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High-sensitivity nanometer cobalt oxide-doped talampicillin molecular imprinting electrochemical sensor and preparation method thereof

A technology of nano-cobalt oxide and phthalmidine, applied in the direction of material electrochemical variables, etc., can solve the problems of improper matching between functional monomers, template molecules and cross-linking agents, poor cross-linking rigidity, and low sensitivity, and achieve excellent sensitivity , easy to make, simple equipment

Inactive Publication Date: 2014-07-16
GUANGXI UNIV FOR NATITIES
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Problems solved by technology

The current method is not sensitive due to the inappropriate matching of selected functional monomers with template molecules and cross-linking agents, and the rigidity of cross-linking is also poor.

Method used

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  • High-sensitivity nanometer cobalt oxide-doped talampicillin molecular imprinting electrochemical sensor and preparation method thereof

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Embodiment 1

[0014] 1. Treatment of glassy carbon electrodes

[0015] Polish the glassy carbon electrode on a polishing cloth with 1.0 μm, 0.3 μm and 0.05 μm alumina powder in sequence, then put it into nitric acid with a volume ratio of 1:1 for 6 minutes, then put it into absolute ethanol for 6 minutes, and finally Ultrasonic cleaning with pure water.

[0016] 2. Preparation of molecularly imprinted electrochemical sensor for paracetamol

[0017] To 10.0mL solvent ethanol, add 0.20mmol ~ 0.60mmol template molecule thalidomide, 2.0mmol ~ 5.0mmol functional monomer N-tert-butyl-2α-hydroxy-5α-androsten-3-one -17β-formamide, 2.5mmol cross-linking agent maleic rosin ethylene glycol acrylate, 0.9mmol initiator azobisisobutyronitrile and 10.0mg~60.0mg nano-cobalt oxide, each chemical reagent added ultrasonically dissolved 9 minute;

[0018] Take 9 μL of the mixture in step and apply it on the surface of a clean and smooth glassy carbon electrode. After standing for 12 hours, the modified...

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Abstract

The invention discloses a high-sensitivity nanometer cobalt oxide-doped talampicillin molecular imprinting electrochemical sensor and a preparation method thereof. Talampicillin serves as a template molecule, N-tert-butyl-2alpha-hydroxyl-5alpha-androstene-3-ketone-17beta-formamide serves as a functional monomer, azodiisobutyronitrile serves as an initiator, nanometer cobalt oxide serves as a doping agent, and maleated rosin ethylene glycol acrylate synthesized by taking rosin as a raw material serves as a crosslinking agent, so as to prepare a high-sensitivity nanometer cobalt oxide-doped talampicillin molecular imprinting electrochemical sensor. The analytical method is simple and practical, and the defects that the previous analytical method is complex, expensive in equipment and low in sensitivity are overcome.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a high-sensitivity nano cobalt oxide-doped thalidomide molecularly imprinted electrochemical sensor and a preparation method thereof. Background technique [0002] Ampicillin, alias: ampicillin phthalate, ampicillin, indications of ampicillin, mainly treat diseases including respiratory system, urinary system and intestinal infection caused by sensitive bacteria. However, long-term use or overdose of these drugs can cause dizziness, tinnitus, and renal and hepatic insufficiency. [0003] The methods for the determination of thalidomide include high performance liquid chromatography, chromatography-mass spectrometry, etc. However, these methods have the disadvantages of requiring expensive equipment, high cost, long time consumption, and low sensitivity; therefore, it is of great significance to study a highly sensitive and simple method for the detection of phtha...

Claims

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Application Information

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IPC IPC(8): G01N27/30
Inventor 谭学才雷福厚韦贻春李浩余会成陈其锋
Owner GUANGXI UNIV FOR NATITIES
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