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Agent for improving quality of sleep

A sleep quality improving agent technology, which is applied in pill delivery, drug combination, nervous system diseases, etc., can solve the problems of inconvenient sleep quality improving agent and insufficient improvement of sleep quality, and achieve the effect of ensuring safety

Inactive Publication Date: 2014-06-04
LION CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, S-adenosylmethionine p-toluenesulfonate disulfate has no effect on sleep latency, and the improvement of sleep quality cannot be said to be sufficient.
Furthermore, only intravenous injection and intramuscular injection are given as administration methods, and appropriate training for injection is required, and there are problems in terms of invasiveness due to pain during injection, and strict management of preparations is required from the aspect of microorganisms, etc., as improvements in sleep quality. The agent is very inconvenient in actual use

Method used

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  • Agent for improving quality of sleep
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  • Agent for improving quality of sleep

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 and comparative example 1～5

[0070] 1. Evaluation of sleep-inducing effect (Example 1 and Comparative Examples 1-5: Measurement of activity level of mice)

[0071] In order to confirm the sleep-inducing effect of S-adenosylmethionine-containing yeast, the following tests were performed using each sample shown in Table 1.

[0072] As the S-adenosylmethionine-containing yeast (sample of Example 1), "AMee (trade name)" manufactured by Iwata Chemical Industry Co., Ltd. was used. As the yeast not containing adenosylmethionine (the sample of Comparative Example 2), "Nissin Super Camellia Dried Yeast (Nissin Super Camellia Dried Yeast) (trade name)" manufactured by Nissin Foods Co., Ltd. was used. S-adenosylmethionine p-toluenesulfonate disulfate (sample of Comparative Example 3) was used S-adenosylmethionine p-toluenesulfonate disulfate manufactured by CHEMaster. The mixture of S-adenosylmethionine-free yeast and S-adenosylmethionine p-toluenesulfonate disulfate (the sample of Comparative Example 4) used the s...

Embodiment 2 and comparative example 6

[0084] 2. Evaluation 1 of improvement effect of sleep quality (Example 2 and Comparative Example 6: Electroencephalogram measurement in mice)

[0085] In order to confirm the effect of S-adenosylmethionine-containing yeast on sleep quality, the following test was performed to measure brain waves. That is, electrodes were attached to the head of the mouse, brain waves of the mouse during free movement were recorded in an isolation room for recording, and each time of "wakefulness", "REM sleep" and "non-REM sleep" was measured.

[0086] 8-week-old male C57BL / 6 mice purchased from Japan SLC were equipped with electrodes for electroencephalogram and electromyography. After installing the electrodes, recover in the recovery isolation room for 10 days. Thereafter, it was moved into an isolation room for recording, and the wires were connected. After confirming whether the brain waves can be judged using the brain wave analysis software SleepSign (registered trademark) VER3.0 (KISS...

Embodiment 3 and comparative example 7

[0092] 3. Evaluation 2 of the improvement effect of sleep quality (Example 3 and Comparative Example 7: Measurement of human brain wave and investigation of sleep feeling)

[0093] In order to confirm the effect of S-adenosylmethionine-containing yeast on human sleep quality, the following tests were performed using each sample shown in Table 3.

[0094] As a sample of Example 3, tablets (S-adenosylmethionine content in 9 tablets: 88 mg) in which S-adenosylmethionine-containing yeast was mixed were prepared. In addition, as a sample of Comparative Example 7, a yeast placebo tablet containing no S-adenosylmethionine was prepared. The detailed compositions are shown in Table 3.

[0095] table 3

[0096] Table 3 (composition of tablets)

[0097]

[0098] The Pittsburgh (Japanese: ピッツバーグ) sleep questionnaire was used to conduct a survey in advance, and 12 adult males and females with poor sleep status were selected as participants. These 12 participants orally ingested the ...

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Abstract

The purpose of the present invention is to provide an agent for improving the quality of sleep, that sufficiently achieves an improvement effect on the quality of sleep, exhibits an effect regardless of the type of administration even if orally administered, and for which physical safety is guaranteed. This invention provides: an agent for improving the quality of sleep, having as the effective component thereof an S-adenosylmethionine-containing yeast; and a composition for improving the quality of sleep, containing said agent for improving the quality of sleep.

Description

technical field [0001] The invention relates to an agent for improving sleep quality. Background technique [0002] There are roughly two types of sleep: non-rapid eye movement sleep (Japanese: ノンレム sleep), in which brain activity almost stops, and rapid eye movement sleep (Japanese: レム sleep), in which a part of the brain is still actively active and dreaming even though the whole body is in a state of weakness. . These two sleeps are repeated at certain intervals to form sleep ( figure 1 ). In high-quality sleep, the time from bedtime to non-REM sleep (sleep latency) is short, and it is necessary to ensure sufficient non-REM sleep time and deep non-REM sleep, especially sufficient deep non-REM sleep at the beginning of sleep. REM sleep. [0003] However, in recent years, with the progress of 24-hour socialization, the average sleep time of Japanese people has been greatly reduced, and at the same time, the number of patients complaining of sleep dissatisfaction is incr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/06A61P25/20A61K31/7076
CPCA61K36/06A61K9/0053A61K31/7076A61K9/2009A61K9/2018A61K9/2054A61K9/4858A61K35/741A61P25/20
Inventor 里出良博五木田智夫镰田育子铃木究村越伦明
Owner LION CORP