Therapeutic agent-containing contact lenses and preparation method thereof

A contact lens and therapeutic agent technology, applied in glasses/goggles, optics, instruments, etc., can solve problems such as exacerbation of the disease, and achieve the effects of increasing air permeability, enhancing interaction, and high oxygen permeability

Active Publication Date: 2014-07-23
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although the contact lenses currently on the market can correct vision and beautify the eyes, yet, when the eyes have certain discomfort or disease, insisting on wearing contact lenses may aggravate the condition.

Method used

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  • Therapeutic agent-containing contact lenses and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0026] The preparation method of the contact lens containing the therapeutic agent of the present application, its one embodiment, comprises the following steps:

[0027] Step 102 : adding colloidal photonic crystal particles to the prepolymer solution to prepare a mixed solution.

[0028] Colloidal photonic crystals can be obtained by self-assembly of monodisperse microspheres. Specifically, it can be prepared by self-assembly by gravity sedimentation, electrostatic force or capillary force. The shape of the prepared colloidal photonic crystal includes self-sphere, hemisphere, ellipsoid, cylinder or flake.

[0029] The shape of the colloidal photonic crystal includes any combination of one or more of self-spherical, hemispherical, ellipsoidal, cylindrical, and flakes. The shape of the flakes can be regular or irregular. Colloidal photonic crystals range in size from 50 nanometers to 600 micrometers.

[0030] Monodisperse microspheres include any combination of one or ...

Embodiment 1

[0048] 1. Preparation of colloidal photonic crystal particles:

[0049] 10 mL of monodisperse polystyrene microspheres with a diameter of 180 nm were prepared into an emulsion with a mass concentration of 4.0 wt%, and then dispersed into 100 mL of n-hexadecane containing the surfactant Hypermer 2296 (with a mass fraction of 2.0 wt%). In alkane, the colloidal photonic crystal particles can be obtained by self-assembly in an oven at 50 °C for 72 hours. Then, the colloidal photonic crystal particles are fully washed with n-hexane to remove n-hexadecane, and then dried to obtain the colloidal photonic crystal particles. The colloidal photonic crystal particles were dispersed in a mixed solution of hydroxyethyl methacrylate and methylene bisacrylamide (molar ratio 30:1), and Irgacure 2959 (mass volume ratio was 0.5%) was used as the initiator.

[0050] 2. Curing treatment of the prepolymer solution:

[0051] A volume of 100 microliters of the prepolymer solution mixed with coll...

Embodiment 2

[0057] 1. Preparation of colloidal photonic crystal particles:

[0058] The monodisperse silica microspheres with diameters of 180 nanometers, 220 nanometers and 320 nanometers were self-assembled to prepare colloidal photonic crystal films by self-assembly, and many tiny colloidal photonic crystal fragments could be obtained by tapping the film. Then, the colloidal photonic crystal fragments assembled by microspheres of different sizes were mixed and dispersed into a mixed solution of hydroxyethyl methacrylate and methylene bisacrylamide (molar ratio 30:1), with Irgacure 2959 (mass volume ratio of 0.5%) ) is an initiator and contains 30% anti-inflammatory agent.

[0059] 2. Curing treatment of the prepolymer solution:

[0060] 100 microliters of the above-mentioned prepolymer solution mixed with colloidal photonic crystal particles was added to the mold for contact lens preparation, and irradiated with an ultraviolet lamp (400W) at 0°C for 1 hour to cure to obtain a prelim...

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Abstract

The invention discloses a preparation method of therapeutic agent-containing contact lenses. The preparation method comprises the following steps: adding colloid photonic crystal particles to a precursor solution so as to prepare a mixed solution; adding the mixed solution to a contact lens mold, and curing so as to obtain primary contact lenses; putting and soaking the primary contact lenses in therapeutic agent-containing normal saline, thus obtaining the contact lenses. The invention also discloses the therapeutic agent-containing contact lenses. In the specific mode of execution, the precursor solution containing the colloid photonic crystal particles is added to the contact lens mold and is cured so as to prepare the primary contact lenses, then the primary contact lenses are put and soaked in the therapeutic agent-containing normal saline so as to obtain the contact lenses, so that the contact lenses have the effects of correcting vision and beautifying eyes, the oxygen permeation amount of the contact lenses is high, and the contact lenses have the effect of easing eyes when the eyes are uncomfortable or ill.

Description

technical field [0001] The present application relates to the technical field of contact lenses, in particular to a contact lens containing a therapeutic agent and a preparation method thereof. Background technique [0002] With the development of science and technology and the improvement of living standards, people's pursuit of practicality, beauty and safety has become increasingly strong. In the past few decades, the market demand for contact lenses has been greatly expanded, occupying the market of traditional frame glasses and gradually becoming a kind of Trendy, convenient elements are taking the world by storm. According to incomplete statistics, in the past 30 years, the total number of people wearing contact lenses in the world has increased by 35 times, and this data is still increasing day by day. [0003] Contact lenses can not only correct vision, but also add some pigments or pigments in the preparation process to prepare colored contact lenses with specific ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/40C08J9/26G02C7/04
Inventor 杜学敏吴天准
Owner SHENZHEN INST OF ADVANCED TECH
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