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Preparation method of liver benefiting tablet containing nepal dock root and day lily and application of liver benefiting tablet to preparation of drug for restraining multiplication of leukemia cell L1210 cell

A technology of Huang Xuan benefiting the liver and Hemerocallis, which can be used in drug combinations, medical preparations containing active ingredients, anti-tumor drugs, etc. It can solve the problems of large dosage, backwardness, and many impurities in patients, and achieve the effect of reducing the dosage.

Inactive Publication Date: 2015-01-28
SHANDONG ZHONGDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no Huangxuan Yigan powder that uses CO in the extraction and preparation. 2 There are reports of supercritical extraction, microwave technology and macroporous resin adsorption technology for extraction, while the method of directly powdering traditional Chinese medicine is rough, backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product. application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 291g of rhubarb, 103g of daylilies, 92g of Senecio, 92g of kiwi fruit, 92g of red soil Poria, 62g of wild rose, 62g of watercress, 62g of Saoyanggu, 62g of southern Schisandra: take wild rose, Saoyanggu and southern Schisandra, and grind them into fine powder, added to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained for later use; the extracted wild rose, Sao Yanggu, Schisandra chinensis residues and other six-flavor medicinal materials are crushed, and 5L of 60% ethanol is added to microwave extraction Microwave extraction is carried out in the device, extraction power is 700W, extraction is 2 times, 8 minutes each time, the extracts are combined, concentrated, added to D101 macrop...

Embodiment 2

[0034] Take 291g of rhubarb, 103g of daylilies, 92g of Senecio, 92g of kiwi fruit, 92g of red soil Poria, 62g of wild rose, 62g of watercress, 62g of Saoyanggu, 62g of southern Schisandra: take wild rose, Saoyanggu and southern Schisandra, and grind them into fine powder, added to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 130min, and the supercritical extract is obtained for later use; the extracted wild rose, Sao Yanggu, Schisandra chinensis residues and other six-flavored medicinal materials are crushed, added 5L of 60% ethanol, and put into microwave extraction Microwave extraction is carried out in the device, the extraction power is 600W, extraction is 2 times, 8 minutes each time, the extracts are combined, concentrated, added to t...

Embodiment 3

[0037] Take 291g of rhubarb, 103g of daylilies, 92g of Senecio, 92g of kiwi fruit, 92g of red soil Poria, 62g of wild rose, 62g of watercress, 62g of Saoyanggu, 62g of southern Schisandra: take wild rose, Saoyanggu and southern Schisandra, and grind them into fine powder, added to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 20MPa, the temperature is 30°C, and CO 2The flow rate is 1ml / g crude drug·min, the extraction time is 170min, and the supercritical extract is obtained for use; the extracted wild rose, Sao Yanggu, Schisandra chinensis residues and other six-flavored medicinal materials are crushed, added 5L of 60% ethanol, and put into microwave extraction Microwave extraction is carried out in the device, extraction power is 800W, extraction is 2 times, 10 minutes each time, the extracts are combined, concentrated, added to D101 macroporous ...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a preparation method and application of a liver benefiting tablet containing nepal dock root and day lily. The liver benefiting tablet is prepared by using 291g of nepal dock root, 103g of day lily, 92g of herb of raywort, 92g of yangtao, 92g of Smilax ocreafa A. DC, 62g of wild rose, 62g of swertia, 62g of pimoinella candolleana, and 62g of southern schisandra fruit as raw material, and adopting supercritical extraction, microwave extraction and macroporous resin absorption, so that the condition that the content of emodin is greatly improved is ensured. The invention also provides the application of the liver benefiting tablet to preparation of drug for restraining multiplication of a mouse leukemia cell L1210 cell.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method of Huangxuan Yigan Tablet and its application in the preparation of a medicine for inhibiting the proliferation of mouse leukemia cells L1210 cells. Background technique [0002] The standard number of Huangxuan Yigan San is WS-10465 (ZD-0465)-2002, which is recorded in the liver and gallbladder branch of the National Compilation of Chinese Patent Medicine Standards. It is made from 291g of rhubarb, 103g of daylilies, 92g of Senecio, 92g of kiwi, 92g of red soil Poria, 62g of wild rose, 62g of watercress, 62g of Saoyanggu, and 62g of southern Schisandra. effect. For chronic hepatitis B caused by liver and gallbladder damp heat. [0003] In the prior art, there is no Huangxuan Yigan powder that uses CO in the extraction and preparation. 2 There are reports of supercritical extraction, microwave technology and macroporous re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61K36/896A61K9/20A61P35/00
CPCA61K36/70A61K9/2059A61K36/185A61K36/23A61K36/28A61K36/515A61K36/57A61K36/738A61K36/79A61K36/896A61K36/90A61K2236/333A61K2236/37A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 权栋栋王洪涛刘艳辉权威宇胡乃合
Owner SHANDONG ZHONGDA PHARMA
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