A drug-loaded micelle that improves the bioavailability of ursolic acid and its structural modifications

A technology of drug-loaded micelles and ursolic acid, which is applied in the field of biofunctional materials and nanometers, can solve the problems that the solubility has not been significantly improved, the average particle size of drug-loaded micelles is large, and the requirements for equipment are high, so as to achieve stable and reliable drug loading Quantity, improve bioavailability, low equipment requirements
CN103877022BInactive Publication Date: 2016-06-01FUZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
FUZHOU UNIV
Publication Date
2016-06-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the fields of biological functional materials and nanotechnologies and particularly relates to a novel amphiphilic polymer nano medicine carrying micelle which is proper in particle size distribution range, stable in encapsulation rate and medicine carrying rate, high in biological safety and capable of increasing bioavailability of ursolic acid and a structural modifier thereof. The technical scheme of the invention provides a medicine carrying micelle capable of increasing bioavailability of ursolic acid and a structural modifier thereof. The medicine carrying micelle is characterized in that the preparation method comprises the following steps of 1, synthesizing PLGA-PEG-PLGA (poly(lactic-co-glycolic acid)-polyethylene glycol-poly(lactic-co-glycolic acid)) by using a ring opening polymerization method; 2, simultaneously dissolving an insoluble drug and a triblock copolymer into an organic solvent to prepare an oil phase; 3, dropwise adding the oil phase into a water phase stirred at a high speed; 4, stirring until the oil phase is completely volatilized, and filtering a membrane in the solution to obtain a medicine carrying nanoparticle contained ultrapure water solution; freezing and drying to obtain the medicine carrying micelles.
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Description

technical field

[0001] The invention relates to the field of biofunctional materials and nanotechnology, in particular to a new type of ursolic acid with suitable particle size distribution range, stable encapsulation rate and drug loading rate, high biological safety, and can improve the bioavailability of ursolic acid and its derivatives Amphiphilic polymer nano drug-loaded micelles. Background technique

[0002] In recent years, Ursolic acid (Ursolic acid, UA), a natural source of pentacyclic triterpenoids, has attracted domestic and foreign research due to its wide range of biological activities, such as anti-tumor, liver protection, anti-inflammation, anti-virus, and anti-oxidation. attention. Especially for its remarkable anti-cancer effect and good liver protection effect, it has been valued. Pharmacological experimental studies have proved that UA has: 1) inhibition of malignant tumor cell proliferation; 2) induction of tumor cell differentiation and apoptosis; 3) ...

Claims

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