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Application of baicalin in preparation of medicine for treating ricin poisoning

A technology of ricin and baicalin, which is applied in the directions of drug combination, antidote, pharmaceutical formula, etc., can solve problems such as no effective antidote for ricin.

Active Publication Date: 2014-06-18
JILIN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The US Centers for Disease Control and Prevention lists it as a bioterrorism category B, but there is no effective antidote for ricin in clinical practice

Method used

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  • Application of baicalin in preparation of medicine for treating ricin poisoning
  • Application of baicalin in preparation of medicine for treating ricin poisoning
  • Application of baicalin in preparation of medicine for treating ricin poisoning

Examples

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Embodiment Construction

[0018] The application of the baicalin of the present invention in the preparation of medicine for treating ricin poisoning.

[0019] Baicalin (Baicalin) is a flavonoid compound extracted and isolated from plants such as Chinese medicine Scutellaria baicalensis and wood butterfly. It has obvious antifungal activity, especially selective effect on yeast, and the minimum inhibitory concentration (MIC) is 70 Between -100μg / ml, the specific molecular formula is as follows:

[0020]

[0021] Baicalin can inhibit cell death caused by ricin at the cellular level, and has an obvious rescue effect on ricin poisoning in mice. Studies have shown that baicalin can be used in the preparation of drugs for treating ricin poisoning.

[0022] The above-mentioned medicine for treating ricin poisoning is injection or capsule or tablet or powder injection.

[0023] Regardless of whether ricin poisoning is caused by inhalation, ingestion or injection, the above-mentioned medicines containing b...

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Abstract

The invention discloses application of baicalin in preparation of a medicine for treating ricin poisoning. Baicalin can inhibit cell death caused by ricin at a cellular level, and also has an obvious relief role of ricin poisoning in mice in vivo. The study shows that the baicalin can be applied to preparation of the medicine for treating ricin poisoning. The application provided by the invention has the beneficial effects that the baicalin can inhibit cell death caused by ricin at a cellular level, and also has a great significance for relief of ricin poisoning, and the baicalin containing medicine has an exact curative effect on ricin poisoning caused by inhaling, or eating or injection.

Description

technical field [0001] The invention relates to the application of a medicine in the preparation of a medicine for treating ricin poisoning, in particular to the application of baicalin in the preparation of a medicine for treating ricin poisoning. Background technique [0002] Ricin is a highly toxic protein extracted from castor seeds. It belongs to the type II ribosome inactivating protein family and has N-glycosidase activity. It can organize protein synthesis in mammalian cells and cause cell apoptosis and death. Therefore, ricin has been used as a biological warfare agent since the early 20th century. Due to its high toxicity, easy extraction and high stability, it is easy to be used by terrorist organizations and poses a great threat to human life. The U.S. Centers for Disease Control and Prevention lists it as a bioterrorism class B, but there is no effective antidote for ricin in clinical practice. Therefore, the study of small molecule antagonists that can antagon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P39/02
CPCA61K31/7048A61P39/02
Inventor 邓旭明饶子和董靖李雪梅张勇陈瑜涛邱家章
Owner JILIN UNIV
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