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A pharmaceutical composition for reducing serum triglyceride and its application

A technology of triglycerides and medicines, which is applied in the field of medicine, can solve the problems of not discovering isoviolet dione, lowering serum triglycerides or weight loss activity, etc., and achieve the effect of lowering triglyceride levels

Inactive Publication Date: 2017-03-01
周杰华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] By searching the domestic and foreign literature, there is no literature report on the activity of reducing serum triglycerides or weight loss by isocorydadione

Method used

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  • A pharmaceutical composition for reducing serum triglyceride and its application
  • A pharmaceutical composition for reducing serum triglyceride and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The high-fat feed was prepared according to the following formula: 1 kg of casein, 15 g of L-cysteine, 0.75 kg of maltodextrin, 0.35 kg of sucrose, 0.25 kg of cellulose, 0.15 kg of soybean oil, and 1.25 kg of lard. Select 4-week-old Kunming mice, half male and half female, fed with prepared high-fat diet, and drink water normally. After 10 weeks of feeding, mice weighing less than 60g were eliminated, and then divided into model control group and isocordiadione intervention groups, 10 rats in each group, half male and half male. Among them, according to the body weight of the rats, the rats in the isocordiadione intervention group were given 500 mg / kg / d of isocordiadione by intragastric administration, and the high-fat feed was still fed during the administration period, and the rats were intragastrically administered once a day in the morning and evening, respectively. 8 consecutive weeks. Rats in the model control group were given intragastric administration of the s...

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PUM

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Abstract

The invention discloses a medicine combination for reducing triglyceride in serum and application thereof. The medicine combination is prepared from active ingredients and auxiliary materials, wherein the active ingredients include isocoydione. Isocoydione is capable of reducing the triglyceride level of patients with obesity, and reducing weight after being taken for a long time, thus achieving the effect of losing weight.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for lowering serum triglyceride and its application. Background technique [0002] Obesity refers to a certain degree of obvious overweight and thick fat layer, which is a state caused by excessive accumulation of body fat, especially triglycerides. Excessive body fat accumulation due to excessive food intake or changes in body metabolism results in excessive weight gain and causes human pathology, physiological changes or latency. Obesity is a cause of cardiovascular disease, especially coronary heart disease. The content of plasma triglyceride and low-density lipoprotein particles in obese patients increased, and the concentration of high-density lipoprotein particles was low. When the body weight returned to normal levels, the concentrations of plasma triglycerides and lipoproteins returned to normal levels. [0003] Isocorydione (Is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/473A61P3/06A61P3/04
Inventor 周杰华王英英
Owner 周杰华