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Method of detecting tuberculosis

A tuberculosis and anti-tuberculosis technology, applied in the direction of chemical instruments and methods, biochemical equipment and methods, measuring devices, etc., can solve the problem of inaccurate distinction

Inactive Publication Date: 2015-01-07
PEAS INSTITUT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0032] The immune system effectively distinguishes self from non-self, yet emergence of autoimmune disease suggests this distinction may be inaccurate

Method used

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  • Method of detecting tuberculosis
  • Method of detecting tuberculosis
  • Method of detecting tuberculosis

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Embodiment Construction

[0062] We have developed specific antibodies against mycobacterial species (PPD, BCG and MTB) in vitro. The antibody is fixed to the surface plasmon resonance (SPR) system of the biosensor, and can recognize particles in the serum / plasma of TB patients with high sensitivity and specificity.

[0063] This discovery can be used as a basis for the development of diagnostic tests to

[0064] -Diagnose TB infection in patients

[0065] -Distinguish between different Mycobacterium tuberculosis infections (Mycobacterium tuberculosis, Mycobacterium bovis, non-tuberculous mycobacterium infection, etc.)

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Abstract

The present invention relates to a method for determining whether an individual has an active tuberculosis infection, a latent tuberculosis infection or is vaccinated against a tuberculosis infection or being healthy. The method comprises contacting a body fluid sample from an individual with an antibody having specificity for a Mycobacterium tuberculosis (Mtb) protein mimicking a human protein and studying the interaction between the protein in the sample and the antibody. High levels of proteins interacting with the antibody are indicative of an active Mtb infection and low levels of proteins interacting with the antibody are indicative of a latent Mtb infection. No levels of proteins interacting with the antibody are indicative of a vaccinated or healthy individual. The present invention also relates to a method determining whether the individual has a tuberculosis infection and to a method for detecting the potency of a vaccination against tuberculosis by contacting a sample from the individual with an antibody having a specificity for the Mtb or the BCG vaccine respectively and studying the interaction between the sample and the specific antibody.

Description

Technical field [0001] The present invention relates to a method for detecting tuberculosis infection in an individual and a method for detecting whether the individual has been vaccinated against tuberculosis vaccine. Background of the invention [0002] Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) 1,2 . At present, it is one of the main causes of death from infectious diseases in the world, and therefore poses an important public health problem 2 . Although the number of TB cases has been declining since 2006, an estimated 3 million deaths are reported each year among 8 to 10 million infected people 1,3 . About 2 billion people are latently infected with Mtb, and according to WHO, it causes 9.8 million new cases and approximately 1.8 million deaths worldwide each year 1,3 . This problem is compounded by the emergence of multi-drug-resistant (MDR) and extensively drug-resistant (XDR) strains 2,4 . The most common method used to diagnos...

Claims

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Application Information

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IPC IPC(8): G01N33/569C12Q1/04C07K16/12
CPCC12Q1/04C07K16/1289G01N33/5695
Inventor F·纳耶里
Owner PEAS INSTITUT
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