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Pharmaceutical composition for treating allergic rhinitis in children and preparation method thereof

A technology for allergic rhinitis and composition, which is applied in the field of pharmaceutical composition for treating allergic rhinitis in children and its preparation, and can solve problems such as adverse reactions affecting application

Active Publication Date: 2016-07-06
LIUZHOU CITY HEALTHCARE HOSPITAL FOR WOMEN & CHILDREN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, the World Health Organization "Allergic Rhinitis and Its Impact on Asthma" (ARIA) working group recommends a stepwise treatment plan for the treatment of this disease, but concerns about the possible adverse reactions of drugs such as glucocorticoids and antihistamines affect other drugs. Application in children, especially children under 5 years old

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Embodiment 1: Preparation of granules (Scheme 1)

[0080] Take Xanthium 6g, Xinyi flower 6g, Angelica dahurica 5g, Bupleurum 9g, Fangfeng 6g, licorice 6g, Houttuynia cordata 12g, forsythia 9g, mountain silver flower 9g, almond 6g, bellflower 6g, dandelion 12g, mint 6g, fried Malt 6g, Fried Guya 6g, Divine Comedy 9g, Morus alba 9g, extract all medicinal materials except mint and add water for 3 times. After 3 hours, 2 hours, and 1 hour, combine the extracts, filter, and concentrate the filtrate to a clear paste with a relative density of 1.10 at 80°C; add water twice the weight of the medicinal materials to mint, extract for 20 minutes, filter, and the filtrate and the above clear paste Mix evenly, add sucrose powder and dextrin, mix evenly, granulate, dry, granulate, pack separately, and obtain.

Embodiment 2

[0081] Embodiment 2: Preparation of granules (Scheme 4)

[0082] Take 3g cocklebur, 3g magnolia, 3g angelica, 5g bupleurum, 3g fangfeng, 3g licorice, 10g houttuynia, 7g forsythia, 7g mountain silver flower, 5g almond, 5g bellflower, 10g dandelion, 5g mint, stir-fry Malt 5g, Chaoguya 5g, Divine Comedy 7g, Morus alba 7g, reflux extraction with 40% ethanol for 3 times, the amount of ethanol each time is 10 times, 8 times, 4 times of the total amount of medicinal materials, and the extraction time is 4 hours, After 2 hours and 1 hour, the extracts were combined, filtered, and the filtrate was concentrated to an extract with a relative density of 1.25 at 60°C to obtain the active ingredient. Add lactose, starch, granulate, dry, granulate, and pack to obtain the product.

Embodiment 3

[0083] Embodiment 3: the preparation of syrup (scheme two)

[0084] Take Xanthium 7g, Xinyi flower 7g, Angelica dahurica 6g, Bupleurum 11g, Fangfeng 7g, licorice 5g, Houttuynia cordata 15g, forsythia 11g, mountain silver flower 11g, almond 7g, bellflower 7g, dandelion 15g, mint 7g, fried Malt 7g, Fried Guya 7g, Divine Comedy 11g, Morus alba Cortex 11g, extract all the medicinal materials except mint and add water for 3 times, the amount of water added for the three times is equivalent to 12 times, 8 times, and 6 times the total weight of the medicinal materials, and the extraction time for each time Combine the extracts for 3 hours, 2 hours, and 1 hour respectively, filter, concentrate the filtrate to a clear paste with a relative density of 1.20 at 70°C, add ethanol to make the alcohol content 40%, let stand for 24 hours, filter, When the filtrate is concentrated to an extract with a relative density of 1.10 at 80°C; peppermint is added with water 5 times the weight of the me...

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PUM

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Abstract

The invention relates to a pharmaceutical composition for treating infantile anaphylactic rhinitis and a preparation method of the pharmaceutical composition. The traditional Chinese medicine is prepared from cocklebur fruit, magnolia flower, radix angelicae, radix bupleuri, radix sileris, liquorice, herba houttuyniae, fructus forsythiae, flos lonicerae, almond, platycodon grandiflorum, dandelion, mint, roasted malt, roasted rice sprout, medicated leaven and cortex mori radicis. The drug has the effects of clearing heat and detoxifying, ventilating lung and dispelling wind, expelling pus and dredging collaterals, and regulating the lung and the spleen, and is accurate in curative effect and superior to the prior art in effect in the aspect of treatment of the infantile anaphylactic rhinitis.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a pharmaceutical composition for treating allergic rhinitis in children and a preparation method thereof. Background technique [0002] With the increasing complexity of modern urban life, there are many impurities and allergens that are incompatible with the human body, such as automobile exhaust, dust, pollen, cosmetics, decoration materials, food mildew and air pollution, which make allergic diseases Rates and deaths are on the rise. Allergic rhinitis is common in pediatric outpatient clinics, and its incidence has been on the rise in recent years. It often occurs repeatedly due to factors such as colds and colds, and the course of the disease is prolonged, which affects children's study and life. [0003] Allergic rhinitis belongs to the category of "nasal sneezing" and "sneezing" in traditional Chinese medicine. "Su Wen·Mai Jie Pian" clarified the disease name of rhinorrhea, the m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8998A61P11/02A61P37/08
Inventor 肖萍曾定元罗荔东陈慧诸葛明丽孙艳
Owner LIUZHOU CITY HEALTHCARE HOSPITAL FOR WOMEN & CHILDREN