Method for preparing chitosan with ultrahigh deacetylation degree

A technology of deacetylation and chitosan, which is applied in the field of marine chemical engineering, can solve the problems of large amount of alkali, pollute the environment, and high economic cost, and achieve the effect of small molecular weight change, reduce the amount of alkali, and mild reaction conditions

Active Publication Date: 2014-04-09
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
View PDF4 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the amount of alkali used in the traditional lye heating method in China is relatively large, which not only has high economic costs but also pollutes the environment. Therefore, it is urgent to find a simple, convenient, efficient and low-cost deacetylation method to meet the requirements of ultra-high deacetylation degree chitosan. Applications in food, medicine and high-performance materials

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing chitosan with ultrahigh deacetylation degree
  • Method for preparing chitosan with ultrahigh deacetylation degree
  • Method for preparing chitosan with ultrahigh deacetylation degree

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] In sequentially numbered measuring cups, weigh a certain amount of chitosan (the degree of deacetylation is 60%-85%) and NaOH solid, add deionized water and stir rapidly with a glass rod to fully dissolve and mix the two. NaOH dissolves completely with a large exotherm. Place the measuring cup in a vertical pressure steam sterilizer, and set the reaction temperature and reaction time. After the reaction, the chitosan in the measuring cup was washed to neutral with deionized water and suction filtered. After suction filtration, the product was dried in an oven at 105°C to constant weight, the yield was measured, and the weight average molecular weight (Mw) and number average molecular weight (Mn) of chitosan degradation products were analyzed by high performance gel exclusion chromatography . The specific analysis conditions are as follows, chromatographic column: TSK G5000-PWXL; mobile phase: 0.2M acetic acid / 0.1M sodium acetate solution; flow rate: 0.6mL / min; column ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to ocean chemical engineering technology and particularly relates to a method for preparing chitosan with an ultrahigh deacetylation degree under a low alkali concentration condition. The method comprises the following steps: with chitosan with deacetylation degree of 60-85% as raw material, carrying out high temperature and high pressure reaction under a low alkali concentration condition, washing the product to be neutral with deionized water after the reaction, filtering and drying to obtain chitosan with deacetylation degree higher than 95%. According to the method provided by the invention, the high temperature and high pressure reaction condition is beneficial for a deacetylation reaction to achieve continuous deacetylation on chitosan with medium and low deacetylation degree so as to prepare chitosan with ultrahigh deacetylation degree, and the application of the chitosan in fields such as medical treatment, food, chemical modification and the like is expanded.

Description

technical field [0001] The invention belongs to marine chemical engineering technology, and in particular relates to a method for preparing chitosan with ultra-high deacetylation degree under the condition of low alkali concentration. Background technique [0002] Chitosan is the product of de-N-acetylation of chitin. Generally speaking, chitosan can be called chitosan if more than 55% of N-acetylation is removed. Chitosan with a deacetylation degree of 55%-70% is a low degree of deacetylation, chitosan with a degree of deacetylation of 70%-85% can be used for industrial applications, and chitosan with a degree of deacetylation of 85%-95% Chitosan, 95%-100% is ultra-high deacetylation degree chitosan. Chitosan with N-deacetylation degree of 95%-100% is extremely difficult to prepare. The degree of deacetylation, that is, the content of free amino groups on the molecular chain, is an extremely important technical indicator. The degree of deacetylation is directly related to...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08
Inventor 邢荣娥何晓飞李克成刘松李鹏程
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap