Concentrated oral solution for treating recurrent oral ulcer by type of fire excess from yin deficiency

A technology for recurrent aphthous ulcers and yin-deficiency fire-prosperity type, which is applied in the field of medicine, can solve the problems of low content of active ingredients, high cost, large side effects, etc., and achieves improved concentration and content of active ingredients, improved quality and effect, and high content of active ingredients. Effect

Inactive Publication Date: 2014-08-06
河南百年康鑫药业有限公司
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above situation, in order to overcome the defects of the prior art, the purpose of the present invention is to provide a concentrated oral liquid for the treatment of recurrent aphthous ulcers caused by yin deficiency and hyperactivity of fire, which can eff

Method used

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  • Concentrated oral solution for treating recurrent oral ulcer by type of fire excess from yin deficiency
  • Concentrated oral solution for treating recurrent oral ulcer by type of fire excess from yin deficiency

Examples

Experimental program
Comparison scheme
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Example Embodiment

[0015] Example 1

[0016] The present invention can also be made from 9kg of Radix Adenophora, 3kg of Rhizoma Coptidis, 7kg of Salvia miltiorrhiza, 6kg of Dendrobium, 25kg of Radix Scrophulariae, 12kg of Scrophulariaceae, 12kg of Anemarrhena, 6kg of Chinese Yam, 10kg of Forsythia and 9kg of Trichosanthes, among which:

[0017] (1) First, rinse the above-mentioned raw materials separately with water, mix, add water and cook twice, add 6 times the weight of the above-mentioned raw materials each time with water, decoc for 1 hour each time, filter, and combine the two filtrates. Concentrated to 50℃, the extract with density of 1.4;

[0018] (2) Let the extract stand for 12 hours, take the supernatant, add 0.5g of honey sucrose mixture and 0.005g of sodium benzoate to every 1ml of supernatant, and boil to dissolve to obtain a solution;

[0019] (3) Add 0.1 times the total weight of the raw material drug to the dissolving solution, stir evenly, refrigerate for 24 hours, and take the supern...

Example Embodiment

[0022] Example 2

[0023] The present invention can also be prepared from Adenophora rhizome 12kg, Rhizoma Coptidis 4kg, Danshen 8kg, Dendrobium 10kg, Habitat 28kg, Scrophulariae 13kg, Anemarrhena 14kg, Chinese Yam 8kg, Forsythia 13kg and Trichosanthes 12kg as raw materials, among which:

[0024] (1) First, rinse the above-mentioned raw materials separately with water, mix, add water to decocate twice, add 8 times the weight of the above-mentioned raw materials each time with water, decoct for 1.5 hours each time, filter, and combine the two filtrates. Concentrated to 60°C, the extract with density of 1.25;

[0025] (2) Let the extract stand for 18 hours, take the supernatant, add 0.015g of glycyrrhizin solution and 0.005g of sodium benzoate to every 1ml of supernatant, and boil to dissolve to obtain a solution;

[0026] (3) Add 0.1 times the total weight of the raw material drug to the dissolving solution, stir evenly, refrigerate for 36 hours, and take the supernatant;

[0027] (4) T...

Example Embodiment

[0029] Example 3

[0030] The present invention can also be prepared from Adenophora rhizome 15kg, Rhizoma Coptidis 6kg, Danshen 9kg, Dendrobium 15kg, Habitat 30kg, Scrophulariaceae 15kg, Anemarrhena 15kg, Yam 10kg, Forsythia 15kg and Trichosanthes 15kg as raw materials, among which:

[0031] (1) First, rinse the above-mentioned raw materials separately with water, mix, add water and cook twice, add 12 times the weight of the above-mentioned raw materials each time with water, cook for 2 hours each time, filter, and combine the two filtrates. Concentrated to 80°C, the extract with a density of 1.1;

[0032] (2) Let the extract stand for 24 hours, take the supernatant, add 0.035g of stevioside solution and 0.005g of sodium benzoate to every 1ml of supernatant, and boil to dissolve to obtain a solution;

[0033] (3) Add 0.1 times the total weight of the raw material drug to the dissolving solution, stir evenly, refrigerate for 48 hours, and take the supernatant;

[0034] (4) The supernat...

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Abstract

The invention relates to a concentrated oral solution for treating recurrent oral ulcer by type of fire excess from yin deficiency, which can be used for effectively solving the problems of poor curative effect, hard healing, long treatment cycle, high side effect, more impurities, low extract utilization, low content of effective components, poor administration effect and inconvenience in carrying. The oral solution is prepared from adenophora tetraphylla, coptis chinensis, salviae miltiorrhizae, dendrobium, unprocessed rehmannia root, radix scrophulariae, rhizoma anemarrhenae, yam, fructus forsythiae and radices trichosanthis by the following steps: washing the components, mixing, decocting twice, filtering, concentrating, and combining the filtrates; concentrating to obtain extract, standing, taking supernate, and adding a honey and cane glucose mixture or a glycyrrhizin solution or a stevioside solution; adding sodium benzoate, boiling to dissolve; adding water, uniformly stirring, refrigerating and centrifugally separating the supernate; and performing ultrafiltration on the supernate by an ultrafiltration membrane, encapsulating the ultrafiltrate, and sterilizing. The concentrated oral solution is small in side effects, increased in concentration and content of effective ingredients, small in dosage and convenient to take and carry, and is suitable for patients who cannot decoct decoction or are difficult to take medicines.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a concentrated oral liquid for treating recurrent aphthous ulcers of yin deficiency and hyperactivity of fire. Background technique [0002] Recurrent aphthous ulcers, also known as aphthous stomatitis, are small and painful ulcers on the oral mucosa, with periodic, recurrent, and self-limiting characteristics, and the ulcers have obvious burning pain. The traditional Chinese medical science thinks that its etiology and pathogenesis are weakness of the spleen and stomach, asthenic fire and inflammation. The fiery evil invades the viscera and is fumigated in the mouth. Improper diet, overeating fat, sweet and thick taste, transforms heat and dampness. Excessive thinking, emotional discomfort. The water-cold air is superior, forcing the external inflammation of the heart-fire and the imbalance of Chong and Ren can lead to this disease. [0003] Most of the ulcers are scattered and distr...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61P1/02
Inventor 郭鑫慧蔡俊安王粉
Owner 河南百年康鑫药业有限公司
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