Ultrasonic/magnetic resonance bimodal contrast agent and its preparation method and use

A dual-modality contrast agent, magnetic resonance technology, applied in the direction of MRI/MRI contrast agent, general/multifunctional contrast agent, echo/ultrasonic imaging agent, etc., to achieve clinical judgment, avoid oxidation, preparation process simple effect

Active Publication Date: 2015-03-11
SUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The purpose of the present invention is to provide an ultrasound / magnetic resonance dual-mode contrast agent and a preparation method thereof; the obtained ultrasound / magnetic resonance dual-mode contrast agent has the functions of ultrasound contrast imaging and magnetic resonance contrast imaging simultaneously, solving the problem of traditional clinical practice One kind of contrast medium can only be used for one kind of imaging means to check all kinds of inconveniences

Method used

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  • Ultrasonic/magnetic resonance bimodal contrast agent and its preparation method and use
  • Ultrasonic/magnetic resonance bimodal contrast agent and its preparation method and use
  • Ultrasonic/magnetic resonance bimodal contrast agent and its preparation method and use

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Embodiment 1

[0029] Embodiment 1: A method for preparing an ultrasound / magnetic resonance dual-mode contrast agent, comprising the following steps:

[0030] (1) Weigh 1.0 g of superparamagnetic iron oxide nanoparticles and disperse them in 99 g of deionized water, ultrasonically disperse them in a water bath for 5 min, adjust the pH value to 6.0 with hydrochloric acid, and prepare a stable, uniform and fluid mixture. suspension;

[0031] (2) The above suspension is pumped to a spray dryer by a self-priming peristaltic pump for spray drying treatment. The spray drying conditions are: inlet air temperature 140°C, feed flow rate 5.0 mL / min, compressed nitrogen flow rate 280 L / h.

[0032] The hollow spherical nanoparticle aggregate obtained by spray drying is collected, which is the ultrasound / magnetic resonance dual-mode contrast agent.

Embodiment 2

[0033] Embodiment 2: A method for preparing an ultrasound / magnetic resonance dual-mode contrast agent, comprising the following steps:

[0034] (1) Prepare citric acid-modified superparamagnetic iron oxide nanoparticles by co-precipitation method;

[0035] Weigh 0.86gFeCl 2 and 2.35gFeCl 3 To a four-neck flask, add 40mL of water and sonicate for 5min; stir under nitrogen protection; heat up to 80°C, slowly add 5mL of ammonia water dropwise, and continue the reaction for 30min; slowly add citric acid solution dropwise into the reaction system; The reaction temperature was raised to 95° C., and the reaction was continued for 90 minutes. The black precipitate obtained in the water washing reaction obtains the superparamagnetic iron oxide nanoparticles modified by citric acid;

[0036] (2) Weigh 1.5 g of the above-mentioned citric acid-modified superparamagnetic iron oxide nanoparticles and disperse them in 98.5 g of deionized water, ultrasonically disperse them in a water bath...

Embodiment 3

[0041] Embodiment 3: A method for preparing an ultrasound / magnetic resonance dual-mode contrast agent, comprising the following steps:

[0042] (1) Weigh 3 g of citric acid-modified superparamagnetic manganese oxide nanoparticles and disperse them in 97 g of deionized water, ultrasonically disperse them in a water bath for 5 min, adjust the pH value to 7.5, and prepare a stable, uniform, and good fluidity suspension.

[0043] (2) Pump the above suspension to a spray dryer through a self-priming peristaltic pump for spray drying treatment. Spray drying conditions: inlet air temperature 130°C, feed flow rate 5.0 mL / min, compressed nitrogen flow rate 280 L / h.

[0044] The hollow spherical nanoparticle aggregate obtained by spray drying is collected, which is the ultrasound / magnetic resonance dual-mode contrast agent.

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Abstract

The invention relates the field of contrast agents and especially relates to an ultrasonic/magnetic resonance bimodal contrast agent and its preparation method and use. A nanoparticle suspension with a magnetic resonance imaging function as a raw material is processed to form hollow spherical nanoparticle aggregates by a spray drying technology so that the bimodal contrast agent with both ultrasonic and magnetic resonance imaging functions is constructed. The ultrasonic/magnetic resonance bimodal contrast agent has the advantages of ultrasonic and magnetic resonance imaging, realizes complementation of imaging sensitivity and image resolution and can acquire more information related to focus positions. The preparation method provides a novel method for fast, efficient and controllable preparation of the bimodal contrast agent.

Description

technical field [0001] The invention relates to the preparation of a contrast agent, in particular to an ultrasound / magnetic resonance dual-mode contrast agent, its preparation method and application. Background technique [0002] The early detection of many major diseases (especially cancer) largely relies on the development of medical imaging technology, which provides a powerful means for clinicians to obtain anatomical and physiological information, and it has also changed from relying solely on morphological changes for diagnosis. It has gradually developed into a comprehensive diagnosis and treatment system integrating form, function and treatment. However, various medical imaging techniques have their own advantages and disadvantages in terms of spatial and temporal resolution, and so far no imaging method can obtain complete biological information. [0003] Among the many medical imaging technologies, ultrasonic diagnosis has become the most commonly used imaging me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/06A61K49/22
CPCA61K49/0002A61K49/183A61K49/223
Inventor 邢占文陈瑶刘卫卫
Owner SUZHOU UNIV
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