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TPE material for medical infusion device tube and preparation method thereof

An infusion set and hose technology, applied in the field of TPE materials and their preparation, can solve problems such as unsuitable medical materials, toxic and side effects, and achieve the effects of good anti-oxidation performance, good biocompatibility, and ensuring treatment safety.

Inactive Publication Date: 2015-03-25
SHANGHAI KANGDELAI ENTERPRISE DEV GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Studies have shown that DEHP used for plasticizing vinyl chloride resin has toxic and side effects on various organs of humans and animals. What is even more worrying is that the hydrolysis of DEHP will produce monoethylhexyl phthalate (MEHP), which has far more toxic and side effects. Much higher than DEHP
In 2001, DEHP plasticized polyvinyl chloride was listed as a carcinogenic substance by the International Cancer Research Center and should not be used as a medical material

Method used

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  • TPE material for medical infusion device tube and preparation method thereof
  • TPE material for medical infusion device tube and preparation method thereof
  • TPE material for medical infusion device tube and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0019] Take the raw material of following weight ratio: the SEBS of 100 weight parts, the copolymerized polypropylene of 30 weight parts, the oleic acid amide of 20 weight parts, the antioxidant of 1 weight part (antioxidant 1010 and 168 are each 0.5 weight part ); Add SEBS and copolymerized polypropylene into the high-speed mixer and mix for 2 to 3 minutes; adjust the speed of the stirring blade in the high-speed mixer to 1500 rpm, and start heating to 82°C, then put oleic acid amide and anti Slowly add the oxygen agent, and then mix for 5 minutes before discharging; put the mixed raw materials into the twin-screw machine for extrusion and granulation. , The temperature of the compression section is 170°C~180°C, the temperature of the metering section is 180°C~190°C, the temperature of the neck is 190°C~200°C, and the temperature of the die is 190°C~200°C. The TPE material used for the hose of the medical infusion set of the present invention can be obtained.

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Abstract

The invention discloses a TPE material for medical infusion device tube and a preparation method thereof. The TPE materials includes the following raw materials by weight: 100 portions of SEBS, 30 portions of co-polypropylene, 20 portions of oleamide and 1 portion of an antioxidant. The medical infusion device tube prepared from the TPE material has no adsorption effect on many drugs, so that drug dosage accuracy and the therapeutic effect are guaranteed; and the problem of participation of released paclitaxel injection and the polyoxyethylene castor oil in plasticizing agent in the reaction are avoided, so as to ensure the use effect of anti-cancer drug such as paclitaxel. In addition, the medical infusion device tube can avoid the problem of migration of processing aid or plasticizer into the blood or in medical liquid, and the important indexes including pH value variation, reducing substances, heavy metal content, cell toxicity, UV absorbance, sensitization response and hemolytic reaction are superior to those of the similar polyvinyl chloride products, so as to ensure the safety of patients.

Description

technical field [0001] The invention relates to a TPE material used for medical infusion set hose and a preparation method thereof. Background technique [0002] PVC (polyvinyl chloride) is generally used as the material of traditional medical infusion set hoses. However, domestic and foreign usage and research data show that polyvinyl chloride resin and its additive DEHP are harmful to human health and the environment. [0003] In 1987, vinyl chloride was identified as a human carcinogen by the International Agency for Research on Cancer. No matter when polyvinyl chloride resin is synthesized or processed, more or less vinyl chloride will always be produced. Studies have found that long-term exposure to vinyl chloride monomer can cause symptoms such as neurasthenia, chloracne, and Raynaud's disease, collectively referred to as vinyl chloride disease. [0004] Studies have shown that DEHP used for plasticizing vinyl chloride resin has toxic and side effects on various orga...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L53/02C08L23/14C08K5/20
Inventor 李云豹刘华龙周紫英
Owner SHANGHAI KANGDELAI ENTERPRISE DEV GRP CO LTD
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