A kind of anti-cancer nano drug loaded with arsenic agent and its preparation method
A nano-drug and nano-sphere technology, applied in pharmaceutical formulations, anti-tumor drugs, drug combinations, etc., can solve problems such as unfavorable drug efficacy and fast metabolism, and achieve the effects of easy scale-up preparation, simple process steps, and convenient operation.
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Embodiment 1
[0032] Example 1: Preparation of hollow silica nanomaterials with a radius of 30 nm
[0033]In a 50 mL round bottom flask, 60 mg of iron oxide nanoparticles with uniform particle size distribution were added and dissolved in 20 mL of cyclohexane, while 900 μL of Co-520, 200 μL of tetraethoxysilane and 400 μL of ammonia were added. The mixed solution was stirred (800 rpm), mixed evenly, and kept at this speed for reaction for 16 h. Then, 10 μL of 3-aminopropyltriethoxysilane was added to the reaction liquid and reacted for 2 h. After the reaction was completed, about 1 mL of absolute ethanol was added dropwise to the reaction liquid and centrifuged at 5000 rpm for 2 min. The resulting precipitate was redissolved in 10 mL of ultrapure aqueous solution to obtain hollow silica nanoparticles with a radius of 30 nm (see figure 2 ). figure 1 A schematic diagram of the anticancer nanomedicine loaded with arsenic agent according to the present invention is given.
Embodiment 2
[0034] Example 2: Ni,As@SiO 2 Preparation of anticancer nanomedicine
[0035] Add 2 mL of hollow silica nanoparticle solution with a concentration of 10 mg / mL and 3 mL of 600 mM nickel acetate solution in a 10 mL round bottom flask. The mixed solution was placed in a water bath at 50°C and an ice-water bath at 0°C in sequence, and circulated 10 times. After 10 cycles were completed, the excess nickel acetate solution was discarded by centrifugation (14000 rpm), and 3 mL of 150 mM ATO aqueous solution (pH 8) was added thereto. The mixture was placed in a 50°C water bath for 6h. After the reaction is complete, centrifuge at 14000rpm for 30min, add 2mL ultrapure water to dissolve the precipitate, and obtain Ni,As@SiO 2 Anticancer nanomedicines (see image 3 and 4 ).
Embodiment 3
[0036] Example 3: Mn,As@SiO 2 Preparation of anticancer nanomedicine
[0037] Add 2 mL of hollow silica nanoparticle solution with a concentration of 10 mg / mL and 3 mL of 600 mM manganese chloride solution in a 10 mL round bottom flask. The mixed solution was placed in a water bath at 50°C and an ice-water bath at 0°C in sequence, and circulated 10 times. After 10 rounds of cycles were completed, the excess manganese chloride solution was discarded by centrifugation (14000 rpm), and 3 mL of 150 mM ATO aqueous solution (pH 8) was added thereto. The mixture was placed in a 50°C water bath for 6h. After the reaction is complete, centrifuge at 14000rpm for 30min, add 2mL ultrapure water to dissolve the precipitate, and obtain Mn,As@SiO 2 Anticancer nanomedicines (see Figure 5 ).
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