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Intraocular lens loaded with drug slow-releasing thin layers on loop surfaces

A technology of intraocular lens and medicine, which is applied in the fields of intraocular lens, prosthesis, medical science, etc., can solve the problem that the slow release time and concentration of medicine cannot meet the requirements of clinical application, the inhibitory effect and degree of endophthalmitis are uncertain, and the intraocular Other tissue toxicity and side effects, to achieve the effect of inhibiting microorganisms in the eye, improving long-term vision, and antagonizing inflammatory reactions

Inactive Publication Date: 2015-02-18
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although they can inhibit endophthalmitis to a certain extent by improving the surface properties or stimulating surrounding inflammatory substances, they still have the following disadvantages: 1) the scope of influence is limited to the surface of the intraocular lens or the nearby area, and the antibacterial ability is limited; 2) hydrophilic The inhibitory effect and inhibitory degree of sex or free radicals on endophthalmitis are uncertain, and the adjustability is not high
3) The sustained release time and concentration of the drug cannot meet the requirements of clinical application
Although the above method can inhibit the proliferation of residual lens epithelial cells through in situ antibody inhibition or local concentration of drugs, it can only play a role through contact antibody inhibition, and the range of inhibition is small; or the formed drug coating Poor stability, high possibility of drug release, which may have toxic side effects on other tissues in the eye

Method used

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  • Intraocular lens loaded with drug slow-releasing thin layers on loop surfaces
  • Intraocular lens loaded with drug slow-releasing thin layers on loop surfaces
  • Intraocular lens loaded with drug slow-releasing thin layers on loop surfaces

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] In this embodiment, the manufacturing method of the intraocular lens with the drug slow-release thin layer on the haptic surface includes the following steps:

[0035] Put 600mg of gatifloxacin powder and 1400mg of glyceryl tristearate powder into a glass beaker, heat and stir the beaker in a water bath at 80°C until the solid melts; area immersed in the liquid) completely immersed in the above-mentioned molten liquid for 1 second, then quickly take it out and cool it down to obtain an intraocular lens with a thin layer of drug sustained release on the surface of the loop; after that, it is sterilized with ethylene oxide and packaged in a sealed manner.

Embodiment 2

[0037] Put 700mg of fleroxacin powder and 1800mg of stearic acid powder into a glass beaker, heat and stir the beaker in a 75°C water bath until the solid melts; ) is completely submerged in the above-mentioned molten solution for 1 second, then quickly taken out and cooled to obtain an intraocular lens with a drug sustained-release thin layer on the surface of the loop; after that, ethylene oxide is sterilized and packaged in a sealed manner.

Embodiment 3

[0039] Put 400mg of clarithromycin powder, 800mg of stearic acid powder, and 600mg of PLGA into a glass beaker, heat and stir the beaker in a water bath at 85°C until the solid melts; (in the liquid) completely submerged in the above-mentioned molten liquid for 1 second, then quickly take it out and cool it down, and then the intraocular lens with a drug slow-release thin layer on the surface of the loop can be obtained; after that, it is sterilized with ethylene oxide and sealed in a package.

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Abstract

The invention relates to an intraocular lens loaded with drug slow-releasing thin layers on loop surfaces. The purpose of the invention is that the provided intraocular lens can effectively prevent and control microbial infection and antagonism inflammatory response after a cataract surgery, reduce the occurrence rate of intraocular inflammation after the cataract surgery and prevent and inhibit after-cataract, therefore improving the postoperative visual quality; at the same time, the stability on aspects such as optics and mechanics of the intraocular lens is not influenced; the intraocular lens does not have a toxic or side effect on intraocular tissues such as the corneal endothelium of a body, epithelial cells of a ciliary body, irises, choroids, retina and the like; the provided production method is simple, mature and practical, the cost of raw materials is low, and industrialized mass production can be realized. According to the technical scheme, the intraocular lens loaded with the drug slow-releasing thin layers on the loop surfaces comprises an optical part and at least two loops symmetrically arranged on the side edge of the optical part. The intraocular lens is characterized in that the surfaces of the loops are coated with the drug slow-releasing thin layers, and the thin layers contain antibacterial or / and anti-inflammatory or / and after-cataract cataract resisting drugs.

Description

technical field [0001] The invention relates to a foldable intraocular lens used for replacing the intraocular lens in femtosecond laser cataract surgery and phacoemulsification cataract extraction, in particular to a foldable intraocular lens capable of inhibiting microbial infection after cataract surgery, antagonizing inflammatory reactions, preventing and inhibiting postoperative An intraocular lens with a slow-release drug layer on the surface of the haptics in cataract. Background technique [0002] Cataract is the leading cause of blindness in the world; surgical removal of cataract and implantation of intraocular lens is currently the only effective way to treat cataract. Cataract surgery is quite mature, but there are still potential postoperative complications that may lead to postoperative vision loss or even blindness, such as infectious endophthalmitis and post-cataract after cataract surgery. Infectious endophthalmitis refers to the destructive inflammatory re...

Claims

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Application Information

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IPC IPC(8): A61F2/16A61L27/54
Inventor 姚克丁文婷
Owner ZHEJIANG UNIV
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