Preparation method of carboxymethyl pachyman and novel application of carboxymethyl pachyman

A technology of carboxymethyl tuckahoe and tuckahoe polysaccharide, which is applied in the field of natural medicinal chemistry, can solve the problems of low efficiency, long duration, other effects and applications that have not been reported, and achieve easy operation, short reaction time, and improved vaccine immunity The effect of potency

Active Publication Date: 2015-03-04
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the equipment and reaction medium have been greatly improved, the duration of the reaction is too long, usually forty to fifty hours, and the efficiency is low
[0006] At the same time, the current research on the application of carboxymethylpachyran only involves the anti-tumor application of human medicine, and there are no relevant reports on other effects and applications.

Method used

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  • Preparation method of carboxymethyl pachyman and novel application of carboxymethyl pachyman
  • Preparation method of carboxymethyl pachyman and novel application of carboxymethyl pachyman
  • Preparation method of carboxymethyl pachyman and novel application of carboxymethyl pachyman

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Experimental program
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Effect test

Embodiment 1

[0043] Embodiment 1 (the preparation method of carboxymethyl pachymane)

[0044] A method for preparing carboxymethyl pachyrhin, specifically comprising the following steps:

[0045] Take 1000g of Poria cocos sclerotia, dry and pulverize to obtain Poria cocos micropowder; add Poria cocos micropowder to 6L, 80% benzyl alcohol solution, stir evenly, add 150g of sodium hydroxide, stir for 1 hour, obtain Poria cocos polysaccharide extract; 150g of hydroxide Add sodium to chloroacetic acid and react for 1 hour to obtain chloroacetic acid alkalization solution; add chloroacetic acid alkalinization solution to the extract of pachyrhiza polysaccharide, add 100 g of polyethylene glycol to the reaction solution, and fully stir at 50°C for 3 hours Carry out the substitution reaction, after the reaction is finished, adjust the solution to neutral, collect the precipitate by filtration, wash thoroughly with absolute ethanol three times, and filter and dry to obtain carboxymethylpachyan.

Embodiment 2

[0046] Embodiment 2 (the preparation method of carboxymethyl pachymane)

[0047] A method for preparing carboxymethyl pachyrhin, specifically comprising the following steps:

[0048] Take 1000g of Poria cocos sclerotia, dry and pulverize to obtain Poria cocos micropowder; add Poria cocos micropowder to 13.7L, 95% glycerol solution, stir evenly, add 250g of sodium hydroxide, stir for 5h, and obtain Poria cocos polysaccharide extract; mix 250g Sodium hydroxide is added in the chloroacetic acid and reacts 5h, obtains chloroacetic acid basification liquid; Chloroacetic acid basification liquid is joined in the Poria cocos polysaccharide extraction liquid, adds 200g benzyltriethyl ammonium chloride in reaction solution, in Thoroughly stir at 80°C for 6 hours to carry out the substitution reaction. After the reaction, adjust the solution to neutrality, collect the precipitate by filtration, wash thoroughly with absolute ethanol three times, and filter and dry to obtain carboxymethyl...

Embodiment 3

[0049] Embodiment 3 (the preparation method of carboxymethyl pachymane)

[0050] A method for preparing carboxymethyl pachyrhin, specifically comprising the following steps:

[0051] Take 1000g of Poria cocos sclerotia, dry and pulverize to obtain Poria cocos micropowder; add Poria cocos micropowder to 10L, 85% propanol solution, stir evenly, add 200g of sodium hydroxide, stir for 3 hours to obtain Poria cocos polysaccharide extract; 200g of hydroxide Sodium was added in the chloroacetic acid and reacted for 3h to obtain the chloroacetic acid alkalization solution; the chloroacetic acid alkalization solution was added in the polysaccharide extract, and 150g chain polyethylene glycol dialkyl ether was added to the reaction solution, and the Fully stir at 65°C for 4.5 hours to carry out the substitution reaction. After the reaction, adjust the solution to neutrality, collect the precipitate by filtration, wash thoroughly with absolute ethanol three times, and filter and dry to o...

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Abstract

The invention provides a preparation method of carboxymethyl pachyman and a novel application of the carboxymethyl pachyman. According to the method, in the process of carrying out carboxymethylation modification on pachymaran, components and ratios of a reaction medium are changed, the reaction temperature is regulated and a catalyst process is adopted, so that the carboxymethylation efficiency of the pachymaran is remarkably improved, the utilization rate of the raw and auxiliary materials is increased, and the cost is saved. Meanwhile, by virtue of the novel application of the carboxymethyl pachyman prepared by the method to preparation of immunopotentiators of livestock and poultry, the immunity to pathogenic microorganisms of the livestock and the poultry can be remarkably enhanced, and the immune efficacy of vaccines can be improved; by virtue of the novel application of the arboxymethyl pachyman prepared by the method to feed additives, the meat performance of the livestock and the poultry can be effectively improved.

Description

technical field [0001] The invention relates to the technical field of natural medicine chemistry, in particular to a preparation method of carboxymethyl pachymane and its new application. Background technique [0002] Poria [Poria cocos (Schw.) Wolf] is a fungus used for food and medicine. It is one of the "four monarchs and eight treasures" of traditional Chinese medicine. Tumor, diuresis and swelling, enhance immunity, calm the nerves and inhibit bacteria and other functions. Poria cocos contains a variety of chemical components, the most important of which is polysaccharide, and its content can reach 84% of the dry weight of Poria cocos. Poria cocos polysaccharide has a wide molecular weight distribution, the large molecular weight can reach 1 million Daltons, and the small molecular weight ones are distributed between 5000-9000 Daltons. Poria cocos polysaccharide is easily soluble in medium and strong alkaline solutions, but hardly soluble in water. Its main structure...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A23K1/16A61K31/715A61K39/39A61K39/245A61P31/22A61P37/04
Inventor 彭江宁赵越超夏雪林刘拓刘爱玲李旭东
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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