2-(4-bromine benzyl) pyrrolidine preparation method
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- 湖南华腾制药有限公司
- Publication Date
- 2015-01-21
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention relates to a novel preparation method of a pharmaceutical intermediate, in particular to a preparation method of 2-(4-bromobenzyl)pyrrolidine. technical background
[0002] Compound 2-(4-bromobenzyl)pyrrolidine, the English name is 2-(4-bromobenzyl)pyrrolidine, and its structural formula is:
[0003]
[0004] The compound 2-(4-bromobenzyl)pyrrolidine and related derivatives are widely used in medicinal chemistry and organic synthesis. The synthesis of 2-(4-bromobenzyl)pyrrolidine is relatively difficult at present. Therefore, it is necessary to develop a synthetic method with easy-to-obtain raw materials, convenient operation, easy-to-control reaction and suitable overall yield. Contents of the invention
[0005] The invention discloses a method for preparing 2-(4-bromobenzyl)pyrrolidine, which uses p-bromophenylacetic acid as a starting material, and undergoes esterification, coupling, ring opening, ring closing and reduction to o...