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Natural medicine extract for treating arthritis and its application in preparation of medicine or health products

An extract and osteoarthritis technology, applied in the field of natural medicine extracts, can solve the problems of expensive western medicine, poor compliance of elderly patients, and large gastrointestinal reactions

Active Publication Date: 2015-11-11
GANSU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine treatment is currently mainly based on non-steroidal anti-inflammatory drugs, but the price of western medicine is relatively expensive, long-term use causes gastrointestinal reactions, and elderly patients have poor compliance

Method used

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  • Natural medicine extract for treating arthritis and its application in preparation of medicine or health products
  • Natural medicine extract for treating arthritis and its application in preparation of medicine or health products
  • Natural medicine extract for treating arthritis and its application in preparation of medicine or health products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] (1) Grind 20kg of dried Cordica japonica, add 10 times the amount of 70% ethanol, reflux extraction in a water bath at 65°C for 3 times, each time for 75min, combine the extracts, recover the ethanol, and obtain the extract Ⅰ;

[0105] (2) Dissolve the extract I in water, centrifuge, collect the supernatant to obtain the supernatant II; the supernatant II is purified by column chromatography with AB-8 macroporous adsorption resin, and the diameter-to-height ratio of the resin column is 1 : 8, sample loading volume 7BV, flow velocity is 3BV / h, respectively with deionized water, 10% ethanol solution, 20% ethanol solution eluting macroporous resin, eluent abandons, with 30% ethanol as eluent 7BV Elution and collection of eluate to obtain eluate III; concentrating eluate III and drying to obtain 5.4 g of Saffron Japonica extract.

Embodiment 2

[0107] (1) Grind 20kg of dried Cordica japonica, add 5 times the amount of 80% ethanol, and reflux extract in a water bath at 60°C for 4 times, each time for 70 minutes, combine the extracts, recover the ethanol, and obtain the extract Ⅰ;

[0108] (2) Dissolve the extract I in water, centrifuge, collect the supernatant to obtain the supernatant II; the supernatant II is purified by column chromatography with AB-8 macroporous adsorption resin, and the diameter-to-height ratio of the resin column is 1 : 9, sample loading volume 6BV, flow velocity is 4BV / h, with deionized water, 10% ethanol solution, 20% ethanol solution eluting macroporous resin respectively, eluent abandons, with 30% ethanol as eluent 5BV Elution and collection of the eluate to obtain eluate III; concentrating the eluate III and drying to obtain 5.2 g of Saffron Japonica extract.

Embodiment 3

[0110] (1) Grind 20kg of dried Cordica japonica, add 15 times the amount of 60% ethanol, reflux extraction in a water bath at 70°C for 2 times, each time for 80 minutes, combine the extracts, recover ethanol, and obtain the extract Ⅰ;

[0111] (2) Dissolve the extract I in water, centrifuge, collect the supernatant to obtain the supernatant II; the supernatant II is purified by column chromatography with AB-8 macroporous adsorption resin, and the diameter-to-height ratio of the resin column is 1 : 7, sample loading volume 8BV, flow velocity is 2BV / h, respectively with deionized water, 10% ethanol solution, 20% ethanol solution eluting macroporous resin, eluent abandons, with 30% ethanol as eluent 8BV Elution was carried out, and the eluate was collected to obtain eluate III; the eluate III was concentrated and dried to obtain 5.5 g of Saffron Japonica extract.

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Abstract

The invention belongs to the field of natural medicine extracts and relates to an oxygraphis glacialis extract for treating osteoarthritis. The oxygraphis glacialis extract for treating the osteoarthritis is prepared by adopting a method comprising the following steps: (1) smashing dried oxygraphis glacialis, adding 5-15 times amount of 60-80% ethanol, carrying out water bath and reflux extraction for 70-80 minutes for 2-4 times at the temperature of 60-70 DEG C, putting extract solutions together, and recycling ethanol, so that an extract I is obtained; (2) adding the extract I into water, dissolving, centrifuging, and collecting supernate, so that supernate II is obtained; carrying out column chromatographic purification on the supernate II by adopting an AB-8 type macroporous adsorption resin, wherein diameter-height ratio of a resin column is 1:(7-9), sampling volume is 6-8BV, and flow rate is 2-4BV / h; respectively eluting the macroporous adsorption resin with deionized water, 10% ethanol solution and 20% ethanol solution, removing away eluate, eluting by taking 30% ethanol as a 5-8BV eluant, and collecting the eluate, so that eluate III is obtained; concentrating and drying the eluate, so that the oxygraphis glacialis extract for treating the osteoarthritis is obtained.

Description

technical field [0001] The invention belongs to the field of natural medicine extracts, and relates to an extract of Saffron japonicus for treating osteoarthritis. Background technique [0002] Knee osteoarthritis, also known as knee degenerative arthritis, is a common disease characterized by degenerative changes in articular cartilage, aseptic, chronic, and progressive invasion of bone, including synovium and joint capsule. All-round, multi-level, and varying degrees of chronic inflammatory arthropathy in other structures of the joint. Epidemiological surveys show that the incidence rate among people aged 55 to 64 reaches 40%. With the increase of the aging population in the world, the incidence rate is also increasing year by year. [0003] The exact etiology and pathogenesis of osteoarthritis have not yet been fully elucidated. The current treatment methods are mainly aimed at relieving pain, improving function, and improving the quality of life of patients. There is no...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61P19/02A61P29/00A61P19/10A23L1/29A23L33/00
Inventor 吴平安金辉韩涛杨韬
Owner GANSU UNIV OF CHINESE MEDICINE