A kind of aryltriazole compound containing chlorocyclopropane and its preparation method and application

Abstract

The invention discloses an aryl triazole compound containing chlorinated cyclopropane and a preparation method and application thereof. The structural formula of the aryl triazole compound containing chlorinated cyclopropane is shown in formula I, wherein X represents C=O or CHOH, and R represents a substituent phenyl group; the substituent in the substituent phenyl group is any one of the following groups: halogen, methyl group, methoxyl group, nitro group, trifluoromethyl group, amino group, and acetyl amino group. The preparation method, provided by the invention, adopts cheap raw materials, and takes a simple reaction route; the synthesized compound has both plant growth regulating activity and bactericidal activity, thereby having a wider application range; in application experiments of the aryl triazole compound containing chlorinated cyclopropane, the plant growth regulating activity shows that the synthesized compound manifests excellent plant growth regulating activity; in application experiments of the aryl triazole compound containing chlorinated cyclopropane, the bactericidal activity test result shows that the compound has excellent growth inhibition effect on sclerotinia sclerotiorum, tomato fungus phytophthora, botrytis cinerea, rhizoctonia solani seedbed, blast fungus, asparagus stem blight, fusarium graminearum, pythium germs, and the like.

Description

technical field [0001] The invention relates to an aryl triazole compound containing chlorinated cyclopropane, a preparation method and application thereof. Background technique [0002] Five-membered ring compounds containing heteroatoms such as N and S are chemical structures that have attracted wide attention in the research fields of medicine, pesticides and veterinary drugs. Due to their different fine structures, these compounds often have unique insecticidal, acaricidal, bactericidal, Activities such as herbicide and plant growth regulation can be used as insecticide, acaricide, fungicide, herbicide, plant growth regulator and anthelmintic in agriculture. Many pesticides of this type are currently commercialized and have good biological activity. The inventors have obtained multiple series of active structures in the synthesis and biological activity research of compounds containing 1,3,4-thiadiazole five-membered heterocyclic structures, such as 2-dodecamethylene-5-...

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Problems solved by technology

[0003] The research group’s previous research on the fungicidal activity of 1,3,4-thiadiazole derivatives modified with fifteen-membered rings, twelve-membered rings and six-membered rings showed that the size of the ring has a great influence on the activity of these compounds. The bactericidal activity of the 12-membered ring replaced by the 6-membered ring is improved. At the same time, the bactericidal activity of prothioconazole, cyproconazole and other fungicides containing three-membered ring modifications is better than that of tebuconazole without the three-membered ring. However, triazole compounds have certain plant growth regulating activity and bactericidal activity. The commercial products contain triazole ring in the structure of uniconazole and paclobutrazol, but in practical application, the existing commercial varieties have a certain long residual effect period, Insufficiencies such as low selectivity, looking for efficient and highly active new plant growth regulators are the focus of people's attention

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