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A method for preparing sea-tangle antihypertensive products coupled with step-by-step extraction and biotransformation

A technology for biotransformation and lowering blood pressure, which is applied in the preparation methods of peptides, chemical instruments and methods, and medical preparations containing active ingredients, etc. Complex problems, to achieve the effect of improving high-value utilization, shortening extraction time, and improving extraction efficiency

Active Publication Date: 2017-01-11
FUZHOU HAILIN FOODSTUFF
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent basically realizes the comprehensive utilization of kelp, and obtains the mixed crude extract of kelp's nutritional components, but has not yet obtained a specific single component, and has not been able to study and utilize the specific effects of nutrient components. The economic value is not high enough to Realize the high-value utilization of kelp, and the steps are complicated and consume a lot of energy

Method used

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  • A method for preparing sea-tangle antihypertensive products coupled with step-by-step extraction and biotransformation
  • A method for preparing sea-tangle antihypertensive products coupled with step-by-step extraction and biotransformation
  • A method for preparing sea-tangle antihypertensive products coupled with step-by-step extraction and biotransformation

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Experimental program
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Embodiment 1

[0026] A method for preparing kelp hypotensive products by step-by-step extraction and biotransformation coupling comprises the following steps:

[0027] 1) Raw material pretreatment: fresh kelp or kelp scraps are cleaned and impurity removed, dried at low temperature at 60℃ to constant weight, pulverized into 80 mesh powder for use.

[0028] 2) Alcohol extraction of mannitol: the powder in step 1) and 95wt.% ethanol are subjected to cyclic ultrasonic-assisted extraction with a solid-liquid ratio of 1:30, time 55min, temperature 50°C, vacuum filtration, and the filter residue is vacuum-dried for later use After the filtrate is concentrated, suction filtration while hot, crystallize at 0°C, filter and dry to obtain the kelp mannitol product;

[0029] 3) Acid-extracted algin and fucoidan: mix the filter residue in 2) with 0.1 mol·L -1 The hydrochloric acid solution was subjected to cyclic ultrasonic-assisted extraction with a solid-to-liquid ratio of 1: 50, the time was 45 min,...

Embodiment 2

[0059] A method for preparing kelp hypotensive products by step-by-step extraction and biotransformation coupling comprises the following steps:

[0060] 1) Raw material pretreatment: fresh kelp or kelp scraps are cleaned and impurity removed, dried at 60℃ to constant weight, pulverized into 100-mesh powder for use.

[0061] 2) Alcohol extraction of mannitol: the powder in step 1) and 95wt.% ethanol are extracted with cyclic ultrasonic assistance at a solid-liquid ratio of 1:25, time is 60 minutes, temperature is 50°C, suction filtration under reduced pressure, and the filter residue is vacuum-dried for later use After the filtrate is concentrated, suction filtration while hot, crystallize at 0°C, filter and dry to obtain the kelp mannitol product;

[0062] 3) Acid-extracted algin and fucoidan: mix the filter residue in 2) with 0.1 mol·L -1 The hydrochloric acid solution was subjected to cyclic ultrasonic-assisted extraction with a solid-liquid ratio of 1:35, the time was 50 ...

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Abstract

The invention relates to a health care product for assisting blood pressure reduction, provides a method for preparing a health care seaweed product for assisting blood pressure reduction via step-by-step extraction and bioconversion coupling, and belongs to the field of deep processing of ocean foods. The method is carried out by taking high-quality seaweeds as raw materials via an ultrasonic circulation step-by-step extraction process and a bioconversion coupling preparation technology. The preparation method sequentially comprises the following steps: carrying out pretreatment of raw materials, alcohol extraction of mannitol, acid extraction and alcohol precipitation of sodium alginate and fucoidan, bioconversion and ultrafiltration so as to obtain physiological active components for reducing blood pressure; and scientifically blending the active components. According to the method, a large quantity of seafood seaweeds in China are deeply processed and comprehensively utilized so as to obtain five products, namely mannitol, sodium alginate, fucoidan, seaweed dietary fibers and seaweed antihypertensive peptides; and the five products are scientifically blended so as to develop a series of novel functional seaweed products for reducing blood pressure reduction, wherein the series of functional seaweed products have obvious functions of assisting blood pressure reduction. The ACE inhibitory activity IC50 of the seaweed product is within 0.68mg / g to 1.15mg / g, so that the blood pressure of an SHR (Spontaneously Hypertensive Rat) can be obviously lowered (-12.4 mmHg to -17.5mmHg).

Description

technical field [0001] The invention belongs to the field of deep and deep processing of marine food, in particular to a method for preparing an auxiliary blood pressure-lowering health-care kelp product by step-by-step extraction and biotransformation coupling. Background technique [0002] Hypertension is an important risk factor for cardiovascular and cerebrovascular diseases, and it has become a serious international public health problem. However, most of the blood pressure lowering drugs currently on the market are chemically synthesized drugs. discomfort. Therefore, it is very important to develop a food-based hypotensive product with high safety, small side effects and easy absorption. [0003] Kelp is rich in nutrients and has many functions. It is known as the "Crown of Alkaline Plants" and has high economic value. It is a valuable raw material for the pharmaceutical industry to reduce blood lipids and fight cancer. According to data records, eating kelp to lowe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L29/30A23L33/18A23L33/21C07C29/76C07C31/26C12P21/06C07K1/34C08B37/04A61K38/00A61P9/12A61K31/047A61K31/734A23L33/125A23L33/20
CPCA23V2002/00C07C29/76C08B37/0084A23V2200/326A23V2250/64A23V2250/502A23V2250/5116A23V2250/55C07C31/26
Inventor 陈继承王洁李艳杰陈丽娇陈艺晖
Owner FUZHOU HAILIN FOODSTUFF
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