Automatic analysis apparatus and automatic analysis method

An automatic analysis device and analysis reagent technology, applied in the direction of analysis materials, instruments, etc., can solve the problems of reducing the sensitivity and measurement range of test items, limiting test flexibility, and large instrument volume, so as to achieve high-speed testing, easy high-speed testing, The effect of reducing the volume of the whole machine

Inactive Publication Date: 2015-02-11
SUZHOU HAOOUBO BIOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This fixed movement limits the flexibility of the test. Each test can only be performed in strict order, and the operations of adding reaction vessels, adding samples, reaction incubation, cleaning and separation, and detection are completed according to the same test process. For example, the instrument can only perform One-step or two-step test mode (one-step method refers to cleaning and separation once, two-step method refers to cleaning and separation twice), the reaction time of each test must also be fixed
This unified and fixed reaction process mode and reaction incubation time (referred to as reaction time) cannot be optimal for all test items, thus reducing the performance of some test items such as sensitivity and measurement range
On the other hand, in order to support the two-step analysis mode, this implementation requires at least two sets of cleaning

Method used

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  • Automatic analysis apparatus and automatic analysis method
  • Automatic analysis apparatus and automatic analysis method
  • Automatic analysis apparatus and automatic analysis method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment one: see attached figure 1 shown.

[0059] An automatic analysis device 1, which includes a reaction container supply unit 9, a reagent chamber unit 8, a sample transfer unit 7, a reaction incubation unit 2, a cleaning and separation unit 3, a detection unit 4, a sample adding unit 6, a transfer unit 5, a control unit The system 100 includes a mixing unit 11 , a cleaning device, a reaction container recovery area 16 , a detection reagent loading area 17 , a waste liquid recovery area 18 , and a liquid supply area 19 .

[0060] Each part is described in detail below.

[0061] The reaction container supply unit 9 is used for accommodating and providing the reaction containers required for the analysis test, wherein several reaction containers are placed, and the reaction container supply unit 9 has a container supply position. For example, the reaction container supply unit 9 accommodates 1000 reaction containers at a time. In order to reduce the contaminatio...

Embodiment approach

[0069] The first embodiment is as figure 1 As shown: the injection of the detection reagent after cleaning and separation can be completed on the cleaning and separation unit 3, that is, in this embodiment, the detection reaction incubation position of the detection unit 4 is integrated in the cleaning and separation unit 3, and the detection reaction incubation position corresponds to A detection reagent injection mechanism is provided. After the detection reagent injection mechanism injects the detection reagent into the reaction container, the detection reaction is completed at the detection reaction incubation position on the cleaning separation unit 3, and the reaction usually takes several minutes, such as 3 minutes. In this way, the resources on the cleaning and separation unit 3 can be fully utilized and cost saved.

[0070] The second embodiment is as Figure 10 Shown: the detection reaction incubation position of the detection unit 4 is located on an independent de...

Embodiment 2

[0111] Embodiment two: see attached Figure 7 shown, with figure 1 Compared with the first embodiment shown, the difference lies in the sample adding unit 6 and the cleaning unit. The horizontal trajectory of the sample loading unit 6 is a straight line, which can move along the horizontal linear guide rail and vertically up and down. The horizontal trajectory intersects the sample transfer unit 7, the reaction incubation unit 2 and the reagent chamber unit 8 respectively. The horizontal movement of the sample adding unit 6 can improve the positioning accuracy, and can also make the whole machine more compact. The cleaning unit changes from a single circle to at least one circle. In this embodiment, the cleaning and separation unit 3 has two circles, the inner circle 3a completes the cleaning and separation and the dispensing of detection liquid, and the outer circle 3b completes the detection reaction, so that the functional division is more independent The cleaning, separa...

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Abstract

The invention relates to an automatic analysis apparatus. The apparatus includes a reaction container supply unit, a reagent warehouse receipt, a sample transfer unit, a reaction incubation unit, a cleaning and separating unit, a detection unit, a sample adding unit, a transfer unit and a control system. An automatic analysis method using the automatic analysis apparatus includes the following steps: (1) supplying a reaction container; (2) adding an analysis sample and an analysis reagent; (3) reacting; (4) cleaning, and separating; (5) adding a detection reagent; (6) reacting; and (7) detecting. The automatic analysis apparatus and the automatic analysis method can flexibly realize a variety of test modes and reaction times, reduce the size of a whole machine, reduce the cost, and make the whole machine have a compact structure; and the automatic analysis apparatus has scalability, can easily realize high speed test, and is suitable for analysis under different test modes and reaction times.

Description

technical field [0001] The invention relates to an analysis instrument and analysis method, in particular to an automatic immune analysis instrument and a method for using the instrument to perform immune analysis. Background technique [0002] Immunoassay is an analytical method that uses antigen-antibody specific binding reactions to detect trace substances such as proteins, hormones, and drugs. Immunoassays can be divided into non-labeled immunoassays and labeled immunoassays. Labeled immunoassay technology has experienced the development of radioimmunoassay, enzyme immunoassay, fluorescence immunoassay, time-resolved fluorescence immunoassay and chemiluminescence immunoassay. Chemiluminescence Immunoassay (CLIA) is a detection and analysis technology that combines high-sensitivity chemiluminescence assay technology with high-specificity immune response. It has high sensitivity, strong specificity, wide detection range, and safe and convenient operation. As well as the ...

Claims

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Application Information

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IPC IPC(8): G01N35/00
CPCG01N35/025G01N35/0098G01N2035/00356G01N2035/00564G01N2035/0446
Inventor 约翰·李
Owner SUZHOU HAOOUBO BIOPHARML
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