Biochip for high efficiently separating cells

Abstract

A biochip for high efficiently separating cells is composed of a cover plate layer and a slide glass arranged below the cover plate layer; a micro-channel which is used for high efficiently separating cells is arranged in the cover plate layer, the micro-channel comprises a fluid inlet, a separating area, and fluid outlets, which are orderly communicated; a first separating area, which communicates with the separating area and the fluid inlet, is composed of a plurality of alternatively arranged expanding sections and a symmetric sharp corner structure; a second separating area is composed of three channels, which are the branches of the first separating area, the fluid outlets comprises a middle fluid outlet and two lateral fluid outlets, and the three fluid outlets respectively communicate with the three channels in the second separating area; the fluid inlet and the fluid outlets are through holes which are arranged in the cover plate layer, the separating areas are typhlosoles which are arranged in the cover plate layer, and the bottom part communicates with the surface of the slide glass. The cells with a large size have a large inertia, so the cells can quickly move to the center of the micro-channel and are discharged from the middle fluid outlet, the cells with a small size are arranged along the two sides of the micro-channel and discharged from the two lateral fluid outlets, so that the high efficient separation of cells with different sizes is achieved. The biochip can be widely applied to the fields of bio-medicine and environment supervision.

Description

technical field [0001] The invention relates to a biological chip, in particular to a biological chip for efficient separation of cells. Background technique [0002] In the medical field, blood testing is an important way to evaluate the health status of the human body. The blood cells in the blood are mainly divided into red blood cells, white blood cells and platelets. Red blood cells are generally biconcave discs, which mainly play the role of material transport in the human body. For example, the oxygen inhaled from the lungs and the nutrients absorbed from the digestive tract can only reach the tissues of the body through red blood cells. At the same time, the carbon dioxide produced by tissue metabolism and Other wastes also rely on the red blood cells in the blood to be transported to the lungs, kidneys, etc. for excretion, so as to maintain the normal metabolism of the body. White blood cells are colorless nucleated spherical cells, generally larger than red blood...

AI Technical Summary

Problems solved by technology

Although the traditional cell separation method can separate the target cells from other cells, it has the following disadvantages: 1) It is expensive and expensive, which is not conducive to the promotion and use in primary medical institutions; 2) It requires external power and consumes energy High; 3) bulky, not easy to carry; 4) complex structure, requiring precision equipment; 5) high cost of use and maintenance

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