A kind of bamboo leaf flavonoid complex liposome, preparation method and application thereof

A technology of bamboo leaf flavonoids and compound lipids is applied in the directions of pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., which can solve the problems of limited efficacy expression, wide application, difficult skin absorption, low bioavailability, etc., and achieves enhancement and extension. The effect of beauty repair, product quality stability, skin nutrition metabolism repair

Active Publication Date: 2017-12-22
烟台新时代健康产业日化有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, in the application of bamboo leaf flavonoids in the field of skin care, most of them are directly added and used. Factors such as light, heat, oxygen in the environment, metal ions and pH value in the system seriously affect its stability.
At the same time, bamboo leaf flavonoids also have problems such as easy oxidation, low water solubility, difficult skin absorption and low bioavailability, which limit the wide application of its efficacy expression and formulation development.

Method used

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  • A kind of bamboo leaf flavonoid complex liposome, preparation method and application thereof
  • A kind of bamboo leaf flavonoid complex liposome, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1) Weigh 0.1g bamboo leaf flavonoids (of which the mass fraction of total flavonoids is 24%), 0.2g egg yolk lecithin, 0.02g stigmasterol, 0.01g vitamin C, mix well, dissolve in 100g absolute ethanol, and water bath at 40℃ Stir fully until it is completely dissolved, and keep it for 10 minutes to obtain mixed solution I;

[0040] 2) Weigh 0.1g potassium hyaluronate and 0.1g polyethylene glycol 4000, mix them evenly, dissolve them in 80g deionized water, stir well until completely dissolved, stir and heat up to 40°C, keep for 10min to obtain mixed solution II;

[0041] 3) Slowly inject the mixed solution I obtained in step 1) into the mixed solution II obtained in step 2), stir and mix evenly to obtain a composite liposome suspension solution, vacuum to -0.06MPa, stir at 40°C, and remove Stir the ethanol in the solution to make the initial emulsion;

[0042] 4) Transfer the primary emulsion prepared in step 3) to a high-pressure homogenizer, and perform a homogenization cycle t...

Embodiment 2

[0044] 1) Weigh 2.0g bamboo leaf flavonoids (of which 40% total flavonoids mass fraction), 2.0g egg yolk lecithin, 3.0g hydrogenated lecithin, 0.5g stigmasterol, 0.1g superoxide dismutase, mix well, and dissolve in 100g of anhydrous ethanol, fully stirred in a water bath at 45°C until completely dissolved, kept for 10 minutes, mixed solution I;

[0045] 2) Weigh 2.0g sodium hyaluronate, 1.0g polyethylene glycol 4000, 1.0g Tween 80, mix well, dissolve in 120g deionized water, stir well until completely dissolved, stir and heat up to 45℃, keep for 10min, Obtain a mixed solution II;

[0046] 3) Slowly inject the mixed solution I obtained in step 1) into the mixed solution II obtained in step 2), stir and mix evenly to obtain a composite liposome suspension solution, vacuum to -0.06MPa, stir at 45°C, and remove the solution Stir the ethanol in the medium to make the initial emulsion;

[0047] 4) Transfer the primary emulsion prepared in step 3) to a high-pressure homogenizer, and condu...

Embodiment 3

[0049] 1) Weigh 1.0g bamboo leaf flavonoids (including 65% total flavonoids mass fraction), 2.0g soybean lecithin, 0.2g cholesterol, 0.01g vitamin E, mix well, dissolve in 100g absolute ethanol, 42℃ water bath conditions Stir to completely dissolve, keep it for 10 minutes to obtain mixed solution I;

[0050] 2) Weigh 1.0g hyaluronic acid and 2.0g Tween 80, mix them evenly, dissolve them in 100g deionized water, stir well to dissolve completely, stir and heat to 42°C, keep for 10min to obtain mixed solution II;

[0051] 3) Slowly inject the mixed solution I obtained in step 1) into the mixed solution II obtained in step 2, stir and mix uniformly to obtain a composite liposome suspension solution, vacuum to -0.06MPa, stir at 42°C, and remove the solution Ethanol, stir evenly to make the initial emulsion;

[0052] 4) Transfer the primary emulsion prepared in step 3) to a high-pressure homogenizer, and conduct a homogenizing cycle treatment under a pressure of 100MPa. When the emulsion ...

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Abstract

The invention relates to a composite liposome of bamboo leaf flavonoids, a preparation method and an application thereof. The bamboo leaf flavone composite liposome of the present invention contains the following components in weight ratio, bamboo leaf flavone: compound agent: membrane material: proppant: antioxidant: solubilizer=0.1-2: 0.1-2: 0.2 ‑5: 0.02‑0.5: 0.01‑0.1: 0.1‑2. The invention protects the stability and integrity of its functional components by effectively coating the bamboo leaf flavonoids. In the wrapping process, hyaluronic acid with excellent moisturizing effect is compounded to prepare bamboo leaf flavonoid complex liposome, which improves its system compatibility in the development of skin care products. At the same time, the unique carrying performance and slow-release ability of liposomes can promote the absorption and long-term care of bamboo leaf flavonoid complex liposomes in the skin, and improve the expression of skin moisturizing, sun protection, whitening and anti-aging effects.

Description

Technical field [0001] The invention relates to the field of cosmetics, in particular to a bamboo leaf flavone composite liposome, a preparation method and an application thereof. Background technique [0002] Bamboo has a profound and unique cultural connotation in our country, and also has a relatively long history of edible and medicinal use. In 1998, the Ministry of Health officially promulgated the bamboo leaves as natural resources with the same source of medicine and food. With the development of modern science, people have gradually deepened the research on bamboo leaves. The flavonoids, phenolic acids, alkaloids, lactones, terpenoids, polysaccharides and amino acids rich in bamboo leaves are the beneficial active ingredients needed by the human body. Bamboo leaf flavonoids are newly developed plant flavonoid preparations with an average content of more than 2%, mainly flavonoid glycosides, which have excellent biological effects such as anti-free radicals, anti-oxidatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9794A61K8/73A61K8/14A61Q19/00A61Q17/04A61Q19/02A61Q19/08
Inventor 毕利顺邹鹏飞魏星杨建召唐文金卢伟超
Owner 烟台新时代健康产业日化有限公司
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