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Crocetin salt injection and preparation process thereof

The invention relates to a technology of crocus acid salt and preparation process, which is applied in the field of pharmaceutical preparations, can solve problems such as low solubility of crocus acid, and achieve the effects of improving bioavailability, rapid onset of action, and stable and reliable action.

Inactive Publication Date: 2015-03-25
WEIHAI NOVODA PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a crocetin injection and a preparation process thereof. The injection has the advantages of high bioavailability, convenient use, safety and reliability, and is suitable for clinical treatment; the preparation process is simple, economical, and suitable for industrial production. High social and economic benefits, solve the problem of low solubility of crocetin in water

Method used

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  • Crocetin salt injection and preparation process thereof
  • Crocetin salt injection and preparation process thereof
  • Crocetin salt injection and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] In this example, 100 g of gardenia fruit was used to grind, and 800 g of 75% ethanol was used as a solvent for ultrasonic extraction for 1 hour, filtered, and 600 g of 75% ethanol was added to the filter residue for ultrasonic extraction for 1 hour, and the filtrates were combined and concentrated under reduced pressure to a relative density of 1.15. Add 400g of 80% ethanol to refrigerate for 10h, filter the precipitate, concentrate the supernatant under reduced pressure to a relative density of 1.15, add 800g of 80% ethanol and refrigerate for 10h, dissolve the precipitate in water, inject D101 and AB-8 series large Porous resin column, washed with 15% ethanol until nearly colorless, eluted with 85% ethanol, collected eluate, dried under reduced pressure to obtain Gardenia jasmine extract, set aside.

[0032] Dissolve the gardenia extract in water, dry it at 50°C and grind it into powder to obtain refined gardenia extract, dissolve it in 95% ethanol, mix the sample with...

Embodiment 2

[0036] In this example, 100 g of gardenia fruit is used to crush, and 800 g of 75% ethanol is used as a solvent for ultrasonic extraction for 1 hour, filtered, and the filter residue is added with 600 g of 75% ethanol as a solvent for ultrasonic extraction for 1 hour, the filtrates are combined, concentrated under reduced pressure to a relative density of 1.20, and the concentrated solution Add 400g of 80% ethanol to refrigerate for 10h, filter the precipitate, concentrate the supernatant under reduced pressure to a relative density of 1.20, add 800g of 80% ethanol to refrigerate for 10h, dissolve the precipitate in water, inject D101 and AB-8 series large Porous resin column, washed with 15% ethanol until nearly colorless, eluted with 85% ethanol, collected eluate, dried under reduced pressure to obtain Gardenia jasmine extract, set aside.

[0037] Dissolve the gardenia extract in water, dry it at 50°C and grind it into powder to obtain refined gardenia extract, dissolve it in...

Embodiment 3

[0041] Adopt high-sugar and high-fat diet to raise SD rats, cause hyperlipidemia model, observe the influence of the obtained product crocetin of the present invention on blood fat of rats.

[0042] Effect of crocetin on blood lipid content in rats ( ,n=8)

[0043]

[0044] Note: Compared with the normal control group, 1） P2） P3） P<0.01.

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PUM

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Abstract

The invention relates to crocetin salt and an injection preparation thereof. The crocetin salt has good water solubility, can directly enter into blood, quickly acts and is stable and reliable. The injection of the crocetin salt can be prepared by dissolving the crocetin salt and sodium chloride into injection water. The injection is capable of improving the bioavailability of the crocetin salt and quickly taking treatment effect, and has stable quality.

Description

technical field [0001] The invention relates to crocetin injection and belongs to the field of pharmaceutical preparations. Background technique [0002] Cardiovascular and cerebrovascular diseases are characterized by high mortality, high recurrence rate, and high disability rate. As our country gradually enters an aging society, cardiovascular and cerebrovascular diseases have an increasing impact on our people, seriously threatening the lives of patients. If timely and effective treatment is not obtained, it is easy to cause death. At present, the treatment of cardiovascular and cerebrovascular diseases is mainly based on chemically synthesized drugs and biological products, which cause great damage to the liver, and the therapeutic effect is not ideal. [0003] Crocetin can improve oxygen diffusion and consumption in plasma, and is used to treat hypertension, coronary heart disease, hyperlipidemia, etc. It also has significant choleretic and cholesterol-lowering effects...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/557A61P9/12A61P3/06A61P9/10A61P9/00
Inventor 王河东李磊
Owner WEIHAI NOVODA PHARMA GRP
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