Oil-in-water type neomycin sulfate nosiheptide nanoemulsion antimicrobial medicine

A technology of neomycin sulfate and antibacterial drugs, applied in the field of medicine, can solve the problems of less absorption, achieve low surface tension, better antibacterial effect, and good effect

Inactive Publication Date: 2015-02-25
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Most of the medicines are neomycin sulfate oral tablets, but they are seldom absorbed orally, and need to be taken orally for a long time to increase the dosage, which is easy to cause adverse reactions such as loss of appetite, nausea, and diarrhea. Based on the above problems, the present invention aims to pass Change the dosage form to improve the body's ability to absorb and operate the drug, reduce the rate of adverse reactions, and improve its therapeutic effect

Method used

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  • Oil-in-water type neomycin sulfate nosiheptide nanoemulsion antimicrobial medicine
  • Oil-in-water type neomycin sulfate nosiheptide nanoemulsion antimicrobial medicine
  • Oil-in-water type neomycin sulfate nosiheptide nanoemulsion antimicrobial medicine

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Embodiment example

[0032] Example Nosiheptide / g Neomycin sulfate / g Surfactant / g Co-surfactant / g Oil / g Water / g 16.17.6 28 (EL-40) 4 (ethanol) 12 (cinnamaldehyde)42.3 26.57.9 25 (EL-40) 3 (1,2-Propanediol) 14 (linoleic acid)43.6 35.56.5 28 (RH-40) 7 (Glycerol) 11 (castor oil)42 44.22.2 35 (RH-40) 5 (ethanol) 12 (Ethyl oleate)41.6 54.52.5 25 (Tween 80) 15 (glycerol) 13 (cinnamaldehyde)40 64.59.8 20 (Tween 80) 4 (Polyethylene glycol 400) 16 (soybean oil) 45.7

[0033] Preparation method: accurately weigh out nosiheptide, surfactant and co-surfactant, stir evenly at room temperature (25°C), and then slowly drip distilled water into which neomycin sulfate has been dissolved; with the amount of distilled water The viscosity of the system increases when the amount of distilled water is added to change the system from water-in-oil to oil-in-water nanoemulsion, the viscosity of the system becomes thinner from the most viscous state, and nothing is produced. Transparent neomycin sulfate and nosiheptide na...

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Abstract

The invention relates to an oil-in-water type neomycin sulfate nosiheptide nanoemulsion antimicrobial medicine which is a nanoemulsion preparation taking neomycin sulfate and nosiheptide as effective components. The antimicrobial medicine comprises the following components in parts by weight: 1 to 20 parts of neomycin sulfate, 15 to 35 parts of surfactant, 0 to 20 parts of cosurfactant, 1 to 25 parts of nosiheptide, 1 to 25 parts of oil and 20 to 70 parts of distilled water. The antimicrobial medicine has a good pharmacological function and an excellent antimicrobial effect via combination of neomycin sulfate and nosiheptide, and is very simple in preparation method and easy to popularize.

Description

Technical field [0001] The invention belongs to the field of medicine, and in particular relates to an antibacterial drug, specifically an oil-in-water type neomycin sulfate and nasitide nanoemulsion antibacterial drug. Background technique [0002] Neomycin sulfate, English names Neomycin Sulphate, mycifradin sulfate, CAS:1405-10-3, EINECS:215-773-1, molecular formula: C 23 H 48 N 6 O 17 S, molecular weight: 712.7222. Neomycin sulfate is an aminoglycoside antibiotic, containing 2-deoxystreptamine structure, which can inhibit the biosynthesis of protein, thereby achieving the effect of inhibiting bacteria and having a strong antibacterial effect in alkaline solutions. It has a strong bactericidal effect on Gram-negative bacteria and some Gram-positive bacteria, and has an inhibitory effect on Actinomyces, Leptospira and Amoeba. Commonly used to treat and control infections caused by neomycin sulfate-sensitive bacteria (E. coli, Shigella, Staphylococcus aureus, Salmonella, Arizon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/12A61K9/107A61P31/04A61K31/7036
Inventor 孙江宏高贵超
Owner HENAN SOAR VETERINARY PHARMA
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