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Paclitaxel composition and preparation method thereof

A technology of paclitaxel and its composition, which is applied in the field of medicine, can solve the problems of paclitaxel oral preparations and low bioavailability, and achieve the effects of improving oral bioavailability, simple preparation method, and low cost

Inactive Publication Date: 2014-12-24
长治市武理工工程技术研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, due to reasons such as low oral bioavailability, no paclitaxel oral preparations have been marketed yet.

Method used

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  • Paclitaxel composition and preparation method thereof
  • Paclitaxel composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Dissolve 0.1g of L-carnosine in 100mL of ethanol, then add 0.1g of sodium stearyl fumarate to obtain an auxiliary material dispersion; dissolve 0.1g of paclitaxel with 50mL of ethanol to obtain a drug dispersion; mix the auxiliary material dispersion and the drug dispersion Mix evenly, recover ethanol under vacuum at 40°C, and dry at 40°C for 6 hours to obtain the product.

Embodiment 2

[0014] Dissolve 0.1g of L-carnosine in 100mL of ethanol, then add 0.1g of sodium stearyl fumarate to obtain an auxiliary material dispersion; dissolve 0.1g of paclitaxel with 20mL of ethanol to obtain a drug dispersion; mix the auxiliary material dispersion and the drug dispersion Mix evenly, recover ethanol under vacuum at 40°C, and freeze-dry to obtain the obtained product.

Embodiment 3

[0016] Dissolve 0.1g of L-carnosine in 200mL of ethanol, then add 0.1g of sodium stearyl fumarate to obtain an auxiliary material dispersion; dissolve 0.1g of paclitaxel with 100mL of ethanol to obtain a drug dispersion; mix the auxiliary material dispersion and the drug dispersion Mix evenly, recover ethanol under vacuum at 30°C, and freeze-dry to obtain the obtained product.

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Abstract

The invention provides a paclitaxel composition with a high oral bioavailability and a preparation method of the paclitaxel composition. The paclitaxel composition is characterized by comprising paclitaxel, sodium stearyl fumarate and L-carnosine, wherein the mass ratio of paclitaxel to sodium stearyl fumarate to L-carnosine is preferably 1:1:1. The preparation method of the paclitaxel composition comprises the following steps: dissolving L-carnosine with ethanol, adding sodium stearyl fumarate to the solution to obtain accessory dispersion liquid, dissolving paclitaxel with ethanol to obtain medicine dispersion liquid, uniformly mixing the accessory dispersion liquid with the medicine dispersion liquid, recycling ethanol, and drying the solution to obtain the composition.

Description

technical field [0001] The invention relates to a paclitaxel composition and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Paclitaxel has a good effect in treating tumors, but injection administration not only has poor patient compliance and high cost, but also easily causes serious adverse reactions. Oral administration of paclitaxel has the advantages of convenience, low cost, and good safety, and has always been a research hotspot. But so far, due to reasons such as low oral bioavailability, no paclitaxel oral preparations have been marketed. Contents of the invention [0003] The object of the present invention is to provide a paclitaxel composition with high oral bioavailability and a preparation method thereof. [0004] For the purpose of the above invention, the present invention provides the following technical solutions: [0005] The paclitaxel composition of the present invention is characterized in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/337A61K47/18A61K47/12A61P35/00
Inventor 罗瑞雪
Owner 长治市武理工工程技术研究院
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