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Hydrophilic coating and its preparation method and interventional device

A hydrophilic coating and device technology, applied in the field of medical devices, can solve the problems of poor adhesion and poor wear resistance of the hydrophilic coating, and achieve the effect of excellent friction resistance.

Active Publication Date: 2015-12-30
BEIJING DEMAX MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The invention provides a hydrophilic coating and its preparation method and interventional device, which solves the problems of poor abrasion resistance and poor adhesion of the hydrophilic coating

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0049] In addition, the present invention also provides the preparation method of above-mentioned hydrophilic coating, comprises the following steps:

[0050] S100: Apply the primer to the surface of the interventional device, and obtain the primer after curing.

[0051] Preferably, in step S100 , the primer is applied to the surface of the interventional device by spraying, dipping or brushing, and cured at 40° C. to 80° C. for 20 minutes to 60 minutes.

[0052] The primer comprises polyurethane acrylate-glycidyl acrylate copolymer, polyisocyanate and the first organic solvent, wherein the mass ratio of polyurethane acrylate-glycidyl acrylate copolymer to polyisocyanate is 1:(0.1~10), the first The mass of the organic solvent is 80wt%-99wt% of the total mass of the primer.

[0053] As a possible embodiment, the primer can be obtained by adding polyurethane acrylate-glycidyl acrylate copolymer, polyisocyanate and the first organic solvent into a container, and stirring at roo...

Embodiment 1

[0079] (1) Add urethane acrylate-glycidyl acrylate copolymer, triphenylmethane-4,4′,4″-triisocyanate and N,N-dimethylformamide into the container, stir at room temperature for 30min, Obtain primer; Wherein the mass ratio of urethane acrylate-glycidyl acrylate copolymer and triphenylmethane-4,4′,4″-triisocyanate is 1:1, the mass of N,N-dimethylformamide 95wt% of the total mass of the primer;

[0080] Add urethane acrylate-glycidyl acrylate copolymer, polymethyl vinyl ether-maleic anhydride and ethyl acetate into the container, and stir at room temperature for 30 minutes to obtain a top coat; where urethane acrylate-glycidyl acrylate The mass ratio of copolymer and polymethyl vinyl ether-maleic anhydride is 1:8, and the quality of ethyl acetate is 90wt% of the total mass of top coat;

[0081] Among them, polymethyl vinyl ether-maleic anhydride is a product of Sigma-Aldrich Company with a number average molecular weight of 80,000, and triphenylmethane-4,4′,4″-triisocyanate is a ...

Embodiment 2

[0087] (1) Add urethane acrylate-glycidyl acrylate copolymer, prepolymer of 2,4-toluene diisocyanate and tetrahydrofuran into a container, stir at room temperature for 20 minutes to obtain a primer; wherein urethane acrylate-glycidyl acrylate The mass ratio of the ester copolymer to the prepolymer of 2,4-toluene diisocyanate is 1:3, and the quality of tetrahydrofuran is 80wt% of the total mass of the primer;

[0088]Add urethane acrylate-glycidyl acrylate copolymer, polymethyl vinyl ether-maleic anhydride and methylene chloride into the container, stir at room temperature for 20min to obtain a top coat; where urethane acrylate-glycidyl acrylate The mass ratio of copolymer and polymethyl vinyl ether-maleic anhydride is 1:10, and the quality of dichloromethane is 99wt% of the total mass of top coat;

[0089] Among them, polymethyl vinyl ether-maleic anhydride is a product of Sigma-Aldrich Company with a number average molecular weight of 80,000, and the prepolymer of 2,4-toluene...

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Abstract

The invention discloses a hydrophilic coating layer and a preparation method thereof as well as an interventional device. The hydrophilic coating layer comprises a bottom coating layer and a top coating layer, wherein the bottom coating layer is formed by coating the surface of the interventional device with a bottom-layer coating; the top coating layer is formed by coating the surface of the bottom coating layer with a top-layer coating; the bottom-layer coating contains a urethane acrylate-glycidyl acrylate copolymer, polyisocyanates and a first organic solvent; the mass ratio of the urethane acrylate-glycidyl acrylate copolymer to the polyisocyanates is 1:(0.1-10); the mass of the first organic solvent is 80-99 weight percent of the total mass of the bottom-layer coating; the top-layer coating contains a urethane acrylate-glycidyl acrylate copolymer, PVME-maleic anhydride and a second organic solvent; the mass ratio of the urethane acrylate-glycidyl acrylate copolymer to the PVME-maleic anhydride is 1:(0.1-10); the mass of the second organic solvent is 80-99 weight percent of the total mass of the top-layer coating. The hydrophilic coating layer is excellent in friction resistance and hydrophilic lubrication performance.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a hydrophilic coating, a preparation method thereof and an interventional device. Background technique [0002] Endovascular interventional diagnosis and treatment technology is widely used in clinical angiography, angioplasty, removal of intravascular thrombus or foreign body, etc. Compared with traditional medical technology, endovascular interventional diagnosis and treatment technology is not only convenient to operate, but also because of the low trauma of interventional treatment, it can reduce the pain of patients, the risk of treatment is small, and the cost of treatment is relatively low. Therefore, this technology is widely used in medicine. field has been widely promoted and used. Intravascular interventional diagnosis and treatment technology uses interventional devices to reach distant diseased parts in the body, such as coronary arteries and other vascular parts, and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L29/08A61L31/10A61L29/12A61L31/12A61L29/14A61L31/14
Inventor 王兴元戴华英
Owner BEIJING DEMAX MEDICAL TECH