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Chinese herb extract composition for treating functional gastrointestinal disorder or irritable bowel syndrome, preparation method and application of composition to preparation of medicine

A technology for irritable bowel syndrome and extracts, which is applied in the preparation of drugs for the treatment of functional gastrointestinal diseases or irritable bowel syndrome, and the field of preparation of compositions, which can solve the problem of incomplete clarity of effective substances in compound prescriptions and constraints on compound prescriptions Problems such as application effect and clinical curative effect instability, to achieve stable and controllable drug quality, enhanced pharmacological effects and clinical curative effect, and targeted effects of production quality control

Active Publication Date: 2014-04-23
NANJING XINTONG RUIYI MEDICINE SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Although the addition and subtraction of Atractylodes Rhizoma Atractylodes Rhizome, Radix Paeoniae Alba, Fangfeng, and Tangerine Peel have been clinically used to treat diseases such as intestinal dysfunction, functional dyspepsia, and irritable bowel syndrome, the effective substances of the compound are not completely clear, and the preparation technology is not advanced. In practical application, there are problems such as unstable clinical curative effect and inconvenience for patients to take
These problems have seriously restricted the application effect of the compound

Method used

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  • Chinese herb extract composition for treating functional gastrointestinal disorder or irritable bowel syndrome, preparation method and application of composition to preparation of medicine
  • Chinese herb extract composition for treating functional gastrointestinal disorder or irritable bowel syndrome, preparation method and application of composition to preparation of medicine
  • Chinese herb extract composition for treating functional gastrointestinal disorder or irritable bowel syndrome, preparation method and application of composition to preparation of medicine

Examples

Experimental program
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Effect test

Embodiment 1

[0200] Embodiment 1. The composition and the preparation thereof for treating gastrointestinal dysfunction and irritable bowel syndrome of the present invention.

[0201] Sample preparation method:

[0202] Atractylodes Rhizome Extract I: Take an appropriate amount of Atractylodes Rhizoma Atractylodes Rhizoma, crush it into a 20-mesh coarse powder, add 8 times the amount of water to soak for 3 hours, steam distillation for 6 hours, and collect the distillate to become Atractylodes Rhizoma Atractylodes Extract I. Atractylodes macrocephala extract I was added with 6 times of β-cyclodextrin, ground for 15 min, and dried in vacuum for later use.

[0203] Atractylodes Rhizome Extract II: use Atractylodes Rhizome coarse powder (16 mesh), water extraction twice, extraction temperature 85 ℃, 15 times water each time, extraction time 1 hour, stirring speed 30rpm. The extracts were combined, filtered, and concentrated to contain 1.0 g of crude drug per ml. The supernatant was added wi...

Embodiment 2

[0208] Example 2. The composition for treating irritable bowel syndrome and the preparation thereof of the present invention.

[0209] Sample preparation method:

[0210] Atractylodes Rhizome Extract I: Take Atractylodes Rhizoma Atractylodes Rhizome and crush it into a 16-mesh coarse powder, extract it with a supercritical carbon dioxide extractor, the extraction pressure is 28MPa, the extraction temperature is 37°C~38°C, the separation pressure is 6 MPa, and the separation temperature is 47°C~48°C. Carbon dioxide flow rate: 31~33L / h, extraction time: 120 min; collect the extract as Atractylodes macrocephala extract I.

[0211]Atractylodes Rhizome Extract II: use Atractylodes Rhizoma Rhizoma Atractylodes Extract I and the water extract, extract twice with water, extraction temperature 90°C, 1 hour each time, 8 times the water, combine the extracts, filter, and concentrate to 1 ml Containing 1.0 g of crude drug, take the supernatant and add 3 times the amount of 95% ethanol, ...

Embodiment 3

[0216] Example 3 Preparation of the composition for treating irritable bowel syndrome and its preparation of the present invention.

[0217] Atractylodes Rhizome Extract I: Take an appropriate amount of Atractylodes Rhizoma Atractylodes Rhizoma, crush it into a 16-mesh coarse powder, add 8 times the amount of water to soak for 3 hours, steam distillation for 6 hours, and collect the distillate to become Atractylodes Rhizome Extract I. Take the above extract, add 6 times the amount of β-cyclodextrin, grind it in a colloid mill for 30 min, and dry the ground product in vacuum for later use.

[0218] Atractylodes Rhizome Extract II: use Atractylodes Rhizoma Rhizoma Atractylodes Extract I and the water extract, extract twice with water, extraction temperature 90°C, 1 hour each time, 8 times the water, combine the extracts, filter, and concentrate to 1 ml Containing 1.0 g of crude drug, take the supernatant and add 3 times the amount of 95% ethanol, let it stand, filter, and collec...

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Abstract

The invention discloses a Chinese herb extract composition for treating functional gastrointestinal disorder or irritable bowel syndrome, a preparation method and application of the composition to preparation of a medicine. The Chinese herb extract composition comprises the following Chinese medicinal herb extracts in parts by weight: 13-29 parts of langehead atractylodes rhizome extract I, 18-57 parts of langehead atractylodes rhizome extract II, 13-53 parts of radix paeoniae alba extract, 6-32 parts of pericarpium citri reticulatae extract and 2-27 parts of divaricate saposhnikovia root extract, wherein the langehead atractylodes rhizome extract I is an extract of a distillation method or supercritical extraction method; the langehead atractylodes rhizome extract II is a water extract; the radix paeoniae alba extract is an alcohol extract; the pericarpium citri reticulatae extract is an alcohol extract; the divaricate saposhnikovia root extract is an aqueous extract or supercritical extract. According to the Chinese herb extract composition, the conventional view that co-decocting or total extracting of a Chinese herbal compound is superior to respective extracting of each Chinese medicinal herb is overcome, the pharmacological effect is remarkably improved through optimized combined treatment of each Chinese medicinal herb extract, and the quality control of the composition is facilitated. The Chinese herb extract composition for treating functional gastrointestinal disorder or irritable bowel syndrome, disclosed by the invention, has an unexpected effect.

Description

technical field [0001] The invention relates to a composition of traditional Chinese medicine extracts for treating functional gastrointestinal diseases (FGIDs) or irritable bowel syndrome (IBS), and the preparation of the composition for treating functional gastrointestinal diseases or irritable bowel syndrome method; and the application of the composition for treating functional gastrointestinal disease or irritable bowel syndrome in the preparation of medicines for treating functional gastrointestinal disease or irritable bowel syndrome. Background technique [0002] Functional gastrointestinal diseases (FGIDs) are a group of digestive system diseases that have gastrointestinal symptoms, but no organic diseases or abnormal biochemical structures can be found after examination. Patients often experience symptoms such as loss of appetite, early satiety, abdominal pain, nausea, vomiting, abdominal distension, diarrhea, constipation, and difficulty in defecation. Accord...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61P1/00
Inventor 杨星昊
Owner NANJING XINTONG RUIYI MEDICINE SCI & TECH
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