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Method for determining dissolution rate of cefaclor capsules

A technology of Clorox capsule and determination method, which is applied in the field of medicine, and can solve problems such as affecting product bioavailability, insufficient drug efficacy, and difficulty in cefaclor

Inactive Publication Date: 2014-12-10
SICHUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Cefaclor is poorly soluble in water, resulting in slow dissolution in the organism, which ultimately affects the bioavailability of the product
At present, there is no test method for the dissolution rate of cefaclor capsules in intestinal fluid, and there are insufficient clinical efficacy tests

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] A method for measuring the dissolution rate of cefaclor capsules, comprising the following steps:

[0015] (3) Determine the absorption wavelength of cefaclor capsules: take an appropriate amount of the contents of cefaclor capsules to be tested and cefaclor standard substance, and prepare a solution of 20 micrograms / ml with a phosphate buffer solution with a pH of 6.8. Scan within the wavelength range of -400nm to determine the wavelength of the maximum absorption;

[0016] (4) Determination of dissolution rate: After turning cefaclor in 1000ml of 0.1mol / L hydrochloric acid solution at an appropriate speed for 2 hours, discard the supernatant, rinse the solid with water, and then add a phosphate buffer solution with a pH of 6.8 1000ml, take the solution 10ml and filter at 30, 32, 40, 45, and 50min respectively after being treated at the same speed as before, and accurately measure 5ml of the filtrate, and place it in a 50ml volumetric flask; dilute it with a phos...

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PUM

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Abstract

The invention discloses a method for determining the dissolution rate of cefaclor capsules. Artificial intestinal juice which is phosphate buffer solution with the pH value of 6.8 is simulated and is used as solvent for determining the dissolution rate, and the method has important significance on testing the clinical utility.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a method for measuring the dissolution rate of cefaclor capsules. Background technique [0002] Cefaclor, whose chemical name is (6R ,7R)-7-[(R )-2-amino-2-phenylacetamido]-3-chloro-8-oxo-5-thia-1-aza Bicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate, cefaclor is a semi-synthetic second-generation β-lactam antibiotic with strong antibacterial activity against Gram-positive bacteria, With high efficiency, broad spectrum and good chemical stability, it is one of the important drugs for clinical treatment of bacterial infections. [0003] Cefaclor is poorly soluble in water, resulting in slow dissolution in the organism, which ultimately affects the bioavailability of the product. At present, there is no method for measuring the dissolution rate of cefaclor capsules in intestinal fluid, and there are insufficient clinical efficacy tests. Contents of the invention [0004] The techni...

Claims

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Application Information

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IPC IPC(8): G01N21/31
Inventor 王强张静文刘萍
Owner SICHUAN PHARMA