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Polymer drug-loaded materials for microvascular decompression surgery

A microvascular and polymer technology, applied in the field of polymer drug-loaded materials used in microvascular decompression surgery, can solve the problems of surrounding tissue adhesion, difficult to control aseptic meningitis, material displacement, etc., to reduce the recurrence rate and Complications, good brain histocompatibility, and the effect of improving surgical outcomes

Inactive Publication Date: 2016-08-10
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Based on a large amount of surgical experience and related literature analysis, the inventor believes that the materials currently used have the following disadvantages: ① short fibers and poor elasticity, resulting in insufficient decompression; ② easily deformed and hardened, resulting in material displacement, shedding, and recurrence of symptoms ; ③Adhesion with the surrounding tissue, forming granuloma, resulting in re-compression, and recurrence of symptoms; ④ Individuals may still have uncontrollable aseptic meningitis, resulting in the need for reoperation to remove the implant material

Method used

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  • Polymer drug-loaded materials for microvascular decompression surgery
  • Polymer drug-loaded materials for microvascular decompression surgery
  • Polymer drug-loaded materials for microvascular decompression surgery

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Embodiment 1. Preparation of drug-loaded polymer PVA material

[0026] 1. Preparation of PVA decompression material

[0027] Weigh polyvinyl alcohol (PVA) and dextran (DEX) powders into a 50 mL Erlenmeyer flask with a stopper, add an appropriate amount of distilled water, and heat with magnetic stirring to a constant temperature of 80 °C until the polymer is swollen and dissolved to obtain a concentration of 5 %~15% PVA aqueous solution. The PVA solution was sucked into a 5 mL glass syringe equipped with a 9# stainless steel needle, and the tip of the needle was ground flat as a spray needle, with an outer diameter of 1 mm and an inner diameter of 0.7 mm. The injection needle is connected to the positive pole of the high-voltage power supply, the collection device is connected to the negative pole of the power supply, and the injection voltage is set at 5 kV to 15 kV. The flow rate of the PVA solution was controlled by a syringe pump, the flow rate was 0.5 mL / h, and t...

Embodiment 2

[0034] Example 2. Biocompatibility and its promoting effect on Schwann cell growth

[0035] Co-cultivation of drug-loaded polymer materials and Schwann cells: Take out the bilateral sciatic nerves of 3-day-old Wistar rats under sterile conditions, cut them into paste and put them into centrifuge tubes, add 0.125% trypsin + 0.03% IV Type collagenase, digest for 30-40min; centrifuge at 1500r / min for 5min; suspend the pellet with DMEM10%FCS medium, inoculate into culture dish, 37℃, volume fraction 5%CO 2 Incubate in a cell culture incubator. After 24 hours of culture, cytarabine with a final concentration of 10-5mmol / L was added to inhibit fibroblasts and glial cells, and the purity of Schwann cells identified by rabbit anti-S-100 polyclonal antibody was above 95%. 5-7 days after culture, press 1×10 6 Each / L concentration was passaged to a 0.5cm×0.5cm drug-loaded polymer material petri dish. On the seventh day after inoculation, the growth of Schwann cells in the experimental ...

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Abstract

The invention discloses a polymer drug-loaded material used in microvascular decompression surgery, including PVA and dextran, and as a preferred solution, also includes nerve growth factor. The aqueous solution of PVA and dextran is electrostatically spun to prepare a PVA fiber material, and the obtained PVA fiber material is heated and cross-linked and then cooled to obtain a PVA decompression material. The present invention has developed a new type of drug-loaded polymer decompression material suitable for MVD surgery, which has good brain tissue compatibility, elasticity, biodegradation resistance and cerebrospinal fluid adaptability, and has the effect of promoting the repair of pathological nerve myelin, further reducing The recurrence rate and complications are improved, and the curative effect of surgery is improved.

Description

technical field [0001] The invention relates to a polymer drug-loaded material used in microvascular decompression surgery for cranial nerve diseases and a preparation method thereof. Background technique [0002] Trigeminal Neuralgia (TN) and Hemifacial Spasm (HFS) are a group of functional diseases caused by cranial nerve demyelination caused by long-term compression of blood vessels, which seriously affect the physical and mental health of patients. Microvascular Decompression (MVD) is currently the only surgical treatment for this etiology. Among them, the decompression material used to open the responsible blood vessel during operation is an important factor affecting the curative effect of MVD operation. At present, the decompression materials used in MVD surgery at home and abroad are not uniform. Most of the literature reports use Teflon, Ivalon sponge (polyvinyl alcohol foam), Gore-Tex biological patch (expanded polytetrafluoroethylene), dacron cotton or autologous...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/045A61L31/04A61L31/16D01F8/10D01F8/18
Inventor 尚寒冰赵卫国
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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