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Two-dimensional fluid separation with controlled pressure

A fluid and pressure technology, applied in the direction of solid adsorbent liquid separation, material separation, separation method, etc.

Active Publication Date: 2015-01-14
AGILENT TECH INC
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  • Two-dimensional fluid separation with controlled pressure
  • Two-dimensional fluid separation with controlled pressure
  • Two-dimensional fluid separation with controlled pressure

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Embodiment Construction

[0077] According to an exemplary embodiment of the present invention, a two-dimensional liquid chromatography (2D-LC) system with constant pressure mode is provided for accurate and reliable two-dimensional separation. A dedicated control mode is provided for tandem LCs to support fast separations (less than 30 seconds).

[0078] In 2D-LC, there is often a need to both execute the elution gradient very quickly and deliver the flow at the target component gradient accurately and precisely. The term "UHPLC" describes systems with higher demands in terms of speed and pressure. With increasing interest in increasing peak capacity (the total number of peaks that can be resolved in a single experiment), several parameters were optimized. These include smaller dimensions of packing materials, smaller separation columns, faster linear velocities of solutes during separation, faster component gradients, longer separation beds, and more. Putting this all together leads to the fact tha...

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Abstract

A sample separation apparatus (200) for separating a fluidic sample, the sample separation apparatus (200) comprising a first separation unit (204) for separating the fluidic sample, a first fluid drive (202) configured for conducting the fluidic sample to be separated through the first separation unit (204), a second separation unit (208), arranged downstream of the first separation unit (204), for further separating the fluidic sample after treatment by the first separation unit (204), a second fluid drive (206) configured for at least partially conducting the fluidic sample, after treatment by the first separation unit (204), through the second separation unit (208), and a fluidic valve (218) having fluidic interfaces (222, 224, 226, 228) fluidically coupled to the first fluid drive (202) and the second fluid drive (206) and being switchable for performing the separation of the fluidic sample, wherein the sample separation apparatus (200) is configured for adjusting a pressure at a predefined position to a predefined value, wherein the predefined position is in a fluidic path between an outlet (270) of the first separation unit (204) and an inlet (272) of the second separation unit (208) or in fluid communication with this fluidic path.

Description

technical field [0001] The present invention relates to sample separation systems. Background technique [0002] In liquid chromatography, a fluid sample and eluent (liquid mobile phase) are pumped through conduits and a column where separation of the sample components occurs. The column may comprise materials capable of separating the different components of the fluid analyte. This packing material (so-called particles, which may include silica gel) can be filled into a cylindrical tube, which can be connected to other elements, eg samplers, detectors, via conduits. [0003] The composition of the mobile phase can be adjusted by composing the mobile phase from different fluid components with various contributions, the so-called gradient mode. HPLC systems are often operated in a gradient mode in which, for example, the organic content is ramped over time for reversed phase chromatography, or the salt content is ramped over time for ion exchange chromatography. Especially...

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Application Information

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IPC IPC(8): G01N30/32G01N30/46
CPCG01N30/32G01N30/6095G01N2030/322G01N30/465G01N2030/328G01N30/463G01N30/34B01D15/18G01N27/44704G01N30/72
Inventor 克劳斯·威特康斯坦丁·乔伊海特
Owner AGILENT TECH INC
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