Magnetic-fluorescent difunctional graphene oxide nanocomposite and preparation method thereof

A technology of nanocomposite materials and magnetic nanoparticles, which is applied in the direction of luminescent materials, chemical instruments and methods, nanotechnology, etc., can solve the problems that the biological safety of cadmium-containing quantum dots has not been fundamentally solved, and the decomposition cannot be completely eliminated. The effect of big medical application value

Active Publication Date: 2015-01-07
深圳特新界面科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the preparation, structure and performance detection of cadmium-containing quantum dots are very mature, and a large number of studies have shown that the stability and safety of Cd-containing quantum dots can be greatly improved by using surface modification

Method used

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  • Magnetic-fluorescent difunctional graphene oxide nanocomposite and preparation method thereof
  • Magnetic-fluorescent difunctional graphene oxide nanocomposite and preparation method thereof
  • Magnetic-fluorescent difunctional graphene oxide nanocomposite and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Preparation of graphene oxide

[0032] Add 2g graphite powder to 25g concentrated H 2 SO 4 , 2.5g K 2 S 2 o 8 and 2.5g P 2 o 5 In the mixed solution, react at 80°C for 3h. Then add 500ml of water to dilute, and filter and wash to remove excess acid. The resulting pre-product was dried overnight at room temperature, and then the pre-oxidized graphite was added to 100 ml of concentrated H 2 SO 4 , gradually added 13g KMnO under the protection of ice-water bath 4 , the mixture was stirred and reacted at 35°C for 30 minutes, then reacted at 85°C for 2 hours, then diluted with water, allowed to boil for 30 minutes, and stirred for 1 hour, then added 500ml of water, 20ml and 30% H 2 o 2 The solution precipitated on standing. After the mixture was filtered, it was washed 5 times with 1:10 dilute hydrochloric acid, and then washed with water until neutral. Finally, the obtained product was dialyzed for one week to purify and remove the remaining metal ions, ...

Embodiment 2

[0042] (1) Preparation of graphene oxide

[0043] Add 2g graphite powder to 25g concentrated H 2 SO 4 , 2.5g K 2 S 2 o 8 and 2.5g P 2 o 5 In the mixed solution, react at 70°C for 5h. Then add 500ml of water to dilute, and filter and wash to remove excess acid. The resulting pre-product was dried overnight at room temperature, and then the pre-oxidized graphite was added to 150 ml of concentrated H 2 SO 4 20g KMnO was gradually added under the protection of an ice-water bath 4 , the mixture was stirred and reacted at 30°C for 30 minutes, then reacted at 85°C for 2 hours, then diluted with water, allowed to boil for 30 minutes, and stirred for 1 hour, then added 500ml of water, 20ml of water and 30% H 2 o 2 The solution precipitated on standing. After the mixture was filtered, it was washed 5 times with 1:10 dilute hydrochloric acid, and then washed with water until neutral. Finally, the obtained product was dialyzed for one week to purify and remove the remainin...

Embodiment 3

[0053] (1) Preparation of graphene oxide

[0054] Add 2g graphite powder to 25g concentrated H 2 SO 4 , 2.5g K 2 S 2 o 8 and 2.5g P 2 o 5 In the mixed solution, react at 80°C for 3h. Then add 500ml of water to dilute, and filter and wash to remove excess acid. The resulting pre-product was dried overnight at room temperature, and then the pre-oxidized graphite was added to 100 ml of concentrated H 2 SO 4 , gradually added 13g KMnO under the protection of ice-water bath 4 , the mixture was stirred and reacted at 35°C for 30 minutes, then reacted at 85°C for 2 hours, then diluted with water, allowed to boil for 30 minutes, and stirred for 1 hour, then added 500ml of water, 20ml and 30% H 2 o 2 The solution precipitated on standing. After the mixture was filtered, it was washed 5 times with 1:10 dilute hydrochloric acid, and then washed with water until neutral. Finally, the obtained product was dialyzed for one week to purify and remove the remaining metal ions, ...

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Abstract

The invention relates to a magnetic-fluorescent integrated multifunctional graphene oxide nanocomposite and a preparation method thereof and belongs to the technical field of the inorganic nano materials. The preparation method comprises the following steps: preparing ZnO quantum dots and Fe3O4 nanoparticles having a mesoporous structure, respectively, and then covering the two types of nanoparticles with a SiO2 shell layer and performing amination on the nanoparticles; grafting the aminated nanoparticles on the surface of the graphene oxide treated by surface carboxylation previously in a covalent crosslinking way, and finally obtaining a magnetic-fluorescent difunctional graphene oxide nanocomposite. The graphene oxide nanocomposite prepared by use of the preparation method has obvious magnetic properties; due to extremely large specific surface area of the graphene oxide, the graphene oxide nanocomposite has bright application prospect in the aspect of the drug targeting transport carriers; besides, due to excellent fluorescent properties, the transport path of the graphene oxide nanocomposite when used as a drug carrier can be traced.

Description

technical field [0001] The invention belongs to the technical field of inorganic nanometer materials and biomedicine, and in particular relates to a magnetic fluorescent bifunctional graphene oxide nanocomposite material which can be used as a targeting drug carrier and a preparation method thereof. Background technique [0002] Graphene derivatives that are widely used in the biomedical field are mainly functionalized graphene oxide. In recent years, metal nanoparticles and magnetic nanoparticles have been loaded on the surface of graphene oxide to prepare composite materials, and their applications in materials, chemistry, Research on applications in fields such as biomedicine is developing rapidly. At present, the existing domestic and foreign applications of it in biomedicine are mainly used in bioimaging, biodetection, tumor treatment and drug carrier, and these studies have achieved gratifying results. Research on graphene oxide as a drug carrier: First, graphene has ...

Claims

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Application Information

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IPC IPC(8): C09K11/54
CPCB82Y20/00B82Y30/00B82Y40/00C09K11/025C09K11/54C09K11/65
Inventor 张艳华黄磊肖巍邓莹于弘陈慧刘煌孙兰兰
Owner 深圳特新界面科技有限公司
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