Hydrophilic aroma-enhancing humectant Mal-Hyp for tobacco, preparation method and application of humectant
A humectant, hydrophilic technology, applied in the field of preparation of a novel hydrophilic tobacco flavoring and humectant Mal-Hyp, to achieve high yield, good physical moisturizing effect, significant industrial application value and popularization and application. Effect
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Embodiment 1
[0028] A preparation method of hydrophilic tobacco flavoring and moisturizing agent Mal-Hyp, which comprises the steps of:
[0029] Add 1 gram of maltose, 1.3 mL of dimethylformamide and 2.9 mL of anhydrous methanol into a three-necked flask equipped with a thermometer and a condenser, reflux at 73°C for 16 minutes, then add 0.146 grams of hydroxyproline and reflux for another 16 minutes. Finally, 0.028 grams of strong acidic ion exchange resin and 0.160 grams of kaempferol were added for reflux reaction for 1.6 hours. After the reaction, 0.344 grams of the target product Mal-Hyp in the form of white crystals was obtained through silica gel column chromatography separation and recrystallization; The eluent used is a mixed solution of n-butanol, glacial acetic acid and water, the volume ratio of the three is 4:2:1, and the chromogenic agent is ninhydrin ethanol solution; the solvent used for recrystallization is a volume ratio of 1: 1 mixed solution of absolute ethanol and abso...
Embodiment 2
[0031] A preparation method of hydrophilic tobacco flavoring and moisturizing agent Mal-Hyp, which comprises the steps of:
[0032] Add 1 gram of maltose, 3.7 mL of dimethylformamide, and 2.0 mL of anhydrous methanol into a three-neck flask equipped with a thermometer and a condenser tube, reflux at 86°C for 30 minutes, then add 0.352 grams of hydroxyproline and reflux for another 30 minutes. Finally, 0.05 g of strong acidic ion exchange resin and 0.063 g of kaempferol were added for reflux reaction for 5 hours. After the reaction, 0.872 g of the target product in the form of white crystals was obtained through silica gel column chromatography and recrystallization. Wherein, the operation process of column chromatography separation and recrystallization is the same as that of Example 1.
Embodiment 3
[0034] A preparation method of hydrophilic tobacco flavoring and moisturizing agent Mal-Hyp, which comprises the steps of:
[0035] Add 1 gram of maltose, 4.0 mL of propylene glycol and 1.6 mL of anhydrous methanol into a three-necked flask with a thermometer and a condenser tube, reflux at 90°C for 45 minutes, then add 0.364 grams of hydroxyproline and reflux for another 45 minutes, and finally add 0.066 grams of The strongly acidic ion exchange resin and 0.802 g of kaempferol were refluxed for 9 hours. After the reaction, 0.616 g of the target product in the form of white crystals was obtained through silica gel column chromatography and recrystallization. Wherein, the operation process of column chromatography separation and recrystallization is the same as that of Example 1.
[0036] (1) Structural characterization of the target product
[0037] Through infrared spectroscopy (IR), high-resolution mass spectrometry (HR-MS), carbon nuclear magnetic resonance spectroscopy ...
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