A bottle of lipid microemulsion compound 13 kinds of vitamin freeze-dried preparation
A technology of freeze-dried preparations and fat-soluble vitamins, which is applied in the direction of freeze-dried delivery, drug combination, active ingredients of hydroxyl compounds, etc., to achieve the effects of avoiding side effects, ensuring dissolution, and avoiding the risk of contamination
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example 1
[0096] A bottle of lipid microemulsion compounded with 13 kinds of vitamin freeze-dried preparations prepared by different proportioning phospholipid emulsifier content of example 1
[0097] Example 1.1 Prescription:
[0098]
[0099] Preparation:
[0100] (1) Dissolve the vitamin A, vitamin D, vitamin E, and vitamin K in the above prescription amount in soybean oil in a 60°C water bath under the protection of nitrogen. After the dissolution is complete, add the prescription amount of egg yolk lecithin, and continue stirring until dissolved Then add the prescribed amount of poloxamer and polyethylene glycol-cephalin derivatives, and continue to stir and dissolve until the solution is clear to form an oil phase mixture. At the same time, dissolve the prescribed amount of sodium oleate and water for injection in a 60°C water bath to completely form a water phase mixture, then slowly add the water phase mixture to the oil phase mixture to form colostrum, and then place the co...
example 2
[0115] A bottle of lipid microemulsion compounded with 13 kinds of vitamin freeze-dried preparations prepared by different proportioning freeze-drying protective agent content of example 2
[0116] Example 2.1 Prescription:
[0117]
[0118] Preparation:
[0119] (1) Dissolve the vitamin A, vitamin D, vitamin E, and vitamin K of the above prescription amount in soybean oil in a water bath at 60°C under the protection of nitrogen. After the dissolution is complete, add the hydrogenated egg yolk lecithin of the prescription amount, and continue stirring to dissolve until After dissolving, add the prescribed amount of poloxamer and polyethylene glycol-cephalin derivatives, and continue to stir and dissolve until the solution is clear to form an oil phase mixture. At the same time, dissolve the prescribed amount of sodium oleate and water for injection in a 60°C water bath to completely form a water phase mixture, then slowly add the water phase mixture to the oil phase mixtur...
example 3
[0134] Example 3 A bottle of lipid microemulsion compounded with 13 kinds of vitamin freeze-dried preparations prepared by different proportioning reconstitution aid content
[0135] Example 3.1 Prescription:
[0136]
[0137] Preparation:
[0138] (1) Dissolve the vitamin A, vitamin D, vitamin E, and vitamin K in the above prescription amount in soybean oil in a 60°C water bath under the protection of nitrogen. After the dissolution is complete, add the prescription amount of egg yolk lecithin, and continue stirring until dissolved. Then add the prescribed amount of poloxamer and polyethylene glycol-cephalin derivatives, and continue to stir and dissolve until the solution is clear to form an oil phase mixture. At the same time, dissolve the prescribed amount of sodium oleate and water for injection in a 60°C water bath to completely form a water phase mixture, then slowly add the water phase mixture to the oil phase mixture to form colostrum, and then place the colostrum...
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