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Medicine composition for treating calculus and preparation method and application thereof

A technology of composition and medicine, which is applied in the field of pharmaceutical composition for treating stones and its preparation and application, can solve the problems of unsatisfactory cure rate and effective rate of western medicine, unsatisfactory long-term effect, and large side effects of human body, etc. Achieve the effect of reducing tissue oxalic acid content, protecting tissues and organs, and clear drug effect

Inactive Publication Date: 2014-12-10
SICHUAN SAINTHOOD BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, laser lithotripsy, pneumatic ballistic lithotripsy, minimally invasive laparoscopic cholecystectomy, skin nephrolithotripsy, etc. It has special features and stable curative effect, but its equipment is expensive, the technical requirements are high, and the long-term effect is not ideal (high recurrence rate); there are also reports that drugs are used to expel stones, but Western medicine is still not enough in terms of cure rate and effective rate. Satisfactory, and long-term use of western medicine for stone removal will cause relatively large side effects on the human body

Method used

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  • Medicine composition for treating calculus and preparation method and application thereof
  • Medicine composition for treating calculus and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Slice or cut 15kg of desmodium, 10kg of sea ginseng, 15kg of rhubarb, 6kg of turmeric, 25kg of plantain seed, 5kg of licorice, 20kg of Kochia scoparia, 20kg of fennel, 5kg of fennel, wash, soak in 3 times the amount of 75% ethanol 4 hours, then add 5 times the amount of 75% ethanol, heat and boil for 2 hours, filter to get the filtrate, add 6 times the amount of 75% ethanol to the filter residue, heat and boil for 1.5 hours, filter and get the filtrate, combine the two times of filtrate and concentrate under reduced pressure (density is 0.24- 0.46g / ml), spray drying to obtain dry extract powder, the dry powder yield is 24.2%.

[0040] Take the extract powder and add appropriate amount of starch to prepare granules.

Embodiment 2

[0042] Slice or cut 5kg Desmodium, 5kg Rhizoma Rhizoma, 10kg Rhubarb, 2kg Turmeric, 15kg Plantago, 5kg Licorice, 10kg Kochia, 10kg Qumai, 2kg Cumin, wash and soak in 3 times the amount of 75% ethanol 4 hours, then add 5 times the amount of 75% ethanol, heat and boil for 2 hours, filter to get the filtrate, add 6 times the amount of 75% ethanol to the filter residue, heat and boil for 1.5 hours, filter and get the filtrate, combine the two times of filtrate and concentrate under reduced pressure (density 0.24-0.46 g / ml), spray drying to obtain dry extract powder, the dry powder yield is 22.3%.

[0043] Take the extract powder, add appropriate amount of starch and dextrin, granulate and compress into tablets to obtain tablets.

Embodiment 3

[0045] Slice or cut 20kg of desmodium, 20kg of sea ginseng, 30kg of rhubarb, 10kg of turmeric, 35kg of psyllium, 10kg of licorice, 30kg of Kochia scoparia, 35kg of fennel, 10kg of cumin, wash and soak in 3 times the amount of 75% ethanol 4 hours, then add 5 times the amount of 75% ethanol, heat and boil for 2 hours, filter to get the filtrate, add 6 times the amount of 75% ethanol to the filter residue, heat and boil for 1.5 hours, filter and get the filtrate, combine the two times of filtrate and concentrate under reduced pressure (density 0.24-0.46 g / ml), spray drying to obtain dry extract powder, the dry powder yield is 25.1%.

[0046] Take the extract powder, add appropriate amount of microcrystalline cellulose, mix, dry, pack into capsules to obtain capsules, and each capsule contains 0.5g of the extract powder.

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Abstract

The invention provides a medicine composition for treating calculus. The medicine composition consists of the following components in parts by weight: 5-20 parts of christina loosestrife herb, 5-20 parts of lygodium japonicum, 10-30 parts of rheum officinale, 2-10 parts of turmeric, 15-35 parts of semen plantaginis, 5-10 parts of liquorice, 10-30 parts of fructus kochiae, 10-35 parts of dianthus superbus and 2-10 parts of fennel. After nine medicinal materials such as christina loosestrife herb are combined, under the condition that the dosage is equal to or lower than that of a single medicine, the calculus discharging effect is obviously better than that of the single medicine, so that the nine combined medicines achieve a synergistic effect; test shows that the medicine composition has the effects of reducing the quantity of tissue calculus, reducing the content of tissue oxalic acid, suppressing calcium oxalate crystallization formation and stacking and enabling crystals to be loosened, minimized, smashed and easily discharged along with urine, and can further effectively improve symptoms, such as pain in the kidney, the bladder and the urethral canal part and hematuresis, which are caused by lithiasis, reduce injury to tissue organs and protect the tissue organs.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating gallstones, a preparation method and application thereof. Background technique [0002] Stone disease is a disease caused by the accumulation of calcium salts or lipids caused by abnormal mineralization of the human body. In today's rapid economic development, people's pace of life is accelerated, overloaded work, life is irregular, diet structure changes, and the incidence of stone disease is on the rise. The phenomenon of rejuvenation of the onset population is also becoming more and more obvious. The high incidence population is between 25 and 50 years old, and women are especially prone to it. [0003] Calculus is a kind of common frequently-occurring disease, and its kind has kidney calculus, gallstone, bile duct calculus, bladder calculus, urinary tract calculus etc., suffering from calculus disease can affect production, life and work, needs to do operation when serious, even en...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P1/16A61P13/04
Inventor 郭小雪严晓玲钟莉沙张弘钟雨禅黄泽祥
Owner SICHUAN SAINTHOOD BIOTECH
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