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Pharmaceutical composition for treating cognitive disorder and application thereof in preparation of medicine for treating Alzheimer disease

A technology for cognitive dysfunction and Alzheimer's disease, which is applied in the field of pharmaceutical compositions for the treatment of cognitive dysfunction and its preparation, and can solve the problems of difficult control of impurity content, difficulty in effectively maintaining product stability, and difficult industrial To achieve the effect of concise formula, reducing the amount of herbal flavors and medicinal materials used, and saving resources

Active Publication Date: 2014-02-12
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above-mentioned pharmaceutical preparations have different degrees of therapeutic effects on senile dementia patients, it is difficult to industrialize this type of compound, especially in industrialized large-scale production. Maintain product stability and ensure its product quality

Method used

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  • Pharmaceutical composition for treating cognitive disorder and application thereof in preparation of medicine for treating Alzheimer disease
  • Pharmaceutical composition for treating cognitive disorder and application thereof in preparation of medicine for treating Alzheimer disease
  • Pharmaceutical composition for treating cognitive disorder and application thereof in preparation of medicine for treating Alzheimer disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Weigh 5 g of raw materials astragalus, 5 g of baicalin, 5 g of Alisma, 5 g of salvia miltiorrhiza, and 3 g of ginseng, directly pulverize the raw materials, add conventional drug excipients, and press into tablets to obtain tablets. It is used to improve cognitive dysfunction, treat Alzheimer's disease, improve glucose metabolism, and increase the content of monoamine neurotransmitters in the brain.

Embodiment 2

[0027] Weigh 10g of raw materials astragalus, 10g of baicalin, 10g of Alisma, 10g of salvia miltiorrhiza, and 5g of ginseng. After mixing the ingredients, add 5 times the amount of ethanol with a concentration of 95% to extract for 24 hours, concentrate under reduced pressure to obtain extract A, and keep the dregs; S2 : Dry the dregs of the medicine in step S1, add 5 times the amount of water to soak for 1 hour, decoct for 2 hours, decoct twice, combine the two decoctions, concentrate to obtain extract B, and keep the dregs of the medicine; S3: the step of S2 The dregs were dried, added 5 times the amount of ethanol with a concentration of 70% to extract for 24 hours, concentrated under reduced pressure to obtain extract C; S4: crushed extract A, extract B and extract C, and added conventional pharmaceutical excipients according to the conventional process Tablets are obtained by compression. It is used to improve cognitive dysfunction, treat Alzheimer's disease, improve gluc...

Embodiment 3

[0029]Weigh 20g of raw materials astragalus, 15g of baicalin, 15g of Alisma, 15g of salvia miltiorrhiza, and 10g of ginseng. After mixing the various flavors, add 5 times the concentration of 70% ethanol to extract for 20h, concentrate under reduced pressure to obtain extract A, and keep the dregs; S2 : Dry the dregs of S1 step, add 5 times the amount of water to soak for 1 hour, decoct for 1.5 hours, decoct twice, combine the two decoctions, concentrate to obtain extract B, and keep the dregs; S3: S2 The dregs in the step are dried, added 5 times the amount of ethanol with a concentration of 40% to extract for 20 hours, concentrated under reduced pressure to obtain extract C; S4: crush extract A, extract B and extract C, and add conventional drugs according to the conventional process Excipients are compressed to obtain tablets. It is used to improve cognitive dysfunction, treat Alzheimer's disease, improve glucose metabolism, and increase the content of monoamine neurotransm...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine and specifically provides a pharmaceutical composition for treating cognitive disorder. The pharmaceutical composition is composed of astragalus root, scutellaria baicalensis, rhizoma alismatis, salviae miltiorrhizae and ginseng. The invention also discloses a novel usage of the pharmaceutical composition in preparation of medicine for perfecting Alzheimer disease. The pharmaceutical composition provided by the invention can inhibit the expression of APP, A beta-40 and A beta-42 in a brain tissue, greatly improve the learning and memory ability of a quasi dementia mouse caused by scopolamine and reduce the ACHE activity of the brain tissue, so that the pharmaceutical composition provided by the invention has a good anti-dementia effect. In senile dementia treatment, the pharmaceutical composition provided by the invention can greatly improve the sugar metabolism of a dementia rat model and can also increase the contents of noradrenaline, dopamine and serotonin in pallium of a rapid brain aging mouse.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating dementia, in particular to a pharmaceutical composition for treating cognitive dysfunction, its preparation method and application, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] Cognitive dysfunction generally refers to various degrees of cognitive impairment caused by various reasons, and it is a frequently-occurring and common disease in clinical practice. The pathogenesis and mechanism of this disease are not very clear at present, and patients often develop from mild cognitive impairment to dementia. As my country gradually enters an aging society, the prevalence of cognitive dysfunction is increasing year by year. Cognitive dysfunction has become an important disease that affects the health and quality of life of middle-aged and elderly people. The manifestations of cognitive dysfunction include not only memory imp...

Claims

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Application Information

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IPC IPC(8): A61K36/884A61P25/28
Inventor 王永炎
Owner LUNAN PHARMA GROUP CORPORATION
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