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A kind of cyclic synthetic polypeptide e and its antiviral application

A technology for synthesizing peptides and anti-viruses, applied in anti-viral agents, medical preparations containing active ingredients, peptide sources, etc., can solve the problems that hinder the healthy development of aquaculture production, and the diseases of marine aquaculture animals are difficult to fundamentally control, etc.

Active Publication Date: 2016-05-11
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Shrimp farming occupies an important position in my country's aquaculture industry. In recent years, the disease problems in the shrimp farming process have seriously hindered the healthy development of its farming production. The abuse of antibiotics and the deterioration of the environment have made it difficult for marine animals to suffer from diseases. fundamentally under control

Method used

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  • A kind of cyclic synthetic polypeptide e and its antiviral application
  • A kind of cyclic synthetic polypeptide e and its antiviral application
  • A kind of cyclic synthetic polypeptide e and its antiviral application

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Embodiment Construction

[0023] The present invention is described in further detail below in conjunction with embodiment.

[0024] A chemically synthesized prawn cyclic polypeptide E with obvious antiviral activity, its sequence and source sequence information are as follows:

[0025] (1) Information of SEQ ID No.1

[0026] (a) Sequential features

[0027] * Length: 24 amino acids

[0028] *Type: amino acid

[0029] * Chain type: single chain

[0030] *Topology: ring, disulfide bond formed between two cysteines

[0031] * Spatial structure: has 1) figure 1 Skeleton structure shown: Two cysteines are connected by disulfide bonds to form a ring structure, where the disulfide bonds are shown in darker black, and the C skeleton and other atoms are shown in gray; and 2) figure 2 The spatial structure shown: the polypeptide sequence forms two connected β-sheet structures.

[0032] (b) Molecule type: protein

[0033] Sequence description: SEQIDNo.1

[0034] Ac-Ec(CKFTVKPYIKSFQLYYKGSMWC)P-NH 2

...

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Abstract

The invention relates to a circular synthesized polypeptide E and antibacterial and antivirus application thereof. The circular synthesized polypeptide E has structural characteristics and an amino acid sequence represented by SEQ ID NO:1 in a sequence list; the circular synthesized polypeptide E is derived from the LPS binding domain of Chinese Fenneropenaeus merguiensis anti-lipopolysaccharide factor ALFFc represented by SEQ ID NO:2 in the sequence list; by performing a biological function verification in vitro on the circular synthesized polypeptide E, the circular synthesized polypeptide E is verified to have a very strong inhibition action to the proliferation of viruses.

Description

technical field [0001] The present invention relates to a cyclic synthetic polypeptide E and its antiviral application, in particular to a synthetic cyclic polypeptide derived from the lipopolysaccharide (LPS) binding domain of Penaeus prawn anti-lipopolysaccharide factor ALFFc and its antiviral application. Antiviral application. Background technique [0002] Shrimp farming occupies an important position in my country's aquaculture industry. In recent years, the disease problems in the shrimp farming process have seriously hindered the healthy development of its farming production. The abuse of antibiotics and the deterioration of the environment have made it difficult for marine animals to suffer from diseases. fundamentally under control. [0003] Antimicrobial peptides (proteins) are considered to be important effector molecules for fish, shrimp, shellfish, etc. to defend against infection by exogenous pathogens such as bacteria and viruses, and play an important role in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/435A61K38/17A61P31/20
Inventor 李诗豪李富花郭书悦相建海
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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