Moxifloxacin hydrochloride tablet and preparation method thereof

A technology of moxifloxacin hydrochloride and tablet, which is applied in the field of moxifloxacin hydrochloride tablet and its preparation, can solve the problems affecting the disintegration time limit of the tablet, and achieve the advantages of convenient industrialization and clinical use, low price and beautiful appearance Effect

Active Publication Date: 2014-03-26
山东淄博新达制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this invention has improved the hardness of tablet to a certain extent, and as we all

Method used

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  • Moxifloxacin hydrochloride tablet and preparation method thereof
  • Moxifloxacin hydrochloride tablet and preparation method thereof
  • Moxifloxacin hydrochloride tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0029] Example 1

[0030]

[0031] The preparation method of moxifloxacin hydrochloride tablets in this embodiment is as follows:

[0032] 1. Pass moxifloxacin hydrochloride through an 80 mesh sieve and set aside;

[0033] 2. Accurately weigh moxifloxacin hydrochloride, MCC, pregelatinized starch and one-third of the prescription amount of CC-Na according to the prescription amount and mix them through a 120-mesh sieve, and then mix well;

[0034] 3. The concentration of PVP K30 prepared by adding water is 8.0%wt, and the amount of 100 pieces of 28ml binder is passed through a 16-mesh sieve, and dried at 50℃ for 1.5 hours;

[0035] 4. Add the remaining CC-Na and magnesium stearate, mix well, press the tablet after passing the test of the intermediate, and coat it with Opadry film coating powder.

Example Embodiment

[0036] Example 2

[0037] In this example, the moxifloxacin hydrochloride tablets, in terms of weight fraction, have the following raw materials:

[0038]

[0039]

[0040] The preparation method of moxifloxacin hydrochloride tablets in this embodiment is as follows:

[0041] 1. Pass moxifloxacin hydrochloride through an 80 mesh sieve and set aside;

[0042] 2. Accurately weigh moxifloxacin hydrochloride, MCC, pregelatinized starch, and half of the prescription amount of CC-Na according to the prescription amount, mix them with a 200-mesh sieve, and then mix;

[0043] 3. The concentration of PVP K30 prepared by adding water is 6.0%wt, and 100 pieces of 39ml binder are used to pass through a 16-mesh sieve to granulate, and dry at 60°C for 1.0 hour;

[0044] 4. Add the remaining CC-Na, and magnesium stearate, mix well, press the tablet after passing the intermediate test, and then coat it with Opadry film coating powder.

Example Embodiment

[0045] Example 3

[0046] In this example, the moxifloxacin hydrochloride tablets, in terms of weight fraction, consist of the following raw materials:

[0047]

[0048] The preparation method of moxifloxacin hydrochloride tablets in this embodiment is as follows:

[0049] 1. Pass moxifloxacin hydrochloride through an 80 mesh sieve and set aside;

[0050] 2. Accurately weigh moxifloxacin hydrochloride, MCC, pregelatinized starch, and a quarter of the prescription amount of CC-Na according to the prescription amount and mix them through a 100-mesh sieve, and then mix;

[0051] 3. The concentration of PVP K30 prepared by adding water is 10.0%wt, and 100 pieces of 23ml binder are used to pass through a 16-mesh sieve to granulate, and then dried at 40℃ for 2 hours;

[0052] 4. Add the remaining CC-Na and magnesium stearate, mix well, press the tablet after passing the intermediate test, and coat with Opadry film coating powder.

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Abstract

The invention relates to the field of pharmacy technologies and in particular relates to a moxifloxacin hydrochloride tablet and a preparation method thereof. The moxifloxacin hydrochloride tablet is prepared from the following raw materials in parts by weight: 60-64 parts of moxifloxacin hydrochloride, 19-26 parts of filler, 7.0-12.5 parts of disintegrating agent, 0.6-1.6 parts of flow aid, 2.5-3.7 parts of adhesive and 1.4-2.6 parts of opadry film coating powder. The preparation method of the moxifloxacin hydrochloride tablet is simple and feasible. Due to the proportional composition of the components of the moxifloxacin hydrochloride tablet and the process, the problem of disintegrating time limit is solved; due to the adoption of the opadry film coating powder, the moxifloxacin hydrochloride tablet is attractive in appearance and the stability of the tablet is ensured; the moxifloxacin hydrochloride tablet is appropriate in hardness, disintegration property, dissolvability and stability; in addition, the auxiliary material used for the moxifloxacin hydrochloride tablet is low in cost, safe and reliable; industrialization and clinical use are facilitated.

Description

Technical field [0001] The invention relates to the technical field of pharmacy, in particular to a moxifloxacin hydrochloride tablet and a preparation method thereof. Background technique [0002] Moxifloxacin is developed by Bayer, Germany. It is a fourth-generation ultra-wide-spectrum quinolone antibiotic. It has shown resistance to Gram-positive bacteria (Staphylococcus, Streptococcus pneumoniae, Mycobacterium), Gram-negative bacteria, and anorexia in vitro. Aerobic bacteria, acid-fast bacteria and atypical microorganisms (mycoplasma, chlamydia and legionella) have broad-spectrum antibacterial activity. By interfering with Ⅱ and Ⅳ topoisomerases, it can control DNA topology and DNA replication, repair and transcription. It is mainly used to treat adults suffering from respiratory infections, such as acute sinusitis, acute exacerbation of chronic bronchitis, community-acquired pneumonia, and skin and soft tissue infections. [0003] [0004] Moxifloxacin has strong antibacteri...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K31/4709A61P31/04
Inventor 吴照刚贾法强王晴雯李宝东
Owner 山东淄博新达制药有限公司
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