirus guanidine salt star-shaped polymer, preparation method and applications thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0038] Example 1 Preparation of functionalized polyhexamethyleneguanidine hydrochloride

[0039] Take by weighing the polyhexamethylene guanidine hydrochloride 40g that molecular weight is 600 and be dissolved in 60g deionized water and be made into the guanidine solution that mass fraction is 40%; Nitrogen gas, 9.5g GMA is slowly added dropwise in this guanidine solution, under nitrogen gas Stir the reaction at room temperature under protection for 24 hours until the oil phase disappears completely, which is obtained.

Embodiment 2

[0040] Example 2 Preparation of functionalized polyhexamethyleneguanidine hydrochloride

[0041] Take by weighing the polyhexamethyleneguanidine hydrochloride 30g that molecular weight is 1000 and be dissolved in 70g deionized water and be made into the guanidine solution that mass fraction is 30%; Nitrogen gas, 4.5g GMA is slowly added dropwise in this guanidine solution, under nitrogen gas Stir the reaction at room temperature under protection for 20 hours until the oil phase disappears completely, which is obtained.

Embodiment 3

[0042] Example 3 Preparation of functionalized polyhexamethyleneguanidine hydrochloride

[0043] Take by weighing the polyhexamethyleneguanidine hydrochloride 30g that molecular weight is 1200 and be dissolved in 70g deionized water and be made into the guanidine solution that mass fraction is 30%; Nitrogen gas, 4.0g GMA is slowly added dropwise in this guanidine solution, under nitrogen gas Stir the reaction at room temperature under protection for 18 hours, until the oil phase disappears completely, which is obtained.

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Abstract

The invention discloses an anti-bacterium antivirus guanidine salt star-shaped polymer, a preparation method and applications thereof, and the arm number, structure and molecular weight of the star-shaped polymer are controllable. The polymer is prepared by the following steps: adopting a core-first method, taking brominated beta-cyclodextrin as an initiator, guanidine salt oligomer containing carbon-carbon double bonds as the functional monomers, and then carrying out atom transfer radical polymerization so as to obtain the target product, wherein the structure and molecular weight of the polymer can be modulated according to the application needs. The polymer and the preparation method thereof improve the molecular weight of the polymer, achieve chain amplification effect, increase the density of effective functional groups having an anti-bacterium effect, effectively solve the problems of contamination on other products caused by leakage of anti-bacterium agents and nondurable anti-bacterium effect, and eliminate the potential dangers caused by leaked anti-bacterium agents on human health. Furthermore, the polymer has a prominent function, which other guanidine salt polymers do not have, of killing wild type viruses and bacteria such as gland virus, influenza virus, and the like.

Description

technical field [0001] The invention relates to a guanidinium salt star polymer and its preparation method and application, in particular to an antibacterial and antiviral guanidinium salt star polymer and its preparation method and application, belonging to the technical field of antiviral and bactericide. Background technique [0002] At present, environmental pollution and sustainable development have become the topics of concern to all countries. Environmental deterioration and the destruction of ecological balance have become one of the serious threats facing human society. The pollution and deterioration of the environment has broken the ecological balance of microorganisms and bacteria around us, and created conditions for the reproduction and survival of various germs and bacteria. Various infectious diseases and diseases caused by harmful germs have seriously endangered human health and even led to death. . Reports in this regard are often seen in newspapers and pe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/56C08F220/36C08B37/16C08F251/00A01N47/44A01P1/00
Inventor 肖惠宁潘远凤
Owner NORTH CHINA ELECTRIC POWER UNIV (BAODING)
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