Sugar derived aroma enhancing humectant Mal-Trp used for tobaccos as well as preparation method and application thereof
A technology of sugar derivatives and humectants, applied in the field of humectants for cigarettes, to achieve good physical moisturizing effects, easy access to raw materials, and significant industrial application value
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Embodiment 1
[0028] A kind of preparation method of sugar derivative cigarette flavoring humectant Mal-Trp, it comprises the steps:
[0029] Add 1 gram of maltose, 0.7 mL of dimethylformamide, and 1.5 mL of anhydrous methanol into a three-necked flask equipped with a thermometer and a condenser, and reflux at 73°C for 15 minutes, then add 0.227 grams of tryptophan and reflux for another 15 minutes, and finally Add 0.026 g of strong acidic ion exchange resin and 0.018 g of myricetin for reflux reaction for 1.5 h; after the reaction, separate by silica gel column chromatography and recrystallize to obtain 0.503 g of the target product in the form of white crystals. Among them, the eluent used for column chromatography separation is a mixed solution composed of n-butanol, glacial acetic acid and water, the volume ratio of the three is 4:2:1, and the chromogenic agent is ninhydrin ethanol solution; the solvent used for recrystallization It is a mixed solution of absolute ethanol and absolute m...
Embodiment 2
[0031] A kind of preparation method of sugar derivative cigarette flavoring humectant Mal-Trp, it comprises the steps:
[0032] Add 1 gram of maltose, 1.0 mL of dimethylformamide, and 1.5 mL of anhydrous methanol into a three-necked flask with a thermometer and a condenser tube, reflux at 80°C for 30 minutes, then add 0.432 grams of tryptophan and reflux for another 30 minutes, and finally 0.036 g of strong acidic ion exchange resin and 0.068 g of myricetin were added for reflux reaction for 3.5 hours; after the reaction, 1.076 g of the target product in the form of white crystals was obtained through silica gel column chromatography and recrystallization. Wherein, the operation process of column chromatography separation and recrystallization is the same as that of Example 1.
Embodiment 3
[0034] A kind of preparation method of sugar derivative cigarette flavoring humectant Mal-Trp, it comprises the steps:
[0035] Add 1 gram of maltose, 1.5 mL of propylene glycol and 1.0 mL of anhydrous methanol into a three-necked flask with a thermometer and a condenser tube, reflux at 89°C for 45 minutes, then add 0.567 grams of tryptophan and reflux for another 40 minutes, and finally add 0.056 grams of strong The acidic ion exchange resin and 0.088 g of myricetin were refluxed for 7.5 hours; after the reaction, 0.777 g of the target product in the form of white crystals was obtained through silica gel column chromatography and recrystallization. Wherein, the operation process of column chromatography separation and recrystallization is the same as that of Example 1.
[0036] (1) Structural characterization of the target product
[0037] Through infrared spectroscopy (IR), high-resolution mass spectrometry (HR-MS), carbon nuclear magnetic resonance spectroscopy ( 13 C-N...
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