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Functionalized graphene oxide loaded nano-silver antibacterial material and its preparation method and application

A nano-silver antibacterial and graphene technology, applied in the field of sterilization, antibacterial, aminated polyethylene glycol functionalized graphene oxide-loaded nano-silver antibacterial materials and its preparation field, can solve the problem that no nano-silver antibacterial has been found Material antibacterial, sterilizing and other issues, to achieve good water solubility and stability, improve stability, improve the effect of loading efficiency

Active Publication Date: 2017-07-04
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, no reports have been found about nano-silver antibacterial materials loaded with aminated polyethylene glycol-functionalized graphene oxide with different particle sizes and their use in antibacterial and bactericidal applications.

Method used

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  • Functionalized graphene oxide loaded nano-silver antibacterial material and its preparation method and application
  • Functionalized graphene oxide loaded nano-silver antibacterial material and its preparation method and application
  • Functionalized graphene oxide loaded nano-silver antibacterial material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044]Example 1: Preparation of aminated polyethylene glycol functionalized graphene oxide loaded nano-silver antibacterial material

[0045] (1) The preparation of graphene oxide adopts the conventional Hummers method, and the specific steps are as follows: Weigh 1g of graphite powder and place it in a round bottom flask, then add 6g of potassium permanganate and mix well, then add 131mL of concentrated sulfuric acid and concentrated phosphoric acid mixed acid (volume ratio 9:1). First heat the above reactant to 35-40°C and stir evenly, then heat to 50°C and stir for 12h. After the reaction was completed, the reactant was cooled to room temperature and poured into 100 mL of ice water, and 3 mL of 30% H 2 o 2 . The mixture was passed through a metal standard test sieve (W.S.Tyler, 300 μm), then the filtrate was centrifuged at 6000 rpm for 1 h, the supernatant was discarded, and the lower layer of solid matter was successively washed with 200 mL of water, 200 mL of 30% HCl a...

Embodiment 2

[0048] Example 2: Preparation of aminated polyethylene glycol functionalized graphene oxide loaded nano-silver antibacterial material

[0049] (1) the preparation of graphene oxide is the same as embodiment 1

[0050] (2) The preparation of aminated polyethylene glycol-modified graphene oxide (GO@PEG) is the same as in Example 1.

[0051] (3) Prepare a 1 mg / mL solution of GO@PEG prepared above with distilled water, take 10 mL and add 10 mg of silver nitrate powder, after the silver nitrate is dissolved, heat the solution to boiling, add 15 mg of sodium citrate powder, and further After boiling and refluxing for 1 hour, cooling to room temperature, the aminated polyethylene glycol functionalized graphene oxide-loaded nano-silver antibacterial material can be prepared, wherein the particle size of the loaded nano-silver is about 30 nm.

Embodiment 3

[0052] Example 3: Preparation of aminated polyethylene glycol functionalized graphene oxide loaded nano-silver antibacterial material

[0053] (1) the preparation of graphene oxide is the same as embodiment 1

[0054] (2) The preparation of aminated polyethylene glycol-modified graphene oxide (GO@PEG) is the same as in Example 1.

[0055] (3) Prepare a 1 mg / mL solution of GO@PEG prepared above with distilled water, take 10 mL and add 10 mg of silver nitrate powder, after the silver nitrate is dissolved, heat the solution to boiling, add 10 mg of sodium citrate powder, and further Boiling reflux 1h. After cooling down to room temperature, the aminated polyethylene glycol functionalized graphene oxide loaded nano-silver antibacterial material can be prepared, wherein the particle size of the loaded nano-silver is about 50 nm.

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Abstract

The invention belongs to the technical field of nano-silver antibacterial materials and discloses an aminated polyethylene glycol functional graphene oxide loaded nano-silver antibacterial material, a preparation method of the antibacterial material and an application of the antibacterial material in the fields of bacteriostasis and sterilization. The method comprises the following steps: adding aminated polyethylene glycol into an aqueous solution of graphene oxide, adding 1-ethyl-(3-dimethylaminopropyl) carbonyldiimine hydrochloride and N-hydroxy succinimide, regulating the pH value, stirring, and reacting, thereby obtaining the aminated polyethylene glycol modified graphene oxide; preparing the aqueous solution of the graphene oxide, adding silver nitrate, heating until the solution is boiled after dissolving, adding sodium citrate or NaBH4 aqueous solution, reacting, and cooling, thereby obtaining the aminated polyethylene glycol functional graphene oxide loaded nano-silver antibacterial material. The antibacterial material prepared by the invention has good water solubility and stability, the loading efficiency and antibacterial activity are obviously improved, and the antibacterial material has obvious antibacterial activity and can be widely applied to the fields of bacteriostasis and sterilization.

Description

technical field [0001] The invention belongs to the technical field of nano-silver antibacterial materials, and in particular relates to an aminated polyethylene glycol functionalized graphene oxide-loaded nano-silver antibacterial material, a preparation method thereof, and applications in fields such as antibacterial and bactericidal. Background technique [0002] Health is one of the topics that people are most concerned about. However, bacteria are everywhere and pervasive, and their spread and spread seriously threaten human health. Using antibacterial materials to kill and inhibit the growth and reproduction of harmful bacteria is an important means to improve human health. [0003] In response to the resistance of bacteria to antibiotics, it is an important strategy in the field of medicine to develop more efficient antibacterial drugs, especially drugs that inhibit drug-resistant bacteria. Among many antibacterial materials, inorganic antibacterial agents have the a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N59/16A01N25/08A01P1/00
Inventor 刘杰陈旭黄小全周贤波
Owner JINAN UNIVERSITY
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