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Quality control reference substance for antelope's horn tablets for common cold and application of quality control reference substance

A technology of Ganmao tablets and reference products, which is applied in the chromatographic conditions stipulated in the standard and conforms to all chromatographic columns. The field of quality control reference products of Lingyang Ganmao tablets achieves the effect of strong adaptability and great application potential.

Inactive Publication Date: 2015-02-25
SHANDONG INST FOR FOOD & DRUG CONTROL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem that there is no relevant record of the quality control reference product of Lingyang Ganmao Tablets in the above prior art, the present invention provides a quality control reference product of Lingyang Ganmao Tablets

Method used

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  • Quality control reference substance for antelope's horn tablets for common cold and application of quality control reference substance
  • Quality control reference substance for antelope's horn tablets for common cold and application of quality control reference substance

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Effect test

Embodiment 1

[0029] 1 Instruments and reagents

[0030] Instruments: Agilent 1200 high-performance liquid chromatography; Sartorius CP225D electronic analytical balance; BK-600C ultrasonic cleaner (Barker Ultrasonic Equipment Co., Ltd.).

[0031] Reagent: chlorogenic acid (110753-200414), vitexin rhamnoside (111687-200602), isorhamnetin-3-O-neohesperidin (111571-200402), forsythin (110821-200508 ), forsythiaside A (111810-201001, with a content of 94.3%), and arctiin (110819-201007, with a content of 94.6%) were all provided by the China Institute for Food and Drug Control. Acetonitrile was chromatographically pure.

[0032] 2 Methods and results

[0033] 2.1 Selection of reference products

[0034] 2.1.1 Preparation of mixed reference solution

[0035] Prepare a certain concentration of chlorogenic acid, liquiritin, vitexin rhamnoside, isorhamnetin-3-O-neohesperidin, forsythiaside A, forsythin and arctiin reference substance 50% methanol For the stock solution, accurately measure an ...

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Abstract

The invention relates to the technical field of drug quality control and in particular relates to a quality control reference substance for antelope's horn tablets for common cold. The retention time of chlorogenic acid, liquiritin, rhamnosylvitexin, isorhamnetin-3-O-neohesperidin, forsythoside A, forsythin and arctiin is respectively 9.954, 38.591, 39.767, 43.191, 43.807, 60.715 and 62.065 minutes, the separation degree of each component from the adjacent peak is higher than 1.5, and the numbers of theoretical plates are respectively 10940, 49640, 22085, 257778, 205587, 376909 and 499904. According to the reference substance, multiple Chinese patent medicines and traditional Chinese medicinal materials can be qualitatively, semi-quantitatively and quantitatively researched, and the reference substance has the characteristics of convenience, rapidness, accuracy and high adaptability and has high application potentials.

Description

technical field [0001] The invention relates to the technical field of medicine quality control, in particular to a reference product for quality control of Lingyang Ganmao Tablets, and also relates to its application. Background technique [0002] At present, the quality standards of Chinese patent medicines are playing an increasingly important role in controlling the quality of Chinese medicines. In particular, the relevant standards contained in the 2010 edition of "Chinese Pharmacopoeia" and its supplements have greatly improved compared with the previous editions. In addition to the TLC identification items related to the flavor of the medicine, more content determination items have been added, but each item basically controls a certain flavor of the medicine in the prescription, lacks the overall control of the quality of traditional Chinese medicine, and pays attention to the composition of prescriptions in clinical medicine of traditional Chinese medicine. The who...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 王玉团胡德福林晓刘群许丽丽
Owner SHANDONG INST FOR FOOD & DRUG CONTROL
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