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Blood lipid reducing composition containing sea buckthorn oil and preparation method of composition

A technology of sea buckthorn oil and composition, applied in the field of traditional Chinese medicine, can solve the problems of liver loss, metabolic disorder in the body, increase the economic burden of patients, etc., and achieve the effects of good curative effect, pure aroma and controllable quality.

Inactive Publication Date: 2014-01-15
TIANJIN TIANSHI BIOLOGICAL DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of drug has a good effect of lowering blood lipids, but long-term use will cause muscle toxicity such as myalgia, muscle inflammation, and even rhabdomyolysis, as well as side effects such as metabolic disorders in the body, gastrointestinal adverse reactions, and liver damage.
At the same time, the price of statins is high, and long-term use will correspondingly increase the economic burden of patients

Method used

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  • Blood lipid reducing composition containing sea buckthorn oil and preparation method of composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] 30MPa static extraction for 10min first, then dynamic extraction, the inlet pressure is 30MPa, the outlet pressure is 5kPa lower than the inlet pressure; the temperature is 15°C, the time is 0.5h, and the volume of CO2 is 20kg / h.

[0048] In the extraction process, the following methods are combined: periodic pressure fluctuations and periodic flow fluctuations; the pressure fluctuation difference of the periodic pressure fluctuations is 5-10Mpa, and the flow velocity fluctuation difference of the periodic flow fluctuations is 1.0-3.0 m / s .

[0049] The oil yield can reach 10.88%.

[0050] Weigh 8% seabuckthorn oil by weight; 36% eicosapentaenoic acid and docosahexaenoic acid; 56% garlic oil, and add auxiliary materials to prepare the traditional Chinese medicine composition of the present invention.

Embodiment 2

[0052] 40MPa static extraction for 10min first, then dynamic extraction, the inlet pressure is 40MPa, the outlet pressure is 10kPa lower than the inlet pressure; the temperature is 40°C, the time is 1h, and the volume of CO2 is 40kg / h.

[0053] The following methods are used alone or in combination during the extraction process: periodic pressure fluctuations, periodic flow fluctuations; the pressure fluctuation difference of the periodic pressure fluctuations is 5-10Mpa, and the flow velocity fluctuation difference of the periodic flow fluctuations is 1.0-3.0 meters / Second.

[0054] The oil yield can reach 11.68%.

[0055] Weigh 36% of seabuckthorn oil by weight; 12% of eicosapentaenoic acid and docosahexaenoic acid; 52% of garlic oil, and add auxiliary materials to prepare the traditional Chinese medicine composition of the present invention.

Embodiment 3

[0057] 30MPa static extraction for 10min first, then dynamic extraction, the inlet pressure is 40MPa, the outlet pressure is 10kPa lower than the inlet pressure; the temperature is 20°C, the time is 0.5h, and the volume of CO2 is 20kg / h.

[0058]The following methods are used alone or in combination during the extraction process: periodic pressure fluctuations, periodic flow fluctuations; the pressure fluctuation difference of the periodic pressure fluctuations is 5-10Mpa, and the flow velocity fluctuation difference of the periodic flow fluctuations is 1.0-3.0 meters / Second.

[0059] The oil yield can reach 11.96%.

[0060] Weigh 12% seabuckthorn oil by weight; 38% eicosapentaenoic acid and docosahexaenoic acid; 50% garlic oil, and add auxiliary materials to prepare the traditional Chinese medicine composition of the present invention.

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Abstract

The invention discloses a blood lipid reducing composition containing sea buckthorn oil. The composition comprises the following components by weight percent: 8-36% of sea buckthorn oil, 12-64% of fatty acid and 6-56% of garlic oil. The invention also discloses a preparation method of sea buckthorn oil in the traditional Chinese medicine composition. The preparation method of the sea buckthorn oil comprises the steps of firstly carrying out static extraction under 30-40MPa for 10 minutes and then carrying out dynamic extraction, wherein the inlet pressure is 30-40MPa, the outlet pressure is 5-10kPa lower than the liquid inlet pressure, the temperature is 15-40 DEG C, the time is 0.5-1 hour and the CO2 volume is 20-40kg / h. The composition makes the best of the efficacy of active pharmaceutical ingredients on cardiovascular diseases, adopts scientific matching, generates synergistic effects, has better curative effects and more controllable quality than traditional preparations and is suitable for industrial production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating cardiovascular diseases and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] With the continuous improvement of people's living standards, changes in diet structure, population aging is becoming more and more obvious, and the incidence of coronary heart disease is increasing day by day. Coronary heart disease is a heart disease caused by narrowing of the lumen caused by coronary atherosclerosis, which causes myocardial blood supply and oxygen supply disturbance, and is known as the "world killer". As far as the whole world is concerned, coronary heart disease has become one of the most serious diseases threatening human health in the past half century, and it is the main cause of death in the United States and some industrialized countries. According to the statistics of the World Health Organization, 24....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8962A61P3/06A61K31/202
Inventor 崔卜东贾林
Owner TIANJIN TIANSHI BIOLOGICAL DEV