Preparation method and application of surface molecular imprinting solid-phase adsorbent for psychiatric drugs

A technology of surface molecular imprinting and solid-phase adsorption, applied in chemical instruments and methods, other chemical processes, etc., can solve the problems of low binding recognition efficiency, failure to overcome, and template molecule embedding too deep, and improve the imprinting efficiency and adsorption. The effect of desorption rate, change of reaction monomer species, and reduction of entrapment phenomenon

Inactive Publication Date: 2014-02-05
NINGXIA UNIVERSITY
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Problems solved by technology

This can solve the problems that the MIPs imprints prepared by other methods embed the template molecules too deeply, the imprinting efficiency is not high; the mass transfer speed is slow, and the binding recognition efficiency is low.
[0005] So far, there is no way to overcome the above drawbacks

Method used

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  • Preparation method and application of surface molecular imprinting solid-phase adsorbent for psychiatric drugs
  • Preparation method and application of surface molecular imprinting solid-phase adsorbent for psychiatric drugs
  • Preparation method and application of surface molecular imprinting solid-phase adsorbent for psychiatric drugs

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Embodiment 1

[0027] Embodiment 1: A method for preparing a molecularly imprinted solid-phase adsorbent on the surface of psychotropic drugs, which is characterized in that the surface-induced atom transfer radical polymerization method is adopted on the surface of the polymer resin: the method is firstly to chloromethyl on the surface of the styrene resin Chemical preparation of macromolecular initiator: take 5 g of pretreated styrene resin (particle size 03-1.25 mm) into a flask, add 8 g of paraformaldehyde, 15 g of anhydrous zinc chloride, and 30 mL of 80% concentrated sulfuric acid , 60 mL of glacial acetic acid, under the condition of 50-55 ℃ magnetic stirring, pass through self-made hydrogen chloride gas to react for 12 h. After the reaction, wash with a large amount of deionized water until neutral, wash with ethanol and acetone, and dry in vacuum at 50 ℃ 24 h, put it in a desiccator for later use, and then obtain the chloromethylated polystyrene resin; then prepare the barbiturate mo...

Embodiment 2

[0028]Embodiment 2: A method for preparing a molecularly imprinted solid-phase adsorbent on the surface of psychotropic drugs, which is characterized in that the surface-induced atom transfer radical polymerization method is adopted on the surface of the polymer resin: the method is first to chloromethyl on the surface of the styrene resin Chemical preparation of macromolecular initiator: take 10 g of pretreated styrene resin (particle size 03-1.25 mm) into a flask, add 10 g of paraformaldehyde, 20 g of anhydrous zinc chloride, 40 mL of 80% Concentrated sulfuric acid, 80 mL glacial acetic acid, under the condition of 50~55 ℃ magnetic stirring, pass through self-made hydrogen chloride gas to react for 12 h. Vacuum-dried for 24 h, and placed in a desiccator for later use, the chloromethylated polystyrene resin can be obtained. Then, the preparation of benzodiazepine molecularly imprinted solid-phase extraction agent: 5 mL methacrylic acid and 0.6 g benzodiazepine Zhuo was placed...

Embodiment 3

[0029] Example 3: A method for preparing a molecularly imprinted solid-phase adsorbent on the surface of psychotropic drugs, which is characterized in that the surface-induced atom transfer radical polymerization method is adopted on the surface of the polymer resin: the method is firstly to chloromethyl on the surface of the styrene resin Chemical preparation of macromolecular initiator: take 15 g of pretreated styrene resin (particle size 03-1.25 mm) into a flask, add 15 g of paraformaldehyde, 25 g of anhydrous zinc chloride, and 50 mL of 80% concentrated Sulfuric acid, 100 mL glacial acetic acid, under the condition of 50~55 ℃ magnetic stirring, pass through self-made hydrogen chloride gas to react for 12 h. Dry for 24 h and place in a desiccator for later use to obtain chloromethylated polystyrene resin; then prepare diazepam molecularly imprinted solid-phase extraction reagent: put 7 mL of acrylic acid and 0.8 g of diazepam at 250 mL of round bottom flask, add 20 mL of ac...

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Abstract

The invention relates to a molecular imprinting solid-phase extraction adsorbent and a chromatographic separation solid phase, and relates to a preparation method of a surface molecular imprinting solid-phase adsorbent for psychiatric drugs, which has specific recognition performance for the psychiatric drugs. The method comprises the following steps: preparing a macroinitiator on the surface of styrene resin through chloromethylation; initiating the functional monomer polymerization by use of the initiator, eluting a template molecule, washing and testing the adsorption property of the adsorbent. By adopting the technology, the influence of nonspecific adsorption on selectivity can be reduced, the embedding phenomenon of the existing molecular imprinting is greatly reduced, the imprinting efficiency and adsorption / desorption rate can be improved, the variety of the reaction monomer is changed, and the product has the characteristics of multiple functional groups and the like and can be widely applied to solid-phase extraction adsorbents.

Description

technical field [0001] The invention relates to a molecularly imprinted solid-phase extraction adsorbent and a chromatographic separation stationary phase, and relates to a preparation method and application of a molecularly imprinted solid-phase adsorbent on the surface of psychotropic drugs that has specific recognition performance for psychotropic drugs. Background technique [0002] Molecular imprinting technique (MIT) is a new molecular recognition technology developed in recent years. It can specifically identify and adsorb target molecules, and complete the purpose of separating and enriching a specific trace analyte from complex substrates. Therefore, it is often used as a solid phase extraction filler, solid phase microextraction coating or prepared as a sensor to separate and enrich trace analytes in complex samples. It is used in the analysis of source components, which greatly improves the detection efficiency and sensitivity. [0003] Although MIPs have been w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F257/02C08F226/06C08F222/14C08F220/06C08J9/26B01J20/26B01J20/30
Inventor 龚波林
Owner NINGXIA UNIVERSITY
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