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A kind of determination method of content of various active ingredients in traditional Chinese medicine composition preparation

A determination method and composition technology, which are applied in measurement devices, material separation, analysis materials, etc., can solve the problems of long inspection period, many components, repeatability, and sensitivity cannot meet continuous production, and achieve fast analysis speed and repeatability. Good, easy-to-control effects

Active Publication Date: 2017-04-05
SHIJIAZHUANG YILING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to effectively control product quality and ensure public drug safety, quality control must be carried out on the intermediate links of the production process. However, the traditional Chinese medicine composition contains many ingredients, and the HPLC test cycle is long, and the repeatability and sensitivity cannot meet continuous requirements. production needs

Method used

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  • A kind of determination method of content of various active ingredients in traditional Chinese medicine composition preparation
  • A kind of determination method of content of various active ingredients in traditional Chinese medicine composition preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The raw material drug formula is:

[0048] Forsythia 255 g Honeysuckle 255 g Isatidis 255 g Rhubarb 51 g Patchouli 85 g

[0049] Mianma Guanzhong 255g Rhodiola 85g Menthol 7.5g Honey Ephedra 85g

[0050] Bitter almonds 85 g Houttuynia cordata 255 g Licorice 85 g Gypsum 255 g

[0051] The preparation method of Chinese medicine composition capsule is:

[0052] (1) Weigh Chinese herbal medicines according to the above prescription, and select them;

[0053] (2) Patchouli is broken, add 6 times the amount of water to extract the volatile oil, the oil extraction time is 4 hours, collect the volatile oil, and set aside; after the extract is filtered, the residue is discarded, and the filtrate is set aside;

[0054] (3) Forsythia, Ephedra, Houttuynia cordata, and rhubarb, extract twice with 8 times the amount of 70% ethanol, the first time for 2 hours, and the second time for 1.5 hours, the extracts are combined and filtered, the ethanol is recovered, and the filtrate is us...

Embodiment 2

[0068] The raw material drug formula is:

[0069] Forsythia 300 g Honeysuckle 200 g Radix Isatidis 300 g Rhubarb 60 g Patchouli 100 g

[0070] Mianma Guanzhong 200g Rhodiola 60g Menthol 5g Ephedra 100g

[0071] Bitter almonds 60 g Houttuynia cordata 300 g Licorice 60 g Gypsum 300 g

[0072] The preparation method of Chinese medicine composition tablet is:

[0073] (1) Weigh Chinese herbal medicines according to the above prescription, and select them;

[0074] (2) Patchouli is broken, add 5 times the amount of water to extract the volatile oil, the oil extraction time is 4 hours, collect the volatile oil, and set aside; after the extract is filtered, the residue is discarded, and the filtrate is set aside;

[0075] (3) Forsythia, Ephedra, Houttuynia cordata, and rhubarb, extract twice with 6 times the amount of 50% ethanol, the first time for 3 hours, and the second time for 1 hour, the extracts are combined and filtered, the ethanol is recovered, and the filtrate is used f...

Embodiment 3

[0093] The raw material drug formula is:

[0094] Forsythia 200g Honeysuckle 300g Radix Isatidis 200g Rhubarb 60g Patchouli 60g

[0095] Mianma Guanzhong 300g Rhodiola 60g Menthol 9g Ephedra 60g Bitter Almond 100g

[0096] Houttuynia cordata 200g, licorice 100g, gypsum 200g.

[0097] The pill preparation method of Chinese medicine composition is:

[0098] (1) Weigh Chinese herbal medicines according to the above prescription, and select them;

[0099] (2) Patchouli is broken, add 10 times the amount of water to extract the volatile oil, the oil extraction time is 4 hours, collect the volatile oil, and set aside; after the extract is filtered, the residue is discarded, and the filtrate is set aside;

[0100] (3) Forsythia, Ephedra, Houttuynia cordata, and rhubarb, extract twice with 10 times the amount of 90% ethanol, the first time for 1 hour, and the second time for 3 hours, the extracts are combined and filtered, the ethanol is recovered, and the filtrate is used for late...

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Abstract

The invention discloses a content determination method for multiple active compositions in a traditional Chinese medicine composition preparation, and belongs to the field of traditional Chinese medicines. The concrete preparation steps comprise preparation of a test sample solution, preparation of a reference sample solution, UPLC detection, making of a standard curve and result calculation. The determination method is short in period and high in sensitivity.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine analysis, and in particular relates to a method for determining the content of traditional Chinese medicine components. Background technique [0002] The traditional Chinese medicine composition has the effects of detoxifying and detoxifying, clearing the lungs and expeling heat, and is suitable for the treatment of influenza. Reddish, yellow or greasy fur, etc. The main ingredients include forsythia, honeysuckle, roasted ephedra, fried bitter almonds, gypsum, isatid root, Mianma Guanzhong, houttuynia cordata, patchouli, rhubarb, rhodiola, menthol, licorice. [0003] In order to effectively control product quality and ensure public drug safety, it is necessary to carry out quality control on the intermediate links of the production process. However, there are many components in the traditional Chinese medicine composition, and the HPLC test cycle is long, and the repeatability and sens...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/88
Inventor 刘敏彦赵韶华叶晓红张永锋范文成王海亮张静
Owner SHIJIAZHUANG YILING PHARMA