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A kind of cyclic synthetic polypeptide h and its application and antibacterial preparation

A synthetic polypeptide and cyclic technology, applied in the field of cyclic polypeptides and their antibacterial applications, can solve the problem that the antiviral mechanism of ALF is not clear.

Active Publication Date: 2020-06-26
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The mechanism of action of ALF antiviral is still unclear

Method used

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  • A kind of cyclic synthetic polypeptide h and its application and antibacterial preparation
  • A kind of cyclic synthetic polypeptide h and its application and antibacterial preparation
  • A kind of cyclic synthetic polypeptide h and its application and antibacterial preparation

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Embodiment Construction

[0021] The present invention is described in further detail below in conjunction with embodiment.

[0022] A chemically synthesized shrimp cyclic polypeptide H with obvious antibacterial activity, its sequence and source sequence information are as follows:

[0023] (1) Information of SEQ ID No.1

[0024] (a) Sequential features

[0025] * Length: 22 amino acids

[0026] *Type: amino acid

[0027] * Chain type: single chain

[0028] *Topology: ring, disulfide bond formed between two cysteines

[0029] *Space structure: Two cysteines are connected by disulfide bonds to form a ring structure with 1) figure 1 The spatial structure shown: the polypeptide sequence forms two connected β-sheet structures.

[0030] (b) Molecule type: protein

[0031] Sequence description: SEQ ID No.1

[0032] Ac-c(CSYSTRPYFIRWQLKFKTKIWC)-NH 2

[0033] Among them, the amino acid in brackets is a ring-forming amino acid, and the lowercase c on the left side outside the brackets indicates that ...

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Abstract

The invention relates to a cyclic synthetic polypeptide H and an antibacterial application thereof. The cyclic synthetic polypeptide H of the invention has an amino acid sequence and structural characteristics as shown by SEQ ID No.1 in a sequence list. The cyclic synthetic polypeptide H is derivated from a LPS combination structural domain of Fenneropenaeus chinensiss lipotropism polysaccharide factor FcALF8 as shown by SEQ ID No.2. By performing the biological function in vitro verification for the cyclic synthetic polypeptide H, the cyclic synthetic polypeptide H has good effect on inhibiting the growth or proliferation of gram-positive bacteria and gram-negative bacteria.

Description

technical field [0001] The present invention relates to a cyclic synthetic polypeptide H and its antibacterial application, specifically a synthetic cyclic polypeptide derived from the lipopolysaccharide (LPS) binding domain of the anti-lipopolysaccharide factor FcALF8 of Penaeus prawn and its antibacterial application application. Background technique [0002] Shrimp farming occupies an important position in my country's aquaculture industry. In recent years, the disease problems in the shrimp farming process have seriously hindered the healthy development of its farming production. The abuse of antibiotics and the deterioration of the environment have made it difficult for marine animals to suffer from diseases. fundamentally under control. [0003] Antimicrobial peptides (proteins) are considered to be important effector molecules for fish, shrimp, shellfish, etc. to defend against infection by exogenous pathogens such as bacteria and viruses, and play an important role i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/435A61K38/17A61P31/04
CPCA61K38/00C07K14/43509Y02A50/30
Inventor 李诗豪李富花吕新嘉相建海
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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