Application of CD226 extracellular domain protein in inhibition of tumor cell proliferation

A technology of tumor cell proliferation and CD226, which is applied in the preparation of proteins. The CD226 extracellular segment protein inhibits the proliferation of tumor cells, which can solve the problem of insignificant killing effect and achieve the effect of avoiding side effects.
CN103520705BActive Publication Date: 2015-05-27IMMUNOPHARMACEUTIC INST OF HEFEI RUIDA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
IMMUNOPHARMACEUTIC INST OF HEFEI RUIDA CO LTD
Publication Date
2015-05-27

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Abstract

The invention discloses an effect of inhibiting tumor of CD226 extracellular domain protein. The CD226 extracellular domain protein is a protein consisting of an amino acid sequence shown by SEQ ID NO:1. The protein disclosed by the invention can be combined with CD112 and CD155, can be used for effectively closing binding sites between CD226 and target cells and inhibiting the cellular poison activity of NK cells, can be used as an inhibitor of the NK cells for treating autoimmune diseases on the one hand, and can generate an inhibitory action on proliferation of tumor cells after being combined with CD112 or CD155 molecules on the surfaces of the tumor cells on the other hand. Therefore, the protein can be used for inhibiting the proliferation of tumors in a tumor patient with a low immunologic function. Moreover, because the protein is a human body natural protein, an immunologic reaction of an organism is rarely caused. The invention relates to application of the CD226 extracellular domain protein in preparation of medicaments for inhibiting tumor cell proliferation.
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Description

technical field

[0001] The invention mainly belongs to the field of tumor immunology, and mainly relates to the preparation and application of a protein involved in inhibiting tumor cell growth. Specifically, the present invention relates to the use of CD226 extracellular segment protein to inhibit the proliferation of tumor cells. Background technique

[0002] Natural killer cells (Natural Killer, NK cells) play an extremely important role in innate immunity, mainly including killing tumor cells, killing virus-infected cells, killing intracellular parasites and killing fungi. NK cells mainly function directly in two ways; one is to produce inhibitory effects on target cells by secreting cytokines. The second is to activate NK cells to kill target cells through the recognition between NK cell surface receptors and ligands.

[0003] NK cells function mainly through various activating receptors and inhibitory receptors on the surface of NK cells. CD226 molecule is an activa...

Claims

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