Biomaterial three-dimensional forming equipment and its extrusion nozzle

A biomaterial and three-dimensional forming technology, which is applied in the fields of biomanufacturing and biomaterial three-dimensional printing, can solve the problems of small material temperature control range, limited material viscosity adjustment range, and unsatisfactory forming effect, so as to achieve temperature control and precise temperature control Effect
CN103587119BInactive Publication Date: 2015-11-18SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
Publication Date
2015-11-18
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention discloses three-dimensional biological material forming equipment and extrusion nozzles thereof. The three-dimensional biological material forming equipment is characterized by comprising material extrusion drive units and before-extrusion temperature control units, wherein the before-extrusion temperature control units comprise heat conduction sleeves, heating bodies and semiconductor refrigeration systems; the semiconductor refrigeration systems comprise semiconductor refrigeration plates; the heat conduction sleeves are used for fixing syringes filled with biological materials; after the heat conduction sleeves fix syringes, the inner surfaces of the heat conduction sleeves are contacted with container walls of the syringes; the heating bodies are in heat conduction connection with the heat conduction sleeves; the semiconductor refrigeration plates are fixed on the outer surfaces of the heat conduction sleeves, and cold effect surfaces are tightly attached to the heat conduction sleeves; the material extrusion drive units are used for pushing pistons of the syringes fixed in the heat conduction sleeves so as to extrude the biological materials in the syringes. Compared with the prior art, a better forming effect can be obtained.
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Description

technical field

[0001] The invention relates to biomanufacturing technology and three-dimensional printing of biomaterials, in particular to three-dimensional forming equipment of biomaterials and extrusion nozzles thereof. Background technique

[0002] Three-dimensional bioprinting or rapid prototyping of biomaterials is to extrude or spray biomaterials or cells into a special forming environment, and use layer-by-layer manufacturing to manufacture tissue engineering scaffolds or three-dimensional cell structures. In this technology, the nozzle for extrusion or injection of biomaterials is a key component. Biomaterials can generally be configured into solutions or sols. Liquid biomaterial solutions are extruded or sprayed under the action of compressed gas, piston push, screw extrusion, or piezoelectric crystals. Under special circumstances (such as cooling and containing The medium environment of the crosslinking agent, etc.) solidifies or cures.

[0003] The forming env...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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