Oil-in-water type compound lomefloxacin nano-emulsion

A technology of compound lomefloxacin and lomefloxacin, which is applied in the field of medicine, can solve the problems that the drug effect of lomefloxacin cannot be fully utilized, the central nervous system is damaged, and the drug dissolution rate is slow, so as to reduce gastrointestinal adverse reactions, Improve drug efficacy and reduce kidney damage

Inactive Publication Date: 2015-02-25
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, there are many dosage forms of lomefloxacin on the market, such as capsules, ointments, and dispersible tablets of lomefloxacin, but because lomefloxacin is insoluble in water, the dissolution rate of the drug is slow and the bioavailability is poor, making lomefloxacin The efficacy of the star cannot be fully utilized, and increasing the dosage will cause damage to the central nervous system, etc.

Method used

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  • Oil-in-water type compound lomefloxacin nano-emulsion
  • Oil-in-water type compound lomefloxacin nano-emulsion
  • Oil-in-water type compound lomefloxacin nano-emulsion

Examples

Experimental program
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Effect test

Embodiment 1-14

[0055] The components and their contents of Examples 1-14 are shown in Table 1.

[0056]

[0057] Its preparation method is as follows:

[0058] 1) Weigh lomefloxacin, surfactant and co-surfactant, water extract of Houttuynia cordata and water according to the above weight; 2) Stir lomefloxacin, oil, surfactant and co-surfactant at room temperature Obtaining an oil phase solution uniformly; 3) Dissolving the water extract of Houttuynia cordata in water to obtain an aqueous phase solution; 4) Adding the aqueous phase solution into the oil phase solution and stirring evenly to obtain a nanoemulsion.

Embodiment 15

[0059] Embodiment 15: test

[0060] 15.1 Particle size analysis

[0061] The nanoemulsion products of Examples 1-14 were observed under a transmission electron microscope, and it was found that the droplets were spherical in shape, had good dispersion and no adhesion. figure 1 It is the transmission electron micrograph of embodiment 1 compound lomefloxacin antibacterial emulsion. The nanoemulsion of embodiment 1 is detected by Malvern particle size analyzer, and the detection result is as follows: figure 2 As shown, it can be seen from the figure that the particle size distribution of the emulsion is between 25.8 and 61.0 nm, and the average particle size is 43.5 nm.

[0062] Stability Analysis

[0063] Get the nanoemulsion product of embodiment 1-14 and carry out high-speed centrifugation test, photostability test, temperature stability test etc. respectively, observe the stability of compound lomefloxacin antibacterial milk of the present invention, confirm whether...

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Abstract

The invention discloses an oil-in-water type compound lomefloxacin nano-emulsion, belonging to the technical field of medicines. The nano-emulsion comprises the following components in parts by weight: 1-20 parts of herba houttuyniae aqueous extract, 5-40 parts of surfactant, 1-15 parts of co-surfactant, 1-25 parts of lomefloxacin, 1-25 parts of oil and 20-70 parts of water. The nano-emulsion disclosed by the invention is relatively narrow in latex particle size distribution, transparent in system and good in stability, has relatively low surface tension and very good fluidity, is convenient to take, and improves the solubility and penetrability of lomefloxacin to ensure that the bioavailability of a medicament is improved; and the herba houttuyniae aqueous extract is compounded with lomefloxacin, so that the antibacterial abilities of the two are mutually promoted, and the antibacterial effect is more stable.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to an oil-in-water nanoemulsion—a compound antibacterial emulsion with Houttuynia cordata water extract and lomefloxacin as active ingredients. Background technique [0002] Lomefloxacin, Lomefloxacin (Bareon), is a third-generation quinolone antibacterial drug with a broad antibacterial spectrum. Its antibacterial activity against Gram-positive bacteria is the same as Norfloxacin, and stronger than Enoxacin; The effect is the same as that of enoxacin, but weaker than that of norfloxacin. [0003] Pharmacodynamics: Lomefloxacin is a kind of difluoroquinolic acid, which is a synthetic broad-spectrum antibiotic. Its antibacterial mechanism is the activity of bacterial DNA helicase, thereby inhibiting the synthesis of bacterial DNA. [Toxicology] Like all quinolones, the animal toxicity tests of lomefloxacin have the following phenomena: Joint lesions: Lomefloxacin affec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61K9/107A61P31/04A61K31/496
CPCA61K36/78A61K9/1075A61K31/496A61K47/34A61K47/44
Inventor 孙江宏阮心洁岳旭龙
Owner HENAN SOAR VETERINARY PHARMA
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