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Application of jaceosidin in preparation of drugs used for preventing or treating pulmonary fibrosis

A technology of palm cyanidin and pulmonary fibrosis, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc.

Active Publication Date: 2014-03-26
安徽格太信控科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Palm cyanidin is a single compound extracted from Artemisia argyi [Tang Shengan, Sun Liang, Zhai Huiyuan, Duan Hongquan, Zhang Yanwen. Research on the chemical constituents of Artemisia argyi. Journal of Tianjin Medical University, 2011, 17(4): 461-463.], Palm cyanidins have anti-inflammatory effects [Clavin M, Gorzalczany S, Macho A, E, Ferraro G, Acevedo C, Martino V.Anti-inflammatory activity of flavonoids from Eupatorium amottianum.J Ethnopharmacol.2007;112(3):585-589.], but brown cyanidin in the preparation of prevention or treatment of pulmonary fibrosis The pharmacological effect of chemical has not been reported

Method used

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  • Application of jaceosidin in preparation of drugs used for preventing or treating pulmonary fibrosis

Examples

Experimental program
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Effect test

preparation example 1

[0010] Preparation Example 1: Preparation of palm cyanidin

[0011] 1kg of dried Artemisia argyi leaves was crushed, heated and refluxed with 6 times the amount of 95% ethanol for 3 times, each time for 6 hours, filtered, combined the filtrate, concentrated under reduced pressure to extract the extract, added an appropriate amount of distilled water to suspend, and dissolved in 10L Extract with ethyl acetate in a separatory funnel, collect the extract and separate it with silica gel column chromatography (silica gel 600g, 300-400 mesh), and use CH2Cl2→CH2Cl2:EtoAc (5:1→2:1)→EtoAc→MeOH in sequence Gradient elution, combined similar components by TLC, and passed through a silica gel column with normal pressure to obtain 460 mg of palmicyanidin.

Embodiment 2

[0012] Embodiment 2 palm cyanidin tablet preparation

[0013] Weigh 20.0g palm cyanidin, 55.0g powdered sugar, 100.0g lactose and 23.0g sodium carboxymethyl starch, mix well and pass through a 100-mesh sieve, add an appropriate amount of 3% PVP K30 Appropriate amount of water solution to make soft material, granulate with 20-mesh sieve, dry at 60°C for 3 hours, granulate with 18-mesh sieve, add 2.0g of magnesium stearate, mix evenly, punch with shallow concave, and adjust the tablet weight to about 200mg.

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Abstract

The invention provides novel pharmaceutical purposes of jaceosidin and specifically relates to application of jaceosidin in prevention or treatment of pulmonary fibrosis, wherein through inhibition of pulmonary epithelial-mesenchymal transition, pulmonary vascular endothelial-mesenchymal transition and propagation of fibroblasts, growth and development of pulmonary fibrosis are inhibited, so prevention or treatment of pulmonary fibrosis is realized. In the above-mentioned application, the dosage range of applied jaceosidin is 20 to 1000 mg, preferably, 20 to 500 mg.

Description

technical field [0001] The invention relates to palm cyanidin inhibiting the occurrence and development of pulmonary fibrosis so as to prevent or treat pulmonary fibrosis; specifically, palm cyanidin inhibits lung epithelial cell-mesenchymal transition and pulmonary vascular endothelial cell-mesenchymal transition, inhibits The abnormal activation of pulmonary fibroblasts can inhibit the occurrence and development of pulmonary fibrosis, so as to prevent or treat pulmonary fibrosis. Background technique: [0002] Idiopathic pulmonary fibrosis (IPF), also known as cryptogenic fibrosing alveolitis (CFA), is a chronic inflammatory interstitial disease. (usual interstitialpneumonia, UIP) is a characteristic pathological change with unknown etiology. The main manifestations are that the appearance of fibroblastic foci leads to the deposition of a large amount of extracellular matrix (ECM), the accumulation of collagen, and the destruction of alveolar structure, which eventually l...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P11/00
Inventor 蒋王林亢泽春
Owner 安徽格太信控科技有限公司
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